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“…[Image: see text] A water-compatible and recyclable catalyst for nuclear magnetic resonance (NMR) hyperpolarization via signal amplification by reversible exchange (SABRE) was developed. The [Ir(COD)(IMes)Cl] catalyst was attached to a polymeric resin of bis(2-pyridyl)amine (heterogeneous SABRE catalyst, HET-SABRE catalyst), and it amplified the (1)H NMR signal of pyridine up to (−) 4455-fold (43.2%) at 1.4 T in methanol and (−) 50-fold (0.5%) in water. …”
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“…PURPOSE: SABR is a treatment option for patients with lung tumors that employs fiducials to track tumors during the breathing cycle. …”
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“…The key components of SABR are described. The current evidence base for SABR for the treatment of primary and secondary lung tumours is appraised, and key ongoing trials are identified.…”
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“…From the data shown, the VMAT approach should be considered adequately robust for single fraction SABR.…”
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“…Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclear spin polarization, respectively. This method, dubbed “SABRE in shield enables alignment transfer to heteronuclei” or “SABRE-SHEATH”, promises to be a simple, cost-effective way to hyperpolarize heteronuclei. …”
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“…Linear scleroderma “en coup de sabre” is a subset of localized scleroderma with band-like sclerotic lesions typically involving the fronto-parietal regions of the scalp. …”
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“…Eschewing microplate-based compound collections for one-bead-one-compound (OBOC) combinatorial libraries, we have developed hνSABR (Light-Induced and -Graduated High-Throughput Screening After Bead Release), a microfluidic architecture that integrates a suspension hopper for compound library bead introduction, droplet generation, microfabricated waveguides to deliver UV light to the droplet flow for photochemical compound dosing, incubation, and laser-induced fluorescence for assay readout. …”
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“…The scleroderma en coup de sabre is a variant of localized scleroderma that occurs preferentially in children. …”
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“…In this work we describe how the signal enhancements obtained through the SABRE process in methanol-d (4) solution are significantly affected by pH. …”
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“…[Image: see text] The conversion of [IrCl(COD)(IMes)] (COD = cis,cis-1,5-cyclooctadiene, IMes = 1,3-bis(2,4,6-trimethyl-phenyl)imidazole-2-ylidene) in the presence of an excess of para-hydrogen (p-H(2)) and a substrate (4-aminopyridine (4-AP) or 4-methylpyridine (4-MP)) into [Ir(H)(2)(IMes)(substrate)(3)]Cl is monitored by (1)H NMR spectroscopy using a benchtop (1 T) spectrometer in conjunction with the p-H(2)-based hyperpolarization technique signal amplification by reversible exchange (SABRE). A series of single-shot (1)H NMR measurements are used to monitor the chemical changes that take place in solution through the lifetime of the hyperpolarized response. …”
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“…Four‐dimensional computerized tomography (4DCT) is required for stereotactic ablative body radiotherapy (SABR) of mobile targets to account for tumor motion during treatment planning and delivery. …”
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“…RESULTS: Eighty-seven men received SABR to 115 metastases. Nineteen patients were castrate-resistant and 68 hormone-sensitive at the time of SABR. …”
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“…Our results also suggest that DCE-MRI one-week post-SABR may be too early for response assessment, at least for single fraction SABR, whereas 2.5 weeks appears sufficiently long to minimize confounding acute effects.…”
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“…A total of 30 patients who underwent SABR for lung cancer were selected retrospectively. …”
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“…This study quantified the interplay and gradient effects on GTV dose coverage for 3D CRT, dMLC IMRT, and VMAT SABR treatments for target amplitudes of 5–30 mm using 3DVH v3.1 software incorporating 4D Respiratory MotionSim (4D RMS) module. …”
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“…Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. …”
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