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832641por Liira, Juha, Verbeek, Jos H., Costa, Giovanni, Driscoll, Tim R., Sallinen, Mikael, Isotalo, Leena K., Ruotsalainen, Jani H.“…Modafinil probably has similar effects on sleepiness (KSS) (MD -0.90, 95% CI -1.45 to -0.35; one trial, 183 participants, moderate quality evidence) and alertness in the psychomotor vigilance test in the same patient group. Post-marketing, severe skin reactions have been reported. Adverse effects reported by trial participants were headache, nausea and a rise in blood pressure. …”
Publicado 2014
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832642“…Despite the fact that several primary studies have been conducted on the incidence rate of tuberculosis in HIV-infected people in Sub-Saharan Africa, the regional-level tuberculosis incidence rate remains unknown. …”
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832643“…BACKGROUND: The poorer physical health of autistic adults compared to non-autistic adults has been highlighted by several epidemiological studies. However, research has so far been limited to specific geographical areas and has primarily focused on young autistic individuals (aged 35 years and younger). …”
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832644por Etemad, Leila L., Yue, John K., Barber, Jason, Nelson, Lindsay D., Bodien, Yelena G., Satris, Gabriela G., Belton, Patrick J., Madhok, Debbie Y., Huie, J. Russell, Hamidi, Sabah, Tracey, Joye X., Coskun, Bukre C., Wong, Justin C., Yuh, Esther L., Mukherjee, Pratik, Markowitz, Amy J., Huang, Michael C., Tarapore, Phiroz E., Robertson, Claudia S., Diaz-Arrastia, Ramon, Stein, Murray B., Ferguson, Adam R., Puccio, Ava M., Okonkwo, David O., Giacino, Joseph T., McCrea, Michael A., Manley, Geoffrey T., Temkin, Nancy R., DiGiorgio, Anthony M.“…Risk factors for postindex TBI were psychiatric history, preindex TBI, and extracranial injury severity. At 1 year, compared with those without postindex TBI, participants with postindex TBI had worse functional recovery (GOSE score of 8: adjusted relative risk, 0.57; 95% CI, 0.34-0.96) and health-related quality of life (QOLIBRI-OS: aMD, −15.9; 95% CI, −22.6 to −9.1), and greater postconcussive symptoms (RPQ: aMD, 8.1; 95% CI, 4.2-11.9), psychological distress symptoms (BSI-18: aMD, 5.3; 95% CI, 2.1-8.6), depression symptoms (PHQ-9: aMD, 3.0; 95% CI, 1.5-4.4), and PTSD symptoms (PCL-5: aMD, 7.8; 95% CI, 3.2-12.4). …”
Publicado 2023
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832645por Wittek, Laura, Touma, Chadi, Nitezki, Tina, Laeger, Thomas, Krämer, Stephanie, Raila, Jens“…In the frame of a multifactorial approach for severity assessment, parameters such as body weight, body composition, food intake, cage and body surface temperature (thermal imaging), mRNA expression of uncoupling protein 1 (Ucp1) in brown adipose tissue (BAT), fur score, and fecal corticosterone metabolites (CMs) were included. …”
Publicado 2023
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832646“…Studies have shown that hypogonadic patients have more severe osteoporosis and predominant involvement of the femoral neck. …”
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832647por Marler, Jennifer D, Fujii, Craig A, Utley, MacKenzie T, Balbierz, Daniel J, Galanko, Joseph A, Utley, David S“…RESULTS: Participants comprised 188 smokers (n=94, 50% in the Pivot group and n=94, 50% in the QuitGuide group; mean age 46.4, SD 9.2 years; n=104, 55.3% women; n=128, 68.1% White individuals; mean CPD 17.6, SD 9.0). Several cessation rates were higher in the Pivot group (intention to treat): self-reported continuous abstinence was 20% (19/94) versus 9% (8/94; P=.03) for QuitGuide, biochemically confirmed abstinence was 31% (29/94) versus 18% (17/94; P=.04) for QuitGuide, and biochemically confirmed continuous abstinence was 19% (18/94) versus 9% (8/94; P=.046) for QuitGuide. …”
Publicado 2023
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832648por Kulkarni, Prasad S., Gunale, Bhagwat, Kohli, Sunil, Lalwani, Sanjay, Tripathy, Srikanth, Kar, Sonali, Raut, Sidram, Kulkarni, Praveen, Apte, Aditi, Bavdekar, Ashish, Bhalla, Hira Lal, Plested, Joyce S., Cloney-Clark, Shane, Zhu, MingZhu, Kalkeri, Raj, Pryor, Melinda, Hamilton, Stephanie, Thakar, Madhuri, Sannidhi, Ranga S., Baranwal, Punjita, Bhamare, Chetanraj, Dharmadhikari, Abhijeet, Gupta, Manish, Poonawalla, Cyrus S., Shaligram, Umesh, Kapse, Dhananjay“…Solicited adverse events reported were transient and mostly mild in severity in all the groups. No causally related SAE was reported. …”
Publicado 2023
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832649“…Conclusion: Clinical phenotype of patients with heterozygous variants of Semaphorins and its receptors shows presence of severe obesity from a young age of 2-4 yrs. All had a very strong family history of morbid obesity. …”
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832650por Simeoli, Chiara, Di Paola, Nicola, Stigliano, Antonio, Lardo, Pina, Kearney, Tara, Mezosi, Emese, Ghigo, Ezio, Giordano, Roberta, Mariash, Cary N, Donegan, Diane, Feelders, Richard A, Hand, Austin L, Moraitis, Andreas G, Pivonello, Rosario“…Hypercoagulability persists for several months (mos) after curative surgery, and current CS treatment guidelines recommend anticoagulation therapy for up to 3 mos after surgery. …”
Publicado 2023
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832651por Basnet, Jelina, Rezq, Samar, Huffman, Alexandra M, Asala, Tolulope E, Yanes Cardozo, Licy L, Romero, Damian G“…Targeting the AR may alleviate PCOS complications; however, the use of AR blockers is limited by their severe adverse effects in females; thus, safer alternative approaches are highly needed. …”
Publicado 2023
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832652por De Andrade, Nathalia Liberatoscioli Menezes, de Assis Funari, Mariana Ferreira, Malaquias, Alexsandra, Branco Dantas, Naiara Castelo, Rezende, Raissa, de Polli Cellin, Laurana, Homma, Thais Kataoka, Lerario, Antonio Marcondes, Arnhold, Ivo J, Vasques, Gabriela Andrade, Lima Jorge, Alexander Augusto“…Variants associated with syndromic SS were widely distributed in several rare conditions, affecting 63 different genes: COL2A1 in 3 patients; ANKRD11; BCL11B; LTBP3; CHD7; PTPN11; PUF60; SRCAP; STAT5B, GNAS in two patients each; SCN1A; SETD5; PTHLH; GINS1; ZMYM2; TERT; G6PC3; KIF11; SCUBE3; TBC1D32; PDHA1; RPS6KA3; SMARCA4; DNM2; KMT2A ; IHH; BRCA1; NF1; INPP5K; KRAS; FGFR2; DPH1; RPL5; KDM5C; DYRK1A; MVK; FBN1; AFF4; ACTB; POC1A; IGF1R; CREBBP; POLD1; POLR3B; PCNA; CUL7; RUNX2; EXT1; GH1; FGD1; BLM; CHRNG in one patient each. …”
Publicado 2023
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832653por Roth, Christian L, Shoemaker, Ashley H, Gottschalk, Michael, Miller, Jennifer, Yuan, Guojun, Malhotra, Sonali, Scimia, Cecilia, Jennifer Abuzzahab, M“…Background: Hypothalamic obesity (HO) is an acquired form of severe obesity that can occur following surgical resection or radiotherapy of brain tumors. …”
Publicado 2023
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832654por Batista, Rafael Loch, Almeida Gomes, Nathalia Lisboa Rosa, Bachega, Tania A, Madureira, Guiomar, de Miranda, Mirela Costa, Thomazini Dallago, Renata T Dallago, Martins Ferrari, Maria Tereza, Lousada, Lia Mesquita, Craveiro, Flora Ladeira, Pereira Batatinha, Júlio Américo, Cunha Scalco, Renata Da, Frade Costa, Elaine Maria, Sircili, Maria Helena P, Denes, Francisco T, Inacio, Marlene, Nishi, Mirian Yumie, Domenice, Sorahia, Mendonca, Berenice Bilharinho“…Context: DSD represent a wide range of conditions presenting at different ages to many health professionals with several backgrounds. Establishing a correct diagnosis is essential for appropriate management. …”
Publicado 2023
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832655por Domé, Laila, Riaño Gomez, Juan Manuel, Marta Bonaventura, María, Olga Fernandez, Marina, Daniel Montaner, Alejandro, Adela Lux-Lantos, Victoria, Silvia Bianchi, Maria“…We have shown that the immunomodulatory oligonucleotide IMT504 (IMT) improves glucose homeostasis in several animal models of type 1 diabetes by regulating immunomodulatory factors and by improving beta-cell function. …”
Publicado 2023
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832656por Alfitian, Jonas, Riedel, Bernhard, Ismail, Hilmy, Ho, Kwok M., Xie, Sophia, Zimmer, Philipp, Kammerer, Tobias, Wijeysundera, Duminda N., Cuthbertson, Brian H., Schier, Robert“…Logistic regression models were analyzed for the association of low peak VO(2) with moderate-to-severe in-hospital postoperative complications. Optimal sex-specific peak VO(2) thresholds were obtained by maximizing the Youden index of receiver operating characteristic (ROC) curves. …”
Publicado 2023
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832657“…There was no significant difference in headache severity, quality, headache nature, unilateral/bilateral, and headache duration either in inter-IH or peri-ictal headache (Peri-IH) between the two groups. …”
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832658Publicado 2020“…There are not many researchers on Chinese medical history in Korean academia. As several researchers have led the study, the study’s concentration on specific periods or specific themes cannot be denied. …”
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832659por Zhu, Lanlan, Li, Ping, Zhang, Guangyi, He, Zhiyong, Tao, Xingyu, Ji, Yicheng, Yang, Wenjing, Zhu, Xiaofang, Luo, Wanying, Liao, Wenjian, Chen, Chuanhui, Liu, Yang, Zhang, Wei“…Antimicrobial susceptibility tests revealed that these isolates consistently resisted several drugs, notably TCC, TZP, CAZ, and COL. Additionally, 85% resisted both DOX and TOB. …”
Publicado 2023
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832660por Zeng, Ting, Lu, Yaoqin, Zhao, Yanji, Guo, Zihao, Sun, Shengzhi, Teng, Zhidong, Tian, Maozai, Wang, Jun, Li, Shulin, Fan, Xucheng, Wang, Weiming, Cai, Yongli, Liao, Gengze, Liang, Xiao, He, Daihai, Wang, Kai, Zhao, Shi“…BACKGROUND: Although COVID-19 vaccines and their booster regimens protect against symptomatic infections and severe outcomes, there is limited evidence about their protection against asymptomatic and symptomatic infections in real-world settings, particularly when considering that the majority of SARS-CoV-2 Omicron infections were asymptomatic. …”
Publicado 2023
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