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  1. 832661
    “…Besides, ASK1-K716R effectively suppressed the infiltration of peripheral immune cells into the brain parenchyma, decreased the number of proinflammatory-like microglia/macrophages, increased the number of anti-inflammatory-like microglia/macrophages, and downregulated expression of several proinflammatory factors. Furthermore, ASK1-K716R attenuated white matter injury and improved the nerve conduction function of both myelinated and unmyelinated fibers after TBI. …”
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    ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood–brain barrier integrity after traumatic brain injury
  2. 832662
    “…Time-dependent ROC curves for OS and PFS for landmark times of 20 months and 6 months, respectively, revealed AUC of 0.531, 0.756, 0.774 for OS and 0.535, 0.723, 0.806 for PFS for protein expression, clinical factors, and the combination of protein expression and clinical factors, respectively, indicating that the proteome can provide additional survival risk discrimination to that already provided by the standard clinical factors with a greater impact on PFS. Several proteins of interest were identified. Alterations in GALNT14 (increased) and CCL17 (decreased) (p = 0.003 and 0.003, respectively, FDR 0.198 for both) were associated with an improvement in both OS and PFS. …”
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    Revisiting Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients with Glioblastoma—Proteomic Alteration and Comparison Analysis with the Standard-of-Care Chemoirradiation
  3. 832663
    “…DESIGN, SETTING, AND PARTICIPANTS: This cohort study used datalogs collected from children with cochlear implants during clinical visits to a tertiary pediatric hospital in Toronto, Ontario, Canada, from January 1, 2018, to November 11, 2021. Children with severe to profound hearing loss using cochlear implants were studied because their devices monitored and cataloged levels and types of sounds during hourly use per day (datalogs) and because their hearing and spoken language development was particularly vulnerable to reduced sound exposure. …”
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    Exposure to Spoken Communication During the COVID-19 Pandemic Among Children With Cochlear Implants
  4. 832664
    “…SETTING: CORIMUNO-19 cohort (publicly supported platform of open label, randomised controlled trials of immune modulatory drugs in patients admitted to hospital with moderate or severe covid-19 disease) based on 19 university and general hospitals across France, from 16 April 2020 to 21 April 2021. …”
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    Use of covid-19 convalescent plasma to treat patients admitted to hospital for covid-19 with or without underlying immunodeficiency: open label, randomised clinical trial
  5. 832665
    “…Intratracheal administration of corticosteroid admixed with exogenous surfactant could overcome these concerns by minimizing systemic sequelae. Several small, randomized trials have found intratracheal budesonide in a surfactant vehicle to be a promising therapy to increase survival free of BPD. …”
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    Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: statistical analysis plan for the international, multicenter, randomized PLUSS trial
  6. 832666
    “…EXPOSURE: Accidental mild complicated-severe TBI (msTBI) for those in the TBI group. Some controls received a diagnosis of orthopedic injury. …”
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    Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury
  7. 832667
    “…Women with cardiometabolic conditions and co-occurring ADHD had, compared with those without ADHD, substantially increased prevalence of (a) all measured mood and anxiety disorders, e.g., depression (PR = 2.38, 95% CI 2.19–2.58), bipolar disorder (PR = 4.81, 95% CI 3.65–6.35), posttraumatic stress disorder (PR = 2.78, 95% CI 2.52–3.07), social phobia (PR = 2.96, 95% CI 2.64–3.32); (b) moderate/severe depressive, anxiety, and PTSD symptoms with PR = 1.76 (95% CI 1.67–1.85), PR = 1.97 (95% CI 1.82–2.12), and PR = 2.01 (95% CI 1.88–2.15), respectively; (c) alcoholism/SUD, PR = 4.79 (95% CI 3.90–5.89); and (d) self-harm, PR = 1.47 (95% CI 1.29–1.67) and suicide attempts, PR = 2.37 (95% CI 2.05–2.73). …”
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    Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study
  8. 832668
    “…More adequately powered, well− designed clinical trials to increase the quality of the available evidence are still needed in the future due to several limitations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13020-023-00850-5.…”
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    Comparative efficacy of Chinese patent medicines in patients with carotid atherosclerotic plaque: a Bayesian network meta− analysis
  9. 832669
    “…Despite adjustment for several confounders, women were more likely to be overweight (OR: 2.18; CI: 1.86, 2.55) and obese (OR: 3.79; CI: 2.86, 5.03) than men. …”
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    Gender-specific determinants of overweight and obesity among older adults in India: evidence from a cross-sectional survey, 2017-18
  10. 832670
    “…BACKGROUND: Adults aged > 50 years are at increased risk for severe coronavirus disease 2019 (COVID-19). This study evaluated immunogenicity of COVID-19 vaccines in healthy adults aged > 50 years through quantification of antigen specific antibody concentration and function post-vaccination with two, three and four COVID-19 vaccine doses. …”
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    1158. Immunogenicity of COVID-19 vaccine four-dose series in healthy community dwelling adults 50 years and above: interim analysis from the ‘PRospEctiVe EvaluatioN of immuniTy after COVID-19 vaccines’ (PREVENT-COVID) study
  11. 832671
    “…BACKGROUND: Extrapulmonary or disseminated coccidioidomycosis (cocci) is a rare, severe form of fungal disease acquired by inhaling spores of Coccidioides spp., a dimorphic fungus endemic in the southwest United States (US) and parts of Central/South America. …”
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    2516. Development of a de novo Patient-Reported Outcome (PRO) Measure to Assess the Impacts of Disseminated Coccidioidomycosis [Valley Fever] on Patients Living with the Condition
  12. 832672
    “…The primary endpoint was the change in total severity score of 8 subjective symptoms. Secondary endpoints include the change of each subjective symptom, SARS-CoV-2 viral loads, pDC activation, serum SARS-CoV-2 specific antibodies, type I interferons, and the proportion of subjects with emergency room visits or who were hospitalized. …”
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    552. Effect of Lactococcus lactis strain plasma (LC- Plasma) on immune response and symptoms in patients with mild COVID-19. Result of the multicenter, double- blinded, randomized controlled trial (PLATEAU study)
  13. 832673
    “…While high interleukin (IL)-6 and C-reactive protein are associated with more severe disease, it is unclear whether other cytokines are associated with PCC. …”
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    401. Risk of Post-COVID Conditions Correlates with IL-6 Plasma Levels and Is Reduced by Early Antibody Therapy
  14. 832674
    “…[Figure: see text] [Figure: see text] CONCLUSION: Sotrovimab-treated patients had reduced viral load by D7 which further decreased through D28, despite being IC and infected with Omicron subvariants (reduced in vitro neutralization has been reported for some of the subvariants). Few severe clinical outcomes were reported (all unrelated to COVID-19). …”
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    512. Interim Results of a Prospective Cohort Study to Monitor the Emergence of Resistance in Immunocompromised Non-Hospitalized Patients With COVID-19 Who Were Treated with Sotrovimab in Great Britain: LUNAR Study 
  15. 832675
    “…BACKGROUND: Respiratory syncytial virus (RSV) can cause severe disease in older adults (≥65 years) or those with comorbidities. …”
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    2634. All-Cause Hospitalization Following Outpatient Episodes for RSV Among Adults in the United States using an Integrated EHR-Claims Data Source
  16. 832676
    “…While vaccination blunted severe outcomes, breakthrough infections may arise from lower vaccine-induced antibody quality. …”
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    2373. "Longitudinal Investigation of Avidity Maturation following Multiple Doses of BNT162b2 mRNA Vaccine Including Bivalent Boosters among Nursing Home Residents and Healthcare Workers"
  17. 832677
    “…BACKGROUND: Respiratory syncytial virus (RSV) is ubiquitous and infects almost all children during the first two years of life; infants (<1 year) and children with high-risk conditions (preterm, congenital heart disease, chronic lung disease, immunocompromised) are at an increased risk for severe infection and hospitalization. Most patients are managed at home, yet data are sparse on the natural history of RSV infection in non-hospitalized populations. …”
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    2627. Natural History of RSV Infection in Outpatient Episodes Among Children in the United States using Two EHR Data Sources by COVID-19 Era
  18. 832678
    “…The two subgroups were similar in baseline comorbidities, severity measures, and sources of bacteremia (Table 1). …”
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    2789. Cefepime Versus Non-Cefepime/Non-Carbapenem Therapy for Blood Stream Infections Caused by Non-ESBL-Producing Serratia Marcescens: A Subgroup Analysis of The Carbapenem-Serratia Multicenter Retrospective Cohort Study
  19. 832679
    “…Participants were primarily male (63.0%) or white (57.3%) (Table 1) and severe acute COVID-19 was infrequent (9.6% hospitalized). …”
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    437. Does “Long COVID” Resolve by One Year in U.S. Military Health System Beneficiaries?
  20. 832680
    “…No significant differences were observed in baseline characteristics, bacteremia sources or severity; however, CBCT patients had longer definitive therapy and more prolonged hospital stay (Table 1). …”
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    2787. Carbapenem Versus Non-Carbapenem Based Therapy for Blood Stream Infection Caused by Serratia Marcescens: A Multicenter Retrospective Cohort Study
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