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139641por Calderwood, Claire J., Wilson, James P., Fielding, Katherine L., Harris, Rebecca C., Karat, Aaron S., Mansukhani, Raoul, Falconer, Jane, Bergstrom, Malin, Johnson, Sarah M., McCreesh, Nicky, Monk, Edward J. M., Odayar, Jasantha, Scott, Peter J., Stokes, Sarah A., Theodorou, Hannah, Moore, David A. J.“…Of 5,290 identified records, 44 were included. Twenty-seven (61%) were RCTs and 17 (39%) were cohort studies. …”
Publicado 2021
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139642por Zhu, Na, Swietlik, Emilia M., Welch, Carrie L., Pauciulo, Michael W., Hagen, Jacob J., Zhou, Xueya, Guo, Yicheng, Karten, Johannes, Pandya, Divya, Tilly, Tobias, Lutz, Katie A., Martin, Jennifer M., Treacy, Carmen M., Rosenzweig, Erika B., Krishnan, Usha, Coleman, Anna W., Gonzaga-Juaregui, Claudia, Lawrie, Allan, Trembath, Richard C., Wilkins, Martin R., Morrell, Nicholas W., Shen, Yufeng, Gräf, Stefan, Nichols, William C., Chung, Wendy K.“…We also analyzed de novo variants in 124 pediatric trios enriched for IPAH and APAH-CHD. RESULTS: Seven genes with rare deleterious variants were associated with IPAH with false discovery rate smaller than 0.1: three known genes (BMPR2, GDF2, and TBX4), two recently identified candidate genes (SOX17, KDR), and two new candidate genes (fibulin 2, FBLN2; platelet-derived growth factor D, PDGFD). …”
Publicado 2021
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139643por Khan, Haroon Latif, Bhatti, Shahzad, Abbas, Sana, Kaloglu, Celal, Isa, Ahmed M., Younas, Hooria, Ziders, Rachel, Khan, Yousaf Latif, Hassan, Zahira, Turhan, Bilgün Oztürk, Yildiz, Aysegul, Aydin, Hikmet Hakan, Kalyan, Ender Yalcinkaya“…METHODS: This prospective study was designed to evaluate the expression profiles of seven extracellular miRNAs (miR-7-5p, miR-202-5p, miR-378-3p, miR-224, miR-320a, miR-212-3p, and miR-21-5p) in human follicular fluid (FF) to explore the outcomes of in vitro fertilization (IVF). …”
Publicado 2021
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139644por Huang, Tang-Hsiu, Kuo, Chin-Wei, Chen, Chian-Wei, Tseng, Yau-Lin, Wu, Chao-Liang, Lin, Sheng-Hsiang“…The relationship between baseline predictors and pulmonary function decline was determined. RESULTS: Fifty-seven patients were included, of whom 24 (42%) developed hepatic injury, 20 (35%) had AE-IPF, and 16 (28%) died on-treatment. …”
Publicado 2021
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139645por Jaradat, Nidal, Hawash, Mohammed, Abualhasan, Murad N., Qadi, Mohammad, Ghanim, Mustafa, Massarwy, Eman, Ammar, Suma Abu, Zmero, Noor, Arar, Mohammad, Hussein, Fatima, Issa, Linda, Mousa, Ahmed, Zarour, Abdulraziq“…Moreover, a broth microdilution assay was used to assess antimicrobial potentials against seven microbial strains. RESULTS: The GC/MS technique revealed the presence of 17 compounds from the AC collected from the Umm al-Fahm region and 13 compounds from the sample from the Baqa al-Gharbiyye region, while α-citral was the major component of both EOs, representing 47.62 and 43.46%, respectively. …”
Publicado 2021
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139646por Mendelsohn, Simon C, Fiore-Gartland, Andrew, Penn-Nicholson, Adam, Mulenga, Humphrey, Mbandi, Stanley Kimbung, Borate, Bhavesh, Hadley, Katie, Hikuam, Chris, Musvosvi, Munyaradzi, Bilek, Nicole, Erasmus, Mzwandile, Jaxa, Lungisa, Raphela, Rodney, Nombida, Onke, Kaskar, Masooda, Sumner, Tom, White, Richard G, Innes, Craig, Brumskine, William, Hiemstra, Andriëtte, Malherbe, Stephanus T, Hassan-Moosa, Razia, Tameris, Michèle, Walzl, Gerhard, Naidoo, Kogieleum, Churchyard, Gavin, Scriba, Thomas J, Hatherill, Mark“…Among 820 participants with valid RISK11 results, eight (1%) had prevalent tuberculosis at baseline: seven (2·5%; 95% CI 1·2–5·0) of 285 RISK11-positive participants and one (0·2%; 0·0–1·1) of 535 RISK11-negative participants. …”
Publicado 2021
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139647por Pulling Kuhn, Ann, Kim, Edward, Lane, Hannah G., Wang, Yan, Deitch, Rachel, Turner, Lindsey, Hager, Erin R., Parker, Elizabeth A.“…LPA and MVPA was assessed using 24-h ankle accelerometry (up to seven consecutive days). A sum score for teacher PA practices was assessed via survey (7 items; sum score range: 7–35; Cronbach’s alpha = 0.73; higher scores indicate more PA promoting practices). …”
Publicado 2021
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139648por Weber, Zachary T., Collier, Katharine A., Tallman, David, Forman, Juliet, Shukla, Sachet, Asad, Sarah, Rhoades, Justin, Freeman, Samuel, Parsons, Heather A., Williams, Nicole O., Barroso-Sousa, Romualdo, Stover, Elizabeth H., Mahdi, Haider, Cibulskis, Carrie, Lennon, Niall J., Ha, Gavin, Adalsteinsson, Viktor A., Tolaney, Sara M., Stover, Daniel G.“…METHODS: In this exploratory analysis, we characterize high-frequency ctDNA sample series collected over narrow time frames from seven patients with metastatic triple-negative breast cancer, each undergoing treatment with Cabozantinib, a multi-tyrosine kinase inhibitor (NCT01738438, https://clinicaltrials.gov/ct2/show/NCT01738438). …”
Publicado 2021
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139649por Gago-Veiga, AB, Huhn, J-I, Latysheva, N, Vieira Campos, A, Torres-Ferrus, M, Alpuente Ruiz, A, Sacco, S, Frattale, I, Ornello, R, Ruscheweyh, R, Marques, IB, Gryglas-Dworak, A, Stark, C, Gallardo, VJ, Pozo-Rosich, P“…METHODS: This is a multi-centre observational study carried out by neurologists from specialized headache units in seven countries, retrospective with consecutive inclusion of all patients presenting with a migraine diagnosis, over a period of three months. …”
Publicado 2021
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139650por Pinzón, Miguel Alejandro, Ortiz, Santiago, Holguín, Héctor, Betancur, Juan Felipe, Cardona Arango, Doris, Laniado, Henry, Arias Arias, Carolina, Muñoz, Bernardo, Quiceno, Julián, Jaramillo, Daniel, Ramirez, Zoraida“…Sample size was not calculated since the total population that met the inclusion criteria was evaluated. 111 patients were treated with the institutional protocol with intravenous dexamethasone 6 mg QD for seven to 10 days if they required oxygen. Since September 15, 2020, the hospitalization protocol of the clinic was modified by the Infectious Diseases and Pulmonology service, recommending a high dose of methylprednisolone of 250 to 500 mg every day for three days with a subsequent change to oral prednisone 50 mg every day for 14 days. …”
Publicado 2021
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139651por Ader, Florence, Peiffer-Smadja, Nathan, Poissy, Julien, Bouscambert-Duchamp, Maude, Belhadi, Drifa, Diallo, Alpha, Delmas, Christelle, Saillard, Juliette, Dechanet, Aline, Mercier, Noémie, Dupont, Axelle, Alfaiate, Toni, Lescure, François-Xavier, Raffi, François, Goehringer, François, Kimmoun, Antoine, Jaureguiberry, Stéphane, Reignier, Jean, Nseir, Saad, Danion, François, Clere-Jehl, Raphael, Bouiller, Kévin, Navellou, Jean-Christophe, Tolsma, Violaine, Cabié, André, Dubost, Clément, Courjon, Johan, Leroy, Sylvie, Mootien, Joy, Gaci, Rostane, Mourvillier, Bruno, Faure, Emmanuel, Pourcher, Valérie, Gallien, Sébastien, Launay, Odile, Lacombe, Karine, Lanoix, Jean-Philippe, Makinson, Alain, Martin-Blondel, Guillaume, Bouadma, Lila, Botelho-Nevers, Elisabeth, Gagneux-Brunon, Amandine, Epaulard, Olivier, Piroth, Lionel, Wallet, Florent, Richard, Jean-Christophe, Reuter, Jean, Staub, Thérèse, Lina, Bruno, Noret, Marion, Andrejak, Claire, Lê, Minh Patrick, Peytavin, Gilles, Hites, Maya, Costagliola, Dominique, Yazdanpanah, Yazdan, Burdet, Charles, Mentré, France“…The primary outcome was the clinical status at day 15, measured by the WHO seven-point ordinal scale. Secondary outcomes included quantification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory specimens and pharmacokinetic and safety analyses. …”
Publicado 2021
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139652por Saxena, Amit, Guttmann, Allison, Masson, Mala, Kim, Mimi Y, Haberman, Rebecca H, Castillo, Rochelle, Scher, Jose U, Deonaraine, Kristina K, Engel, Alexis J, Belmont, H Michael, Blazer, Ashira D, Buyon, Jill P, Fernandez-Ruiz, Ruth, Izmirly, Peter M“…Among 36 patients who were initially SARS-CoV-2 IgG positive, the majority maintained reactivity serially (88% up to 10 weeks, 83% up to 20 weeks, and 80% up to 30 weeks). Seven (70%) of ten patients with confirmed COVID-19 had antibody positivity beyond 30 weeks from disease onset. …”
Publicado 2021
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139653por Bosco, Agaba B., Anderson, Karen, Gresty, Karryn, Prosser, Christiane, Smith, David, Nankabirwa, Joaniter I., Nsobya, Sam, Yeka, Adoke, Namubiru, Rhoda, Arinaitwe, Emmanuel, Mbaka, Paul, Kissa, John, Lim, Chae Seung, Karamagi, Charles, Nakayaga, Joan K., Kamya, Moses R., Cheng, Qin“…METHODS: A total of 147 P. falciparum genomic DNA samples collected from cross-sectional surveys in symptomatic individuals of 2–10 years were characterized by genotyping of seven highly polymorphic neutral microsatellite markers (n = 85) and genetic sequencing of the Histidine Rich Protein 2 (pfhrp2) gene (n = 62). …”
Publicado 2021
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139654por Crous, P.W., Hernández-Restrepo, M., Schumacher, R.K., Cowan, D.A., Maggs-Kölling, G., Marais, E., Wingfield, M.J., Yilmaz, N., Adan, O.C.G., Akulov, A., Duarte, E. Álvarez, Berraf-Tebbal, A., Bulgakov, T.S., Carnegie, A.J., de Beer, Z.W., Decock, C., Dijksterhuis, J., Duong, T.A., Eichmeier, A., Hien, L.T., Houbraken, J.A.M.P., Khanh, T.N., Liem, N.V., Lombard, L., Lutzoni, F.M., Miadlikowska, J.M., Nel, W.J., Pascoe, I.G., Roets, F., Roux, J., Samson, R.A., Shen, M., Spetik, M., Thangavel, R., Thanh, H.M., Thao, L.D., van Nieuwenhuijzen, E.J., Zhang, J.Q., Zhang, Y., Zhao, L.L., Groenewald, J.Z.“…An order, family and genus are validated, seven new genera, 35 new species, two new combinations, two epitypes, two lectotypes, and 17 interesting new host and / or geographical records are introduced in this study. …”
Publicado 2021
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139655por Crea, Francesca, Panfili, Filippo Maria, Amodeo, Maria Elisa, Fintini, Danilo, Rossi, Francesco Paolo, Trenta, Italo, Menichella, Alessandra, Ossella, Chiara, Deidda, Andrea, Lidano, Roberta, Macchiarulo, Giulia, Lambiase, Caterina, Barbieri, Maria Antonietta, Raponi, Massimiliano“…Older children were more frequently symptomatic. Seven patients were admitted with MIS-C diagnosis. …”
Publicado 2021
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139656por Livingstone, Katherine M., Celis-Morales, Carlos, Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Forster, Hannah, Woolhead, Clara, O’Donovan, Clare B., Moschonis, George, Manios, Yannis, Traczyk, Iwona, Gundersen, Thomas E., Drevon, Christian A., Marsaux, Cyril F. M., Fallaize, Rosalind, Macready, Anna L., Daniel, Hannelore, Saris, Wim H. M., Lovegrove, Julie A., Gibney, Mike, Gibney, Eileen R., Walsh, Marianne, Brennan, Lorraine, Martinez, J. Alfredo, Mathers, John C.“…METHODS: Participants were recruited into a 6-month RCT across seven European countries (Food4Me) and were randomised to receive generalised dietary advice (control) or one of three levels of personalised nutrition advice (based on diet [L1], phenotype [L2] and genotype [L3]). …”
Publicado 2021
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139657por Pan, Hong-Xing, Liu, Jian-Kai, Huang, Bao-Ying, Li, Gui-Fan, Chang, Xian-Yun, Liu, Ya-Fei, Wang, Wen-Ling, Chu, Kai, Hu, Jia-Lei, Li, Jing-Xin, Zhu, Dan-Dan, Wu, Jing-Liang, Xu, Xiao-Yu, Zhang, Li, Wang, Meng, Tan, Wen-Jie, Huang, Wei-Jin, Zhu, Feng-Cai“…In the phase 1 trial, 13 (54%), 11 (46%), and seven (7/12) participants reported at least one adverse event (AE) after receiving 5-, 10-μg vaccine, or placebo, respectively. …”
Publicado 2021
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139658por Rodriguez-Smith, Jackeline J, Verweyen, Emely L, Clay, Gwendolyn M, Esteban, Ysabella M, de Loizaga, Sarah R, Baker, Elizabeth Joy, Do, Thuy, Dhakal, Sanjeev, Lang, Sean M, Grom, Alexei A, Grier, David, Schulert, Grant S“…FINDINGS: Between April 30, 2019, and Dec 14, 2020, we enrolled 19 patients with MIS-C (median age 9·0 years [IQR 4·5–15·0]; eight [42%] girls and 11 [58%] boys) and nine patients with Kawasaki disease (median age 2·0 years [2·0–4·0]); seven [78%] girls and two [22%] boys). Patients with MIS-C and Kawasaki disease had similar S100 proteins and IL-18 concentrations but patients with MIS-C were distinguished by significantly higher median concentrations of the IFNγ-induced CXCL9 (1730 pg/mL [IQR 604–6300] vs 278 pg/mL [54–477]; p=0·038). …”
Publicado 2021
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139659por Zhang, Yan, Zuo, Xiayun, Mao, Yanyan, Lian, Qiguo, Luo, Shan, Zhang, Shucheng, Tu, Xiaowen, Lou, Chaohua, Zhou, Weijin“…The prevalence of having ever experienced any of the reported seven CSA items was 12.9%. The preferred LCA model consisted of a three-class CSA latent variable, i.e. …”
Publicado 2021
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139660por Wang, Dachuan, Zhou, Kai, Xiang, Siqian, Zhang, Qiuli, Li, Ruxiang, Li, Miaomiao, Liang, Peixuan, Farkhanda, Naz, He, Guanghua, Ling, Yinghua, Zhao, Fangming“…RESULTS: A rice CSSL, Z749, with a dense and erect panicle phenotype, was identified among progeny of the recipient parent Nipponbare and the donor parent Xihui 18. Z749 carried seven substitution segments (average length 2.12 Mb). …”
Publicado 2021
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