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  1. 140281
    “…Patients were excluded if they were being treated for an inhibitor with immune tolerance therapy (ITT), coagulation factor VIIa (recombinant) (NovoSeven(1)), anti-inhibitor coagulant complex (Feiba(2)) or emicizumab-kxwh (Hemlibra(3)). …”
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    Comparison of extended to standard half-life recombinant factor VIII therapy in patients with hemophilia A on prophylactic therapy
  2. 140282
    “…RESULTS/ANTICIPATED RESULTS: Seventy-seven percent of the IDP CTSA’s responded to the online survey, led by University of Rochester, and the results can be summarized as follows: (1) 100% agreed that the IDP process is important and should be considerably improved to optimize effectiveness; (2) a range of diverse IDP formats are utilized, making comparisons across programs difficult; (3) 50% of CTSA hubs report only fair to good compliance with the IDP process; (4) a major barrier to the IDP process is lack of instruction regarding how best to utilize; (5) poor alignment of currently available IDPs designed for basic science PhDs with CTS investigators; (6) an absence of a CTS specific IDP to best foster RCD for this specific career trajectory. …”
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    2502 The need for an evidence-based CTS specific IDP for early career training and for a long-term and sustainable career in clinical translational sciences
  3. 140283
    “…RESULTS: At baseline, there were 457 recently-delivered women in the six village clusters receiving home visit care and 214 in the seven village clusters receiving home visit care plus group antenatal care. …”
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    The power of peers: an effectiveness evaluation of a cluster-controlled trial of group antenatal care in rural Nepal
  4. 140284
    por Howard, Ian
    Publicado 2019
    “…It consists of a single dedicated purpose-built ambulance, manned and run 24 hours a day, seven days a week by a variety of staff from both HMCAS and the CCN and deployed primarily for the transfer and retrieval of critical care patients across Qatar.(19) The program was further developed in 2016 and formalized under the Transfer and Retrieval division of the HMCAS, with dedicated HMCAS and CCN staff receiving bespoke training and continued education;(18) the addition of specialized and dedicated communications staff for call taking, dispatch and monitoring; and focused governance and audit to maintain the highest quality of patient safety and quality of care. …”
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    Taking upstairs care outside
  5. 140285
    “…We also used data from 16 patients enrolled at seven of the 34 sites during the pilot study between Jan 15, 2014, and April 10, 2014. 168 patients were randomly assigned to the hIVIG group and 161 to the placebo group. 21 patients were excluded (12 from the hIVIG group and 9 from the placebo group) because they did not receive an infusion or their eligibility could not be confirmed. …”
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    Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial
  6. 140286
    “…SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, PsycINFO, and seven other published or grey literature databases, as well as trial registries and key websites, up to 23 July 2018, followed by citation searches. …”
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    Altering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption
  7. 140287
    por Howard, James F., Nowak, Richard J., Wolfe, Gil I., Freimer, Miriam L., Vu, Tuan H., Hinton, John L., Benatar, Michael, Duda, Petra W., MacDougall, James E., Farzaneh-Far, Ramin, Kaminski, Henry J., Barohn, Richard, Dimachkie, Mazen, Pasnoor, Mamatha, Farmakidis, Constantine, Liu, Tina, Colgan, Samantha, Benatar, Michael G., Bertorini, Tulio, Pillai, Rekha, Henegar, Robert, Bromberg, Mark, Gibson, Summer, Janecki, Teresa, Freimer, Miriam, Elsheikh, Bakri, Matisak, Paige, Genge, Angela, Guidon, Amanda, David, William, Habib, Ali A., Mathew, Veena, Mozaffar, Tahseen, Hinton, John L., Hewitt, William, Barnett, Deborah, Sullivan, Patricia, Ho, Doreen, Howard, James F., Traub, Rebecca E., Chopra, Manisha, Kaminski, Henry J., Aly, Radwa, Bayat, Elham, Abu-Rub, Mohammad, Khan, Shaida, Lange, Dale, Holzberg, Shara, Khatri, Bhupendra, Lindman, Emily, Olapo, Tayo, Sershon, Lisa M., Lisak, Robert P., Bernitsas, Evanthia, Jia, Kelly, Malik, Rabia, Lewis-Collins, Tiffany D., Nicolle, Michael, Nowak, Richard J., Sharma, Aditi, Roy, Bhaskar, Nye, Joan, Pulley, Michael, Berger, Alan, Shabbir, Yasmeen, Sachdev, Amit, Patterson, Kimberly, Siddiqi, Zaeem, Sivak, Mark, Bratton, Joan, Small, George, Kohli, Anem, Fetter, Mary, Vu, Tuan, Lam, Lucy, Harvey, Brittany, Wolfe, Gil I., Silvestri, Nicholas, Patrick, Kara, Zakalik, Karen, Duda, Petra W., MacDougall, James, Farzaneh-Far, Ramin, Pontius, Angela, Hoarty, Michelle
    Publicado 2020
    “…DESIGN, SETTING, AND PARTICIPANTS: This randomized, double-blind, placebo-controlled phase 2 clinical trial at 25 study sites across North America recruited participants between December 2017 and August 2018. Fifty-seven patients were screened, of whom 12 did not meet inclusion criteria and 1 was lost to follow-up after randomization but before receiving study drug, resulting in a total of 44 acetylcholine receptor autoantibody (AChR-Ab)–positive patients with gMG with baseline Quantitative Myasthenia Gravis (QMG) scores of at least 12, regardless of treatment history. …”
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    Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial
  8. 140288
    “…Late changes in lateral flow serological assay bands were recorded in 74 (9·3%) of 800 cassettes (35 [8·8%] of 400 Encode assays; 39 [9·8%] of 400 Onsite assays), but only seven (all Onsite assays) of these changes were concordant with the laboratory immunoassay. …”
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    Point-of-care serological assays for delayed SARS-CoV-2 case identification among health-care workers in the UK: a prospective multicentre cohort study
  9. 140289
    “…WGR result indicated that compared to wild-type ZM4, 3.5M and 3.6M have seven and five single nucleotide polymorphisms (SNPs), respectively, among which four are shared in common. …”
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    Development and characterization of acidic-pH-tolerant mutants of Zymomonas mobilis through adaptation and next-generation sequencing-based genome resequencing and RNA-Seq
  10. 140290
    Publicado 2020
    “…We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. …”
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    Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019
  11. 140291
    “…We recruited participants from seven UK National Health Service Trust sites. Participants were aged 14–18 years; help-seeking; had presented with first-episode psychosis in the past year; were under the care of a psychiatrist; were showing current psychotic symptoms; and met ICD-10 criteria for schizophrenia, schizoaffective disorder, or delusional disorder, or met the entry criteria for an early intervention for psychosis service. …”
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    Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
  12. 140292
    “…As of Aug 28, 2020, eight serious adverse events, considered unrelated to vaccination, have been reported by seven (2%) participants. In phase 1, seroconversion after the second dose was observed in 24 of 24 participants (100·0% [95% CI 85·8–100·0]) in the 3 μg group and 22 of 23 (95·7% [78·1–99·9]) in the 6 μg group. …”
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    Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial
  13. 140293
    por Gillentine, Madelyn A., Wang, Tianyun, Hoekzema, Kendra, Rosenfeld, Jill, Liu, Pengfei, Guo, Hui, Kim, Chang N., De Vries, Bert B. A., Vissers, Lisenka E. L. M., Nordenskjold, Magnus, Kvarnung, Malin, Lindstrand, Anna, Nordgren, Ann, Gecz, Jozef, Iascone, Maria, Cereda, Anna, Scatigno, Agnese, Maitz, Silvia, Zanni, Ginevra, Bertini, Enrico, Zweier, Christiane, Schuhmann, Sarah, Wiesener, Antje, Pepper, Micah, Panjwani, Heena, Torti, Erin, Abid, Farida, Anselm, Irina, Srivastava, Siddharth, Atwal, Paldeep, Bacino, Carlos A., Bhat, Gifty, Cobian, Katherine, Bird, Lynne M., Friedman, Jennifer, Wright, Meredith S., Callewaert, Bert, Petit, Florence, Mathieu, Sophie, Afenjar, Alexandra, Christensen, Celenie K., White, Kerry M., Elpeleg, Orly, Berger, Itai, Espineli, Edward J., Fagerberg, Christina, Brasch-Andersen, Charlotte, Hansen, Lars Kjærsgaard, Feyma, Timothy, Hughes, Susan, Thiffault, Isabelle, Sullivan, Bonnie, Yan, Shuang, Keller, Kory, Keren, Boris, Mignot, Cyril, Kooy, Frank, Meuwissen, Marije, Basinger, Alice, Kukolich, Mary, Philips, Meredith, Ortega, Lucia, Drummond-Borg, Margaret, Lauridsen, Mathilde, Sorensen, Kristina, Lehman, Anna, Lopez-Rangel, Elena, Levy, Paul, Lessel, Davor, Lotze, Timothy, Madan-Khetarpal, Suneeta, Sebastian, Jessica, Vento, Jodie, Vats, Divya, Benman, L. Manace, Mckee, Shane, Mirzaa, Ghayda M., Muss, Candace, Pappas, John, Peeters, Hilde, Romano, Corrado, Elia, Maurizio, Galesi, Ornella, Simon, Marleen E. H., van Gassen, Koen L. I., Simpson, Kara, Stratton, Robert, Syed, Sabeen, Thevenon, Julien, Palafoll, Irene Valenzuela, Vitobello, Antonio, Bournez, Marie, Faivre, Laurence, Xia, Kun, Earl, Rachel K., Nowakowski, Tomasz, Bernier, Raphael A., Eichler, Evan E.
    Publicado 2021
    “…Utilizing protein homology, mutation analyses, gene expression analyses, and phenotypic characterization, we provide evidence for variation in 12 HNRNP genes as candidates for NDDs. Seven are potentially novel while the remaining genes in the family likely do not significantly contribute to NDD risk. …”
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    Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders
  14. 140294
    por Lopes, Renato D, de Barros e Silva, Pedro Gabriel Melo, Furtado, Remo H M, Macedo, Ariane Vieira Scarlatelli, Bronhara, Bruna, Damiani, Lucas Petri, Barbosa, Lilian Mazza, de Aveiro Morata, Júlia, Ramacciotti, Eduardo, de Aquino Martins, Priscilla, de Oliveira, Aryadne Lyrio, Nunes, Vinicius Santana, Ritt, Luiz Eduardo Fonteles, Rocha, Ana Thereza, Tramujas, Lucas, Santos, Sueli V, Diaz, Dario Rafael Abregu, Viana, Lorena Souza, Melro, Lívia Maria Garcia, de Alcântara Chaud, Mariana Silveira, Figueiredo, Estêvão Lanna, Neuenschwander, Fernando Carvalho, Dracoulakis, Marianna Deway Andrade, Lima, Rodolfo Godinho Souza Dourado, de Souza Dantas, Vicente Cés, Fernandes, Anne Cristine Silva, Gebara, Otávio Celso Eluf, Hernandes, Mauro Esteves, Queiroz, Diego Aparecido Rios, Veiga, Viviane C, Canesin, Manoel Fernandes, de Faria, Leonardo Meira, Feitosa-Filho, Gilson Soares, Gazzana, Marcelo Basso, Liporace, Idelzuíta Leandro, de Oliveira Twardowsky, Aline, Maia, Lilia Nigro, Machado, Flávia Ribeiro, de Matos Soeiro, Alexandre, Conceição-Souza, Germano Emílio, Armaganijan, Luciana, Guimarães, Patrícia O, Rosa, Regis G, Azevedo, Luciano C P, Alexander, John H, Avezum, Alvaro, Cavalcanti, Alexandre B, Berwanger, Otavio
    Publicado 2021
    “…The primary safety outcome of major or clinically relevant non-major bleeding occurred in 26 (8%) patients assigned therapeutic anticoagulation and seven (2%) assigned prophylactic anticoagulation (relative risk 3·64 [95% CI 1·61–8·27], p=0·0010). …”
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    Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial
  15. 140295
    “…INTERVENTION AND COMPARATOR: Sixty eligible patients will be randomly assigned, in a 1:1 ratio, to receive curcumin-piperine capsules (three capsules/day; each capsules containing 500 mg curcumin plus 5 mg piperine; in total 1500 mg curcumin and 15 mg piperine/daily) for seven days (n=30) or matching placebo capsules (three capsules/day; each capsules containing 505 mg maltodextrin; totally 1515 mg, maltodextrin/ daily) for same duration (n=30). …”
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    Effect of curcumin-pipeine supplementation on clinical status, mortality rate, oxidative stress, and inflammatory markers in critically ill ICU patients with COVID-19: a structured summary of a study protocol for a randomized controlled trial
  16. 140296
    “…Search in the Complement Database revealed seven patients, each carrying one pathogenic or likely pathogenic variant in C3, CD46, DGKE, and CFH. …”
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    Thrombotic Microangiopathy Variants Are Independently Associated with Critical Disease in COVID-19 Patients
  17. 140297
    “…The most commonly assigned COMCATs by InterVA-5 were emergencies (68 [48%] of 143 deaths) and health systems (62 [43%] deaths), and by physician review (India only) were health systems (seven [44%] of 16 deaths) and inevitability (five [31%] deaths); agreement between InterVA-5 and physician review (India data only) was poor (κ=0·04 [0·00–0·15]). …”
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    Causes and circumstances of maternal death: a secondary analysis of the Community-Level Interventions for Pre-eclampsia (CLIP) trials cohort
  18. 140298
    por Thayyil, Sudhin, Pant, Stuti, Montaldo, Paolo, Shukla, Deepika, Oliveira, Vania, Ivain, Phoebe, Bassett, Paul, Swamy, Ravi, Mendoza, Josephine, Moreno-Morales, Maria, Lally, Peter J, Benakappa, Naveen, Bandiya, Prathik, Shivarudhrappa, Indramma, Somanna, Jagadish, Kantharajanna, Usha B, Rajvanshi, Ankur, Krishnappa, Sowmya, Joby, Poovathumkal K, Jayaraman, Kumutha, Chandramohan, Rema, Kamalarathnam, Chinnathambi N, Sebastian, Monica, Tamilselvam, Indumathi A, Rajendran, Usha D, Soundrarajan, Radhakrishnan, Kumar, Vignesh, Sudarsanan, Harish, Vadakepat, Padmesh, Gopalan, Kavitha, Sundaram, Mangalabharathi, Seeralar, Arasar, Vinayagam, Prakash, Sajjid, Mohamed, Baburaj, Mythili, Murugan, Kanchana D, Sathyanathan, Babu P, Kumaran, Elumalai S, Mondkar, Jayashree, Manerkar, Swati, Joshi, Anagha R, Dewang, Kapil, Bhisikar, Swapnil M, Kalamdani, Pavan, Bichkar, Vrushali, Patra, Saikat, Jiwnani, Kapil, Shahidullah, Mohammod, Moni, Sadeka C, Jahan, Ismat, Mannan, Mohammad A, Dey, Sanjoy K, Nahar, Mst N, Islam, Mohammad N, Shabuj, Kamrul H, Rodrigo, Ranmali, Sumanasena, Samanmali, Abayabandara-Herath, Thilini, Chathurangika, Gayani K, Wanigasinghe, Jithangi, Sujatha, Radhika, Saraswathy, Sobhakumar, Rahul, Aswathy, Radha, Saritha J, Sarojam, Manoj K, Krishnan, Vaisakh, Nair, Mohandas K, Devadas, Sahana, Chandriah, Savitha, Venkateswaran, Harini, Burgod, Constance, Chandrasekaran, Manigandan, Atreja, Gaurav, Muraleedharan, Pallavi, Herberg, Jethro A, Kling Chong, W K, Sebire, Neil J, Pressler, Ronit, Ramji, Siddarth, Shankaran, Seetha
    Publicado 2021
    “…METHODS: We did a multicountry open-label, randomised controlled trial in seven tertiary neonatal intensive care units in India, Sri Lanka, and Bangladesh. …”
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    Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh
  19. 140299
    “…CGS will be recorded on a seven-point scale; grade 1 (not hospitalized, no evidence of infection and resumption of normal activities), grade 2 (not hospitalized, but unable to resume normal activities), grade 3 (hospitalized, not requiring supplemental oxygen), grade 4 (hospitalized, requiring supplemental oxygen), grade 5 (hospitalized, requiring nasal high-flow oxygen therapy and/or noninvasive mechanical ventilation), grade 6 (hospitalized, requiring ECMO and/or invasive mechanical ventilation) and grade 7 (death). …”
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    Anti-COVID property of subcutaneous ivermectin in synergy with zinc among midlife moderately symptomatic patients: a structured summary of a study protocol for a randomised controlled trial
  20. 140300
    “…The primary outcome was the clinical status at day 15 measured by the WHO seven-point ordinal scale, assessed in the intention-to-treat population. …”
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    Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial
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