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Mostrando 501 - 520 Resultados de 686 Para Buscar '"Sendai"', tiempo de consulta: 0.14s Limitar resultados
  1. 501
    “…Here, we extracted peripheral blood mononuclear cells (PBMCs) from a patient with sAD and induced them into iPSC by introducing the Sendai virus expressing Oct3/4, Sox2, c-Myc, and Klf4, which were subsequently induced into neural cells to build the cell model of AD. …”
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    Reconstruction of Alzheimer's Disease Cell Model In Vitro via Extracted Peripheral Blood Molecular Cells from a Sporadic Patient
  2. 502
    “…In this study, we found BFRF1 could down-regulate sendai virus-induced IFN-β promoter activity and mRNA expression of IFN-β and ISG54 during BFRF1 plasmid transfection and EBV lytic infection, but BFRF1 could not affect the promoter activity of NF-κB or IRF7. …”
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    Epstein-Barr Virus Early Protein BFRF1 Suppresses IFN-β Activity by Inhibiting the Activation of IRF3
  3. 503
    “…In this study, we found that cellular levels of O-GlcNAcylation decline in response to infection with Sendai virus. We identified a heavily O-GlcNAcylated serine-rich region between amino acids 249–257 of the mitochondrial antiviral signaling protein (MAVS); modification at this site disrupts MAVS aggregation and prevents MAVS-mediated activation and signaling. …”
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    O-Linked N-Acetylglucosamine Modification of Mitochondrial Antiviral Signaling Protein Regulates Antiviral Signaling by Modulating Its Activity
  4. 504
    “…Two clones were derived from female fibroblasts by using a retrovirus and the other two clones were derived from male peripheral blood mononuclear cells by using Sendai virus (episomal approach). The iPSC clones were transplanted into allogenic MHC-matched immune-competent cynomolgus macaques. …”
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    No Tumorigenicity of Allogeneic Induced Pluripotent Stem Cells in Major Histocompatibility Complex-matched Cynomolgus Macaques
  5. 505
    “…Thus, this study aimed to investigate the role of HO-1 in the differentiation of human induced pluripotent stem cells (hiPSCs) into hiPSC-derived cardiomyocytes (hiPSC-CMs). hiPSCs were generated from human fibroblasts and peripheral blood mononuclear cells using Sendai vectors and subjected to CRISPR/Cas9-mediated HMOX1 knock-out. …”
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    Role of Heme-Oxygenase-1 in Biology of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
  6. 506
    “…The Sendai Framework for Disaster Risk Reduction 2015–2030 placed human health at the centre of disaster risk reduction, calling for the global community to enhance local and national health emergency and disaster risk management (Health EDRM). …”
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    Health Workforce Development in Health Emergency and Disaster Risk Management: The Need for Evidence-Based Recommendations
  7. 507
    “…NSP5 proteins of both SARS-CoV and SARS-CoV-2 counteracted Sendai virus-induced IFN production. NSP5 variants G15S and K90R commonly seen in circulating strains of SARS-CoV-2 retained the IFN-antagonizing property. …”
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    SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3
  8. 508
    “…In this study, we conducted a screen of repurposed drugs using Sendai virus (an RNA virus of the family Paramyxoviridae), with human‐induced pluripotent stem cells (iPSCs) to explore existing drugs that may present anti‐RNA viral activity. …”
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    iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility
  9. 509
    “…USP18 upregulates the expression and production of type I interferon following infection with Sendai virus (SeV) or Encephalomyocarditis virus (EMCV). …”
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    USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
  10. 510
    “…MATERIALS AND METHODS: Four transgene‐free approaches for somatic reprogramming, including episome, minicircle, self‐replicative RNA, and sendai virus, were compared, from the perspective of cardiac progenitor marker expression, iCS formation, and cardiac differentiation. …”
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    Therapeutic effects of CXCR4(+) subpopulation of transgene‐free induced cardiosphere‐derived cells on experimental myocardial infarction
  11. 511
    “…Here we show that AT2s express high levels of MHCII independent of conventional inflammatory stimuli, and that selective loss of MHCII from AT2s in mice results in modest worsening of respiratory virus disease following influenza and Sendai virus infections. We also find that AT2s exhibit MHCII presentation capacity that is substantially limited compared to professional antigen presenting cells. …”
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    Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation
  12. 512
    “…Longitudinal measurements are possible by using reporter Sendai viruses, the murine counterpart of HPIV 1, that express luciferase, where the insertion location yields a wild-type (rSeV-luc(M-F*)) or attenuated (rSeV-luc(P-M)) phenotype. …”
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    Quantifying dose-, strain-, and tissue-specific kinetics of parainfluenza virus infection
  13. 513
    “…In this investigation, 293T cells were transfected with SARS-CoV-2 3CL and then infected with Sendai virus (SeV) to induce the RIG-I like receptor (RLR)-based immune pathway. q-PCR, luciferase reporter assays, and western blotting were used for experimental analyses. …”
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    SARS-CoV-2 3C-like protease antagonizes interferon-beta production by facilitating the degradation of IRF3
  14. 514
    “…Here, we designed stabilized recombinant versions of neuraminidase by replacing the N-terminal cytoplasmic domain, transmembrane, and extracellular stalk with tetramerization domains from the measles or Sendai virus phosphoprotein or from an Arabidopsis thaliana transcription factor. …”
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    A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model
  15. 515
    “…Sequence analysis and homology modeling predict that HPIV3 P possesses a long, disordered N-terminal tail (P(TAIL)) a coiled-coil multimerization domain (P(MD)), similar to the well-characterized paramyxovirus phosphoproteins from measles and Sendai viruses. Using a recombinantly expressed and purified construct of P(MD) and P(TAIL), we show that HPIV3 P in solution is primarily an alpha-helical tetramer that is stable up to 60 °C. …”
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    Human Parainfluenza Virus 3 Phosphoprotein Is a Tetramer and Shares Structural and Interaction Features with Ebola Phosphoprotein VP35
  16. 516
    “…Major global climate agreements, (i.e., the Sendai Framework for Disaster Risk Reduction, Paris Climate Agreement, and the Sustainable Development Goals) all emphasize the need to integrate disaster resilience and climate risks with continued sustainable development concerns. …”
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    Resilience Dividends and Resilience Windfalls: Narratives That Tie Disaster Resilience Co-Benefits to Long-Term Sustainability
  17. 517
    “…Consistently, A179L also suppressed apoptosis but enhanced the necroptosis induced by two RNA viruses, Sendai virus (SeV) and influenza virus (IAV). Our study uncovers a previously unrecognized role of A179L in regulating cell death and suggests that A179L re-directs its anti-apoptotic activity to necroptosis.…”
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    The A179L Gene of African Swine Fever Virus Suppresses Virus-Induced Apoptosis but Enhances Necroptosis
  18. 518
    “…This paper discusses the importance of risk communication as a critical component of early warning systems and explores the constant challenges that vulnerable communities face, how early warning systems sit within the wider Sendai Framework, and what governments have learned from the COVID-19 pandemic, and discusses how we can communicate more effectively in the future to reduce harm.…”
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    Should I stay or should I go now? Why risk communication is the critical component in disaster risk reduction
  19. 519
    “…Importantly, domain I of nsp4 inhibited Sendai virus-induced interferon β production, and this inhibitory effect was eliminated by Lovastatin, an HMGCR inhibitor, indicating that the upregulation of cellular cholesterol by nsp4 is a strategy used by PRRSV to suppress the antiviral innate immunity of its host. …”
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    Porcine reproductive and respiratory syndrome virus nsp4 positively regulates cellular cholesterol to inhibit type I interferon production
  20. 520
    por Khan, Shabana, Mishra, Jyoti
    Publicado 2022
    “…Accordingly, it highlights some important gaps in the risk communication across international agreements including Sendai Framework for Disaster Risk Reduction (SFDRR), Sustainable Development Goals (SDGs), and United Nations Framework Convention on Climate Change (UNFCCC), and evaluates their impacts at the local level. …”
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    Critical gaps and implications of risk communication in the global agreements—SFDRR, SDGs, and UNFCCC: 3 select case studies from urban areas of tropics in South Asia
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