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  1. 681
    “…This study was conducted to investigate the optimal threshold for clustering 16S ribosomal RNA gene sequences into operational taxonomic units (OTUs) by comparing the results of NGS technology with those of the Sanger method, which has a higher accuracy of sequence per single read than NGS technology. …”
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    Refinement of microbiota analysis of specimens from patients with respiratory infections using next-generation sequencing
  2. 682
    “…However, many studies were restricted to a few sequences generated by clone libraries and Sanger sequencing, which may have underestimated the diversity of As(III)-oxidizers in natural environments. …”
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    New Arsenite Oxidase Gene (aioA) PCR Primers for Assessing Arsenite-Oxidizer Diversity in the Environment Using High-Throughput Sequencing
  3. 683
    “…It is a sensitive and fast method for the detection of somatic mosaicism. Compared to Sanger sequencing, which represents a cumulative signal, NGS technology analyzes the sequence of each DNA read in a sample. …”
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    Detection of Mosaic Variants in Mothers of MPS II Patients by Next Generation Sequencing
  4. 684
    “…RESULTS: The allelic balance of parental‐pool variants was around 8.97%. Sanger sequencing uncovered false positives in 1.5% of sporadic variants. …”
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    Interest of exome sequencing trio‐like strategy based on pooled parental DNA for diagnosis and translational research in rare diseases
  5. 685
    “…In six of these cases, there was no evidence of mosaicism on Sanger sequencing—the variant was not detected on Sanger sequencing in three cases, and it appeared to be heterozygous in three others. …”
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    Somatic mosaicism detected by genome-wide sequencing in 500 parent–child trios with suspected genetic disease: clinical and genetic counseling implications
  6. 686
    “…A novel alternative splicing variant detected by whole-exome sequencing was validated by Sanger sequencing. The functional effect of the mutation was predicted with Mutation Tasting. …”
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    A Novel Mutation in ATRX Causes Alpha-Thalassemia X-Linked Intellectual Disability Syndrome in a Han Chinese Family
  7. 687
    “…While 16S rRNA PCR-Sanger sequencing has paved the way for the diagnosis of culture-negative bacterial infections, it does not provide the composition of polymicrobial infections. …”
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    Improving the Diagnosis of Bacterial Infections: Evaluation of 16S rRNA Nanopore Metagenomics in Culture-Negative Samples
  8. 688
    “…BACKGROUND AND OBJECTIVE: Wilson disease (WD) is an autosomal recessive copper metabolic disorder caused by mutations in ATP7B. Sanger sequencing is currently used for ATP7B variant identification. …”
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    Laboratory and clinical evaluation of a microarray for the detection of ATP7B mutations in Wilson disease in China
  9. 689
    “…The first sequencing of a complete genome was published forty years ago by the double Nobel Prize in Chemistry winner Frederick Sanger. That corresponded to the small sized genome of a bacteriophage, but since then there have been many complex organisms whose DNA have been sequenced. …”
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    DNA Sequencing Sensors: An Overview
  10. 690
    “…Methods: We used in silico prediction tools, reverse transcription (RT)‐PCR, and Sanger sequencing on blood/bone marrow‐derived RNA specimens to determine the aberrant splicing. …”
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    Identification and interpretation of TET2 noncanonical splicing site intronic variants in myeloid neoplasm patients
  11. 691
    “…The Perl script is freely available from ftp://ftp.sanger.ac.uk/pub/pathogens/pools/. Contact: kh2@sanger.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.…”
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    Detecting SNPs and estimating allele frequencies in clonal bacterial populations by sequencing pooled DNA
  12. 692
    “…Availability and implementation: SnoopCGH is written in java and is available from http://snoopcgh.sourceforge.net/ Contact: jg10@sanger.ac.uk; tc5@sanger.ac.uk…”
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    SnoopCGH: software for visualizing comparative genomic hybridization data
  13. 693
    “…The database can be accessed at http://www.sanger.ac.uk/PostGenomics/S_pombe/microarray/. Copyright © 2006 John Wiley & Sons, Ltd.…”
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    Simplified primer design for PCR-based gene targeting and microarray primer database: two web tools for fission yeast
  14. 694
    “…This gives researchers the possibility of designing studies with adequate power to identify rare variants at a fraction of the economic and labor resources required by individual Sanger sequencing. As of today, few research groups working in plant sciences have exploited this potentiality, showing that pooled NGS provides results in excellent agreement with those obtained by individual Sanger sequencing. …”
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    The Quest for Rare Variants: Pooled Multiplexed Next Generation Sequencing in Plants
  15. 695
    “…Availability: Code is available as part of the Bioconductor package deepSNV. Contact: mg14@sanger.ac.uk; pc8@sanger.ac.uk…”
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    Subclonal variant calling with multiple samples and prior knowledge
  16. 696
    “…The results of these four assays showed 100% concordant results and had 100% accuracy as verified by Sanger sequencing. CONCLUSIONS: All of the referred methods can be used for genotyping ALDH2 rs671 with the same accuracy compared to Sanger sequencing. …”
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    Genotyping on ALDH2: Comparison of Four Different Technologies
  17. 697
    “…METHODS: We validated the Ion Torrent Personal Genome Machine (PGM) system using the Ion AmpliSeq Cancer Hotspot Panel and compared the results with those obtained using the gold standard methods, conventional PCR and Sanger sequencing. The cycleave PCR method was used to verify the results. …”
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    Validation of an Ion Torrent Sequencing Platform for the Detection of Gene Mutations in Biopsy Specimens from Patients with Non-Small-Cell Lung Cancer
  18. 698
    “…Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. …”
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    Mutation of MED12 is not a frequent occurrence in prostate cancer of Korean patients
  19. 699
    “…(Glu8Serfs*4), which was confirmed by Sanger sequencing and found to co-segregate with choroideremia. …”
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    Whole exome sequencing of a family revealed a novel variant in the CHM gene, c.22delG p.(Glu8Serfs*4), which co-segregated with choroideremia
  20. 700
    “…METHODS: Whole exome sequencing (WES) and Sanger sequencing was performed to study the variant leading to the disease. …”
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    Whole exome sequencing reveals a homozygous nonsense mutation in HEXA gene leading to Tay-Sachs disease in Saudi Family
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