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141por Abdul-Hay, Samer O, Sahara, Tomoko, McBride, Melinda, Kang, Dongcheul, Leissring, Malcolm A“…BACKGROUND: Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. …”
Publicado 2012
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142por Ma, Sanyuan, Wang, Xiaogang, Liu, Yuanyuan, Gao, Jie, Zhang, Shengling, Shi, Run, Chang, Jiasong, Zhao, Ping, Xia, Qingyou“…Furthermore, it is the first time to show that co-introduction of TALEN and ssODN generated unwanted complex structure variation. …”
Publicado 2014
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144“…In this paper, we have attempted optimization of production of enzyme carboxymethylcellulase or endoglucanase from the bacterium Bacillus amyloliquefaciens SS35. Optimization has been carried out in two stages using statistical experimental design, viz. medium optimization and optimization of fermentation parameters. …”
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145“…Interestingly, RPA in the complex adopts a horse shoe-like shape resembling its conformation in the presence of long ssDNA (>30 nucleotides). Furthermore, the recruitment of the Tim-Tipin-RPA complex to ssDNA is modulated by the RPA conformation and requires RPA to be in the more compact 30 nt ssDNA binding mode. …”
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146por Du, Jingchun, Hong, Jianming, Xu, Chun, Cai, Yuanyuan, Xiang, Bo, Zhou, Chengbo, Xu, Xia“…Then, thirty ssDNA aptamers were sequenced, in which two ssDNA aptamers with identical DNA sequence were confirmed, based on the alignment results, and designated as A10-2. …”
Publicado 2015
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147“…[Image: see text] We investigate by means of molecular dynamics simulations stretch-induced stepwise translocation of single-stranded DNA (ssDNA) through graphene nanopores. The intrinsic stepwise DNA motion, found to be largely independent of size and shape of the graphene nanopore, is brought about through alternating conformational changes between spontaneous adhesion of DNA bases to the rim of the graphene nanopore and unbinding due to mechanical force or electric field. …”
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149“…Replication protein A (RPA) is the main ssDNA-binding protein complex involved in DNA metabolism. …”
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151por Patel, Nikesh, Wroblewski, Emma, Leonov, German, Phillips, Simon E. V., Tuma, Roman, Twarock, Reidun, Stockley, Peter G.Enlace del recurso
Publicado 2017
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152por Alshaer, Walhan, Ababneh, Nida, Hatmal, Mamon, Izmirli, Heba, Choukeife, Moujab, Shraim, Alaa, Sharar, Nour, Abu-Shiekah, Aya, Odeh, Fadwa, Al Bawab, Abeer, Awidi, Abdalla, Ismail, Said“…In this study, we have developed a ssDNA aptamer with high affinity and selectivity of targeting the EpCAM protein extracellular domain. …”
Publicado 2017
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153por Guarneri, Claudio, Wollina, Uwe, Lotti, Torello, Maximov, Georgi Konstantinov, Lozev, Ilia, Gianfaldoni, Serena, Pidakev, Ivan, Lotti, Jacopo, Tchernev, Georgi“…Herein we describe a case of a lady who had a refractory form of SS, resulted in a paraneoplastic cutaneous disease, and AML. …”
Publicado 2018
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154por Regal, Jean F., Laule, Connor F., McCutcheon, Luke, Root, Kate M., Lund, Hayley, Hashmat, Shireen, Mattson, David L.“…In the Dahl Salt‐Sensitive (SS) rat model, lymphocytes play a role in development of hypertension and kidney damage after increased sodium intake. …”
Publicado 2018
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157por Rangel, Luiz Thiberio, Marden, Jeremiah, Colston, Sophie, Setubal, João Carlos, Graf, Joerg, Gogarten, Johann Peter“…However, a factor that is commonly associated with virulent Gram-negative bacteria, including many Aeromonas spp., is the type 3 secretion system (T3SS), which is used to inject effector proteins into target eukaryotic cells. …”
Publicado 2019
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158“…CONCLUSION: PaSS is an effective sequence simulator for PacBio sequencing. …”
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159por Klec, Christiane, Ziomek, Gabriela, Pichler, Martin, Malli, Roland, Graier, Wolfgang F.Enlace del recurso
Publicado 2019
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160por Zhao, Yan, Li, Gang, Yao, Xin-Yue, Lu, Shu-Guang, Wang, Jing, Shen, Xiao-Dong, Li, Ming“…Genetic analysis revealed the presence of a chromosomal pathogenicity island (PAI) designated SsPI-1 in Chinese epidemic S. suis strains. The purpose of this study is to define the role of SsPI-1 in the virulence of S. suis. (2) Methods: A SsPI-1 deletion mutant was compared to the wild-type strain regarding the ability to attach to epithelial cells, to cause host disease and mortality, and to stimulate host immune response in experimental infection of piglets. (3) Results: Deletion of SsPI-1 significantly reduces adherence of S. suis to epithelial cells and abolishes the lethality of the wild-type strain in piglets. …”
Publicado 2019
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