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832901por Cui, LiHuang, Xiang, ShouYang, Chen, DeChun, Fu, Rui, Zhang, Xin, Chen, JingTao, Wang, XinTao“…BACKGROUND: Autogenous bone graft is the gold standard bone grafting substrate available in spinal fusion because of its osteoconductive, osteogenic, and osteoinductive properties. However, several shortcomings including bleeding, infection, chronic pain, and nerve injury are known to be associated with the procedure. …”
Publicado 2020
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832902por Peterson, James, Drazan, Daniel, Czajka, Hanna, Maguire, Jason, Pregaldien, Jean-Louis, Seppa, Ilkka, Maansson, Roger, O’Neill, Robert, Anderson, Annaliesa S, Balmer, Paul, Beeslaar, Johannes, Perez, John L“…Local reactions and systemic events after MenABCWY or MenB-FHbp were similarly frequent, mostly mild/moderate in severity (Figure 2), and unaffected by MenACWY experience. …”
Publicado 2020
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832903por Simon, Jakub, Kennedy, Stephen, Mahon, Barbara, Dubey, Sheri, Grant-Klein, Rebecca, Liu, Ken, Hartzel, Jonathan, Coller, Beth-Ann, Welebob, Carolee, Hanson, Mary, Grais, Rebecca“…ERVEBO®, a live recombinant vesicular stomatitis virus (VSV) vaccine containing the Zaire ebolavirus glycoprotein (GP) in place of the VSV GP (rVSVΔG-ZEBOV-GP), was developed by Merck & Co., Inc., Kenilworth, NJ, USA in collaboration with multiple partners to prevent EVD and has been approved for human use in several countries. METHODS: We pooled data from three Phase 2/3 clinical trials conducted in Guinea (FLW), Sierra Leone (STRIVE), and Liberia (PREVAIL) during the 2013–2016 West African outbreak to assess immune responses using a validated assay in each of the three studies and performed a post hoc analysis by sex, age (18–50 yrs & >50 yrs) and baseline (BL) GP-enzyme-linked immunosorbent assay (ELISA) titer (< 200 & ≥200 EU/ml). …”
Publicado 2020
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832904por Criner, Gerard J, Criner, Gerard J, Ahn, Mi Young, Huhn, Gregory, Subramanian, Aruna, Lumbreras, Carlos, Schmiedel, Stefan, Hyland, Robert H, Suri, Vithika, Cao, Huyen, Wang, Hongyuan, SenGupta, Devi, Chokkalingam, Anand, Osinusi, Anu, Brainard, Diana M, Chen, Yao-Shen, Chen, Yao-Shen, Günthard, Huldrych, Sanz-Moreno, D Jose, Aberg, Judith A, Nicastri, Emanuele, Tsang, Owen Tak-Yin, Tsang, Owen Tak-Yin“…BACKGROUND: Remdesivir (RDV) has been shown to shorten recovery time and was well tolerated in patients with severe COVID-19. Here we report safety of RDV in patients with moderate COVID-19. …”
Publicado 2020
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832905por Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Ali, Asad, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Chittaganpitch, Malinee, Echavarria, Marcela, Fasce, Rodrigo A, Goswami, Doli, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mira-Iglesias, Ainara, Moore, David P, Moraleda, Cinta, Nunes, Marta, Oshitani, Histoshi, Owor, Betty E, Polack, Fernando P, O'Brien, Katherine L, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Scott, J Anthony G, Simões, Eric A F, Strand, Tor A, Thea, Donald M, Treurnicht, Florette K, Vaccari, Linda C, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, Nair, Harish“…INTERPRETATION: Infants younger than 1 year have disproportionately high risks of severe human metapneumovirus infections across all World Bank income regions and all child mortality settings, similar to respiratory syncytial virus and influenza virus. …”
Publicado 2020
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832906“…The differentially expressed mRNAs and lncRNAs were associated with the regulation of cell apoptosis, proliferation, and cell cycle. Meanwhile, several signaling pathways involved in these processes, including the mTOR signaling pathway, Ras signaling pathway, HIF-1 signaling pathway, NF-kappa B signaling pathway, and TGF-beta signaling pathway, also were identified through the interaction net in the significant pathways (Path-Net) analysis. …”
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832907por Rahayu, Endang Sutriswati, Mariyatun, Mariyatun, Putri Manurung, Nancy Eka, Hasan, Pratama Nur, Therdtatha, Phatthanaphong, Mishima, Riko, Komalasari, Husnita, Mahfuzah, Nurul Ain, Pamungkaningtyas, Fathyah Hanum, Yoga, Wahyu Krisna, Nurfiana, Dina Aulia, Liwan, Stefanie Yolanda, Juffrie, Mohammad, Nugroho, Agung Endro, Utami, Tyas“…During the ingestion period (from day 11 to day 101), several parameters to measure and analyze the results included body weight and height (once a month), the lipid profile, GM analysis using MiSeq, short-chain fatty acid (SCFA) analysis using gas chromatography, and the measurement of fecal pH using a pH meter. …”
Publicado 2021
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832908por Macedo, Etienne, Hemmila, Ulla, Sharma, Sanjib Kumar, Claure-Del Granado, Rolando, Mzinganjira, Henry, Burdmann, Emmanuel A., Cerdá, Jorge, Feehally, John, Finkelstein, Fredric, García-García, Guillermo, Jha, Vivekanand, Lameire, Norbert H., Lee, Euyhyun, Levin, Nathan W., Lewington, Andrew, Lombardi, Raúl, Rocco, Michael V., Aronoff-Spencer, Eliah, Tonelli, Marcello, Yeates, Karen, Remuzzi, Giuseppe, Mehta, Ravindra L.“…In the intervention phase, more patients received fluids (observation 714/978 [73%] versus intervention 874/1,123 [78%]; 95% CI 0.63, 0.94; p = 0.012), hospitalization was reduced (observation 578/978 [59%] versus intervention 548/1,123 [49%]; 95% CI 0.55, 0.79; p < 0.001), and admitted patients with severe AKI did not show a significantly lower mortality during follow-up (observation 27/135 [20%] versus intervention 21/178 [11.8%]; 95% CI 0.98, 3.52; p = 0.057). …”
Publicado 2021
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832909por Richez, Christophe, Flipo, René-Marc, Berenbaum, Francis, Cantagrel, Alain, Claudepierre, Pascal, Debiais, Françoise, Dieudé, Philippe, Goupille, Philippe, Roux, Christian, Schaeverbeke, Thierry, Wendling, Daniel, Pham, Thao, Thomas, Thierry“…Quelques indices suggèrent que les personnes prenant une dose immunosuppressive de corticoïdes présentent un risque accru de développer une forme sévère de COVID-19. Les infiltrations intra-articulaires de glucocorticoïdes sont autorisées lorsqu’il n’existe pas d’alternative thérapeutique raisonnable et sous réserve de précautions protégeant le patient et le praticien d’une contamination virale, ce qui inclut une information appropriée du patient. …”
Publicado 2021
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832910“…Unmet contraceptive needs are the main cause of short inter-pregnancy intervals, early childbearing, physical abuse, unintended pregnancy, poor maternal and child health outcomes. Several studies have documented low contraceptives use among female sex workers (FSWs), but research has paid limited attention to understanding factors associated with unmet contraceptive needs among this population in semi urban Blantyre Malawi. …”
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832911por Li, Fang, Li, Yuan-Yuan, Liu, Ming-Jin, Fang, Li-Qun, Dean, Natalie E, Wong, Gary W K, Yang, Xiao-Bing, Longini, Ira, Halloran, M Elizabeth, Wang, Huai-Ji, Liu, Pu-Lin, Pang, Yan-Hui, Yan, Ya-Qiong, Liu, Su, Xia, Wei, Lu, Xiao-Xia, Liu, Qi, Yang, Yang, Xu, Shun-Qing“…We aimed to assess household transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and risk factors associated with infectivity and susceptibility to infection in Wuhan. …”
Publicado 2021
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832912por Hashemian, Seyed-Mohammad Reza, Aliannejad, Rasoul, Zarrabi, Morteza, Soleimani, Masoud, Vosough, Massoud, Hosseini, Seyedeh-Esmat, Hossieni, Hamed, Keshel, Saeid Heidari, Naderpour, Zeinab, Hajizadeh-Saffar, Ensiyeh, Shajareh, Elham, Jamaati, Hamidreza, Soufi-Zomorrod, Mina, Khavandgar, Naghmeh, Alemi, Hediyeh, Karimi, Aliasghar, Pak, Neda, Rouzbahani, Negin Hossieni, Nouri, Masoumeh, Sorouri, Majid, Kashani, Ladan, Madani, Hoda, Aghdami, Nasser, Vasei, Mohammad, Baharvand, Hossein“…The patients were critically ill with severe hypoxemia and required mechanical ventilation. …”
Publicado 2021
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832913por Adler, Ubiratan Cardinalli, Adler, Maristela Schiabel, Hotta, Livia Mitchiguian, Padula, Ana Elisa Madureira, de Toledo Cesar, Amarilys, Diniz, José Nelson Martins, Mestre, Crislaine Aparecida Antonio, Spiller, Katia Regina, Soares, Lidiamara, de Freitas Santos, Helen, Martinez, Edson Zangiacomi“…Exclusion criterium: severe acute respiratory syndrome. INTERVENTION AND COMPARATOR: Homeopathy: 1 globule of Natrum muriaticum LM2 diluted in 20 mL of alcohol 30% and dispensed in a 30 ml bottle. …”
Publicado 2021
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832914por Elmonir, Walid, Shalaan, Samar, Tahoun, Amin, Mahmoud, Samy F., Remela, Etab M. Abo, Eissa, Radwa, El-Sharkawy, Hanem, Shukry, Mustafa, Zahran, Rasha N.“…Shiga toxin-producing Escherichia coli (STEC) is a pathotype of E. coli that causes enteric and systemic diseases ranging from diarrhoea to severe hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). …”
Publicado 2021
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832915por Plaza-Rodríguez, Carolina, Alt, Katja, Grobbel, Mirjam, Hammerl, Jens Andre, Irrgang, Alexandra, Szabo, Istvan, Stingl, Kerstin, Schuh, Elisabeth, Wiehle, Lars, Pfefferkorn, Beatrice, Naumann, Steffen, Kaesbohrer, Annemarie, Tenhagen, Bernd-Alois“…The aim of this study was to investigate the occurrence and the antibiotic resistance patterns of several bacterial species in certain wild animals in Germany, including wild boars (Sus scrofa), roe deer (Capreolus capreolus) and wild ducks (family Anatidae, subfamily Anatinae) and geese (family Anatidae, subfamily Anserinae). …”
Publicado 2021
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832916“…Overall, these values correlated well with the clinical evaluation of involved joints. (18)F–FDG PET imaging data provided a distribution of joint involvement with varying degrees of severity and phase of disease activity (moderate, low, and remission) in the same patient. …”
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832917por Chen, Ling-Wei, Aubert, Adrien M., Shivappa, Nitin, Bernard, Jonathan Y., Mensink-Bout, Sara M., Geraghty, Aisling A., Mehegan, John, Suderman, Matthew, Polanska, Kinga, Hanke, Wojciech, Jankowska, Agnieszka, Relton, Caroline L., Crozier, Sarah R., Harvey, Nicholas C., Cooper, Cyrus, Hanson, Mark, Godfrey, Keith M., Gaillard, Romy, Duijts, Liesbeth, Heude, Barbara, Hébert, James R., McAuliffe, Fionnuala M., Kelleher, Cecily C., Phillips, Catherine M.“…These associations were robust in several sensitivity analyses and further adjustment for birth weight and childhood diet did not meaningfully alter the associations and conclusions. …”
Publicado 2021
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832918por Giza, Christopher C., McCrea, Michael, Huber, Daniel, Cameron, Kenneth L., Houston, Megan N., Jackson, Jonathan C., McGinty, Gerald, Pasquina, Paul, Broglio, Steven P., Brooks, Alison, DiFiori, John, Duma, Stefan, Harezlak, Jaroslaw, Goldman, Joshua, Guskiewicz, Kevin, McAllister, Thomas W., McArthur, David, Meier, Timothy B., Mihalik, Jason P., Nelson, Lindsay D., Rowson, Steven, Gill, Jessica, Foroud, Tatiana, Katz, Barry, Saykin, Andrew, Campbell, Darren E., Svoboda, Steven“…Clinical measures included the Sport Concussion Assessment Tool–Third Edition symptom severity evaluation, the Standardized Assessment of Concussion, the Balance Error Scoring System, and the 18-item Brief Symptom Inventory. …”
Publicado 2021
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832919por Richmond, Peter, Hatchuel, Lara, Dong, Min, Ma, Brenda, Hu, Branda, Smolenov, Igor, Li, Ping, Liang, Peng, Han, Htay Htay, Liang, Joshua, Clemens, Ralf“…BACKGROUND: As part of the accelerated development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we report a dose-finding and adjuvant justification study of SCB-2019, a protein subunit vaccine candidate containing a stabilised trimeric form of the spike (S)-protein (S-Trimer) combined with two different adjuvants. …”
Publicado 2021
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832920por Cavalli, Giulio, Larcher, Alessandro, Tomelleri, Alessandro, Campochiaro, Corrado, Della-Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Boffini, Nicola, Ruggeri, Annalisa, Poli, Andrea, Scarpellini, Paolo, Rovere-Querini, Patrizia, Tresoldi, Moreno, Salonia, Andrea, Montorsi, Francesco, Landoni, Giovanni, Castagna, Antonella, Ciceri, Fabio, Zangrillo, Alberto, Dagna, Lorenzo“…BACKGROUND: Patients with severe COVID-19 develop a life-threatening hyperinflammatory response to the virus. …”
Publicado 2021
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