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  1. 721
    “…In this study, we examine the characteristics of the endosymbiont-derived β-barrel insertase Sam50(1) in the excavate super-group. A candidate is further characterized in Trichomonas vaginalis, an unusual eukaryote possessing degenerate hydrogen-producing mitochondria called hydrogenosomes. …”
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    Analysis of the Sam50 translocase of Excavate organisms supports evolution of divergent organelles from a common endosymbiotic event
  2. 722
    por Pohl, Anna, Weiss, Ingrid M
    Publicado 2014
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    Real-time monitoring of calcium carbonate and cationic peptide deposition on carboxylate-SAM using a microfluidic SAW biosensor
  3. 723
    “…BACKGROUND: The nuclear protein Src-associated protein of 68 kDa in mitosis (Sam68) is known to bind RNA and be involved in cellular processes triggered in response to environmental stresses, including virus infection. …”
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    Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections
  4. 724
    “…Knockdown of Sam68 sensitizes human colon cancer cells to genotoxic stress-induced apoptosis and genetic deletion of Sam68 dampens colon tumor burden in mice. …”
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    Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation
  5. 725
    “…Among these post-translational modifications, C-methylations have been proposed to be catalyzed by two putative radical S-adenosylmethionine (rSAM) enzymes, PoyB and PoyC. Here we report the in vitro activity of PoyC, the first B(12)-dependent rSAM enzyme catalyzing peptide C(β)-methylation. …”
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    The B(12)-Radical SAM Enzyme PoyC Catalyzes Valine C(β)-Methylation during Polytheonamide Biosynthesis
  6. 726
    “…Furthermore, in vitro studies, using recombinant protein, show that TPMT p.Y240S is less stable than both TPMTwt and TPMT p.Y240C. The addition of SAM increases the stability and, in agreement with Isothermal Titration Calorimetry (ITC) data, higher molar excess of SAM is needed in order to stabilize TPMT p.Y240C and TPMT p.Y240S compared to TPMTwt. …”
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    One amino acid makes a difference–Characterization of a new TPMT allele and the influence of SAM on TPMT stability
  7. 727
    “…Radical S-adenosylmethionine (rSAM) enzymes use a 5’-deoxyadensyl 5’-radical to methylate a wide array of diverse substrates including proteins, lipids and nucleic acids. …”
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    Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii
  8. 728
    “…METHODS: The South Australian mCRC Registry (SAmCRC) was analyzed to assess the number of patients presenting with brain metastasis during their lifetime. …”
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    Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry
  9. 729
    “…We found that SAM treatment caused a significant dose-dependent decrease in cell proliferation, invasion, migration, anchorage-independent growth and increased apoptosis in vitro. …”
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    Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications
  10. 730
    “…AhbD belongs to the family of Radical SAM enzymes and contains two [4Fe–4S] clusters. …”
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    The auxiliary [4Fe–4S] cluster of the Radical SAM heme synthase from Methanosarcina barkeri is involved in electron transfer
  11. 731
    “…INTRODUCTION: Mortality among children hospitalised for complicated severe acute malnutrition (SAM) remains high despite the implementation of WHO guidelines, particularly in settings of high HIV prevalence. …”
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    Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study
  12. 732
    “…INTERPRETATION: This study identifies TGF-β1/p65/MAT2A pathway that is involved in the regulation of intracellular SAM concentration and liver fibrogenesis, suggesting that this pathway is a potential therapeutic target for hepatic fibrosis. …”
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    TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
  13. 733
    “…Here, we report that the RBP Sam68 promotes the localization and translation of Arc mRNA preferentially in distal dendrites of rodent hippocampal CA1 pyramidal neurons. …”
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    Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons
  14. 734
    “…SAM-I, SAM-I/IV, and SAM-IV are the three most commonly found SAM riboswitches, but the structure of SAM-IV is still unknown. …”
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    Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution
  15. 735
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    Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
  16. 736
    “…S‐Adenosyl‐L‐methionine (AdoMet) analogs in combination with methyltransferases (MTases) have proven useful to map or block and release MTase target sites, however their enzymatic generation has been limited to aliphatic groups at the sulfur atom. We engineered a SAM synthetase from Cryptosporidium hominis (PC‐ChMAT) for efficient generation of AdoMet analogs with photocaging groups that are not accepted by any WT MAT reported to date. …”
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    Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions
  17. 737
    “…In this work, we designed potential SARS-CoV-2 MTase Nsp14 and Nsp16 inhibitors by using bioisosteric substitution of the sulfonium and amino acid substructures of the cosubstrate S-adenosylmethionine (SAM), which serves as the methyl donor in the enzymatic reaction. …”
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    Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate
  18. 738
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    Retraction Note to: High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer
  19. 739
    “…The aim of this study was to determine GoodSAM’s effect on survival to hospital discharge following out-of-hospital cardiac arrest. …”
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    The effect of the GoodSAM volunteer first-responder app on survival to hospital discharge following out-of-hospital cardiac arrest
  20. 740
    “…SAM-TB is a useful tool for guiding both treatment and epidemiological investigation.…”
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    SAM-TB: a whole genome sequencing data analysis website for detection of Mycobacterium tuberculosis drug resistance and transmission
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