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1041“…However, examination of EDTA blood sample revealed atypical lymphocytes and an isolated thrombocytopenia together with typical patterns of WBC and PLT histograms: a serrated curve of the platelet histogram and a peculiar peak on the left side of the WBC histogram. …”
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1042por Ding, Yi, Chen, MinChun, Wang, Min, Wang, MingMing, Zhang, Tiejun, Park, Jongsun, Zhu, YanRong, Guo, Chao, Jia, YanYan, Li, YuWen, Wen, AiDong“…Acetyl-11-Keto-β-Boswellic Acid (AKBA) is an active triterpenoid compound from the extract of Boswellia serrate. The present study was to determine whether AKBA, a novel Nrf2 activator, can protect against cerebral ischemic injury. …”
Publicado 2014
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1043por Beggs, Andrew D., Dilworth, Mark P., Domingo, Enric, Midgley, Rachel, Kerr, David, Tomlinson, Ian P.M., Middleton, Gary W.“…BRAF mutation is associated with the serrated tumour phenotype. We hypothesised that one of the mechanisms by which BRAF mutant colorectal cancer demonstrate poor outcomes with chemotherapy is abnormal gene methylation METHODS: The Cancer Genome Atlas (TCGA) methylation data was analysed using a linear regression model with BRAF mutation as an independent variable. …”
Publicado 2015
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1044por Kominami, Yoko, Yoshida, Shigeto, Tanaka, Shinji, Miyaki, Rie, Sanomura, Yoji, Seo, Min-Woong, Kagawa, Keiichiro, Kawahito, Shoji, Arimoto, Hidenobu, Yamada, Kenji, Chayama, Kazuaki“…METHODS: A total 107 colorectal tumours (44 adenomas, 43 adenocarcinomas with intramucosal invasion, and 20 sessile serrated adenoma/polyps [SSA/Ps]) in 98 patients who underwent endoscopic tumour resection were included. …”
Publicado 2015
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1045por Tomlinson, Ian“…Most of the approximately 13 high-penetrance genes that predispose to CRC primarily predispose to colorectal polyps, and each gene is associated with a specific type of polyp, whether conventional adenomas (APC, MUTYH, POLE, POLD1, NTHL1), juvenile polyps (SMAD4, BMPR1A), Peutz-Jeghers hamartomas (LKB1/STK11) and mixed polyps of serrated and juvenile types (GREM1). Lynch syndrome (MSH2, MLH1, MSH6, PMS2), by contrast, is associated primarily with cancer risk. …”
Publicado 2015
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1046por van Erp, Sanne J. H., Leicher, Laura W., Hennink, Simone D., Ghorbanoghli, Zeinab, Breg, Simone A. C., Morreau, Hans, Nielsen, Maartje, Hardwick, James C. H., Roukema, Jan A., Langers, Alexandra M. J., de Vos tot Nederveen Cappel, Wouter H., Vasen, Hans F. A.“…Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy. …”
Publicado 2016
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1047por Chin, Matthew, Karnes, William, Jamal, M Mazen, Lee, John G, Lee, Robert, Samarasena, Jason, Bechtold, Matthew L, Nguyen, Douglas L“…Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma (OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection (OR = 2.34 95%CI: 1.63-3.36; P < 0.001). …”
Publicado 2016
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1048por Purcell, Rachel V., Pearson, John, Aitchison, Alan, Dixon, Liane, Frizelle, Frank A., Keenan, Jacqueline I.“…Univariate analysis showed statistically significant associations between ETBF positivity and the presence of low-grade dysplasia (LGD), tubular adenomas (TA), and serrated polyps (P-values of 0.007, 0.027, and 0.007, respectively). …”
Publicado 2017
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1049por Hartmans, Elmire, Tjalma, Jolien J.J., Linssen, Matthijs D., Allende, Pilar Beatriz Garcia, Koller, Marjory, Jorritsma-Smit, Annelies, Nery, Mariana e Silva de Oliveira, Elias, Sjoerd G., Karrenbeld, Arend, de Vries, Elisabeth G.E., Kleibeuker, Jan H., van Dam, Gooitzen M., Robinson, Dominic J., Ntziachristos, Vasilis, Nagengast, Wouter B.“…Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. …”
Publicado 2018
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1050por Binh, Hoang Thi, Ngoc, Nguyen Van, Tagane, Shuichiro, Toyama, Hironori, Mase, Keiko, Mitsuyuki, Chika, Strijk, Joeri Sergej, Suyama, Yoshihisa, Yahara, Tetsukazu“…These new species are all phenotypically similar to Q. langbianensis s. str. in having lanceolate to oblanceolate leaf shape, upper 4–5/6–serrated leaf margin, acute or acuminate leaf apex and bracts of cupule arranged in 5–9 rings but distinguished both morphologically and phylogenetically. …”
Publicado 2018
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1051“…According to biopsies, a serrated adenoma and an invasive adenocarcinoma were reported in the ascending colon and sigmoid, respectively. …”
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1052por Wang, Yongyan, Shi, Chaonan, Yang, Tianxiao, Zhao, Lei, Chen, Jianhui, Zhang, Ning, Ren, Yan, Tang, Guiliang, Cui, Dangqun, Chen, Feng“…Specifically, STTM160 showed significantly smaller grain size, lower grain weight, shorter siliques length, shorter plant height, and more serrated leaves, whereas STTM165/166 showed decreased seed number, disabled siliques, and curled upward leaves.…”
Publicado 2018
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1053“…The new species can be distinguished from other hyalellid species by the following combination of characters: dorso-posterior flanges on pleonites I–III; palp on maxilla 1 reaching almost half of distance between base of palp and base of setae on outer plate, and two papposerrate setae on the inner margin of inner plate of maxilla 2; propodus of gnathopod 1 hammer-shaped, inner face with seven serrate setae; propodus of gnathopod 2 ovate; male uropod 1 without curved seta on inner side of inner ramus; ramus of uropod 3 shorter than peduncle; six pair of sternal gills on pereionites II–VII. …”
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1054por Matsuo, Kentaro, Taniguchi, Kohei, Hamamoto, Hiroki, Ito, Yuko, Futaki, Sugiko, Inomata, Yosuke, Shima, Takafumi, Asakuma, Mitsuhiro, Lee, Sang‐Woong, Tanaka, Keitaro, Okuda, Junji, Kondo, Yoichi, Uchiyama, Kazuhisa“…Delta‐like 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) group of Notch receptor ligands. …”
Publicado 2019
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1055por Ykema, Berbel, Rigter, Lisanne, Spaander, Manon, Moons, Leon, Bisseling, Tanya, Aleman, Berthe, de Boer, Jan Paul, Lugtenburg, Pieternella, Janus, Cecile, Petersen, Eefke, Roesink, Judith, Raemaekers, John, van der Maazen, Richard, Lansdorp-Vogelaar, Iris, Gini, Andrea, Verbeek, Wieke, Lemmens, Margriet, Meijer, Gerrit, van Leeuwen, Flora, Snaebjornsson, Petur, Carvalho, Beatriz, van Leerdam, Monique“…Advanced adenoma (AA), advanced serrated lesion (ASL), and AN (AA, ASL, CRC) were evaluated. …”
Publicado 2020
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1056por Alburquerque-González, Begoña, Bernabé-García, Manuel, Montoro-García, Silvia, Bernabé-García, Ángel, Rodrigues, Priscila Campioni, Ruiz Sanz, Javier, López-Calderón, Fernando F., Luque, Irene, Nicolas, Francisco José, Cayuela, María Luisa, Salo, Tuula, Pérez-Sánchez, Horacio, Conesa-Zamora, Pablo“…Serrated adenocarcinoma (SAC) is more invasive, has worse outcomes than conventional colorectal carcinoma (CRC), and is characterized by frequent resistance to anti-epidermal growth factor receptor (EGFR) and overexpression of fascin1, a key protein in actin bundling that plays a causative role in tumor invasion and is overexpressed in different cancer types with poor prognosis. …”
Publicado 2020
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1057por Murúa, Pedro, Edrada-Ebel, RuAngelie, Muñoz, Liliana, Soldatou, Sylvia, Legrave, Nathalie, Müller, Dieter G., Patiño, David J., can West, Pieter, Küpper, Frithjof C., Westermeier, Renato, Ebel, Rainer, Peters, Akira F.“…Externally, this hybrid exhibited typical features of its parents M. pyrifera (cylindrical and flexible distal stipes, serrate frond margins and presence of sporophylls) and L. spicata (rigid and flat main stipe and first bifurcation), as well as intermediate features between them (thick unfused haptera in the holdfast). …”
Publicado 2020
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1058por Toyoshima, Osamu, Nishizawa, Toshihiro, Yoshida, Shuntaro, Sekiba, Kazuma, Kataoka, Yosuke, Hata, Keisuke, Watanabe, Hidenobu, Tsuji, Yosuke, Koike, Kazuhiko“…Furthermore, more sessile serrated polyps detected by high-ADR endoscopists ( P = 0.041). …”
Publicado 2020
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1059por Rodríguez-Malagón, Marlenne A., Camprasse, Elodie C. M., Angel, Lauren P., Arnould, John P. Y.“…Five foraging metrics (maximum distance from the colony, bearing from the colony to the most distal point, tortuosity index, total number of dives and mean vectorial dynamic body acceleration were obtained using GPS tracking and accelerometry data in adult Australasian gannets (Morus serrator) from two colonies in southeastern Australia. …”
Publicado 2020
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1060“…Patients with KRAS mutation more frequently exhibited serrated and papillary architectures (P=0.009 and P=0.014, respectively). …”
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