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833141por Peerani, Farhad, Watt, Makayla, Ismond, Kathleen P, Whitlock, Reid, Ambrosio, Lindsy, Hotte, Naomi, Mitchell, Nicholas, Bailey, Robert J, Kroeker, Karen, Dieleman, Levinus A, Siffledeen, Jesse, Lim, Allen, Wong, Karen, Halloran, Brendan P, Baumgart, Daniel C, Taylor, Lorian, Raman, Maitreyi, Madsen, Karen L, Tandon, Puneeta“…No changes were seen in IBD severity or in blood markers of inflammation. In conclusion, this study demonstrates evidence that a 12-week online stress reduction intervention had low dropout rates, high adherence and beneficial effects on stress, mental health, and quality of life measures. …”
Publicado 2022
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833142“…Most TEAEs were mild; only seven patients experienced a moderate TEAE, and no severe or serious TEAEs occurred. In the multiple-dose phase, participants whose doses were titrated from TPIP 112.5 µg QD to 225 µg QD experienced fewer TEAEs than those who received 225 µg QD at treatment initiation (66.7% vs 100.0%), and all TEAEs with dose titration were mild. …”
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833143por Hubacher, David, Byamugisha, Josaphat, Kakaire, Othman, Nalubwama, Hadija, Emtell Iwarsson, Karin, Bratlie, Marte, Chen, Pai-Lien, Gemzell-Danielsson, Kristina“…For primary safety endpoints, we examined removal complications and grouped them according to severity. For secondary endpoints on efficacy, we defined three device outcomes: intact implant removed without additional tools (primary), implant removed allowing implant breakage, but without tools (secondary) and implant removed allowing implant breakage and non-scalpel tools (tertiary). …”
Publicado 2022
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833144por Lyall, Matthew, Crawford, Rebecca, Bell, Timothy, Mamolo, Carla, Neuhof, Alexander, Levy, Courtney, Heyes, Anne“…Caregivers can struggle to balance care responsibilities and jobs, and their HRQOL is affected in several areas, including emotional-, role-, social-, and work-related aspects of life. …”
Publicado 2022
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833145por Mathiasen, Kim, Andersen, Tonny E, Lichtenstein, Mia Beck, Ehlers, Lars Holger, Riper, Heleen, Kleiboer, Annet, Roessler, Kirsten K“…The primary outcome was change in depression severity on the 9-item Patient Health Questionnaire (PHQ-9). …”
Publicado 2022
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833146por Frustaci, Anna Maria, Del Poeta, Giovanni, Visentin, Andrea, Sportoletti, Paolo, Fresa, Alberto, Vitale, Candida, Murru, Roberta, Chiarenza, Annalisa, Sanna, Alessandro, Mauro, Francesca Romana, Reda, Gianluigi, Gentile, Massimo, Varettoni, Marzia, Baratè, Claudia, Borella, Chiara, Greco, Antonino, Deodato, Marina, Zamprogna, Giulia, Laureana, Roberta, Cipiciani, Alessandra, Galitzia, Andrea, Curto Pelle, Angelo, Morelli, Francesca, Malvisi, Lucio, Coscia, Marta, Laurenti, Luca, Trentin, Livio, Montillo, Marco, Cairoli, Roberto, Tedeschi, Alessandra“…METHODS: Impact of age, presence of Cumulative Illness Rating Scale (CIRS) >6 or severe organ impairment (CIRS3+), Eastern Cooperative Oncology Group–Performance Status (ECOG-PS), renal function, and concomitant medications were retrospectively analyzed on treatment management (definitive discontinuation due to toxicity, discontinuation due to toxicity, Tox-DTD; permanent dose reduction, PDR) and survival [progression free survival (PFS), event free survival (EFS), overall survival (OS)] in unselected patients receiving venetoclax monotherapy in common practice. …”
Publicado 2022
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833147“…In addition, immune checkpoint blockage markedly increases A2aR expression in T cells, which could dampen their anti-tumor response. Several A2aR antagonists are under clinical development, but with limited clinical benefit reported so far. …”
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833148por Lone, Kouser Sideeq, Khan, S. Muhammad Salim, Qurieshi, Mariya Amin, Majid, Sabhiya, Pandit, Mohammad Iqbal, Haq, Inaamul, Ahmad, Javid, Bhat, Ashfaq Ahmad, Bashir, Khalid, Bilquees, Sufoora, Fazili, Anjum Bashir, Hassan, Muzamil, Jan, Yasmeen, Kaul, Rauf-ur Rashid, Khan, Zahid Ali, Mushtaq, Beenish, Nazir, Fouzia, Qureshi, Uruj Altaf, Raja, Malik Waseem, Rasool, Mahbooba, Asma, Anjum, Bhat, Arif Akbar, Chowdri, Iqra Nisar, Ismail, Shaista, Jeelani, Asif, Kawoosa, Misbah Ferooz, Khan, Mehvish Afzal, Khan, Mosin Saleem, Kousar, Rafiya, Lone, Ab Aziz, Nabi, Shahroz, Qazi, Tanzeela Bashir, Rather, Rouf Hussain, Sabah, Iram, Sumji, Ishtiyaq Ahmad“…Despite a comparatively lower number of cases reported and lower vaccination coverage in the region, our study found such high seropositivity across all age groups, which indicates the higher number of subclinical and less severe unnoticed caseload in the community.…”
Publicado 2022
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833149por Wang, Yong-Jun, Li, Zi-Xiao, Gu, Hong-Qiu, Zhai, Yi, Zhou, Qi, Jiang, Yong, Zhao, Xing-Quan, Wang, Yi-Long, Yang, Xin, Wang, Chun-Juan, Meng, Xia, Li, Hao, Liu, Li-Ping, Jing, Jing, Wu, Jing, Xu, An-Ding, Dong, Qiang, Wang, David, Wang, Wen-Zhi, Ma, Xu-Dong, Zhao, Ji-Zong“…Furthermore, stroke is also the leading cause of disability-adjusted life-year (DALY) in China, the number of DALYs reached 45.9 million in 2019. Several recent large-scale epidemiological surveys have updated the data on pre-existing conditions contributed to stroke. …”
Publicado 2022
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833150por Grasselli, Giacomo, Zanella, Alberto, Carlesso, Eleonora, Florio, Gaetano, Canakoglu, Arif, Bellani, Giacomo, Bottino, Nicola, Cabrini, Luca, Castelli, Gian Paolo, Catena, Emanuele, Cecconi, Maurizio, Cereda, Danilo, Chiumello, Davide, Forastieri, Andrea, Foti, Giuseppe, Gemma, Marco, Giudici, Riccardo, Grazioli, Lorenzo, Lombardo, Andrea, Lorini, Ferdinando Luca, Madotto, Fabiana, Mantovani, Alberto, Mistraletti, Giovanni, Mojoli, Francesco, Mongodi, Silvia, Monti, Gianpaola, Muttini, Stefano, Piva, Simone, Protti, Alessandro, Rasulo, Frank, Scandroglio, Anna Mara, Severgnini, Paolo, Storti, Enrico, Fumagalli, Roberto, Pesenti, Antonio“…These findings suggest a substantial reduction of the risk of developing COVID-19–related severe acute respiratory failure requiring ICU admission among vaccinated people.…”
Publicado 2022
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833151por Rizik, David G., Rajagopal, Vivek, Makkar, Raj R., Bajwa, Tanvir, Kleiman, Neal S., Linke, Axel, Kereiakes, Dean J., Waksman, Ron, Thourani, Vinod H., Stoler, Robert C., Mishkel, Gregory J., Iyer, Vijay S., Buchbinder, Maurice, Götberg, Matthias, Bjursten, Henrik, Allocco, Dominic J., Reardon, Michael J.“…Patients had high risk for aortic stenosis or severe or symptomatic aortic stenosis. Data were analyzed from September 22, 2014, to May 21, 2021. …”
Publicado 2022
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833152por Lei, Haiyan, Liu, Jun, Wang, Wei, Yang, Xinyi, Feng, Zhouqin, Zang, Pu, Lu, Bin, Shao, Jiaqing“…BACKGROUND: Several recent studies have found that Osteocalcin (OCN), a multifunctional protein secreted exclusively by osteoblasts, is beneficial to glucose metabolism and type 2 diabetes mellitus (T2DM). …”
Publicado 2022
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833153“…DXA= osteopenia in AP spine and severe osteoporosis in other areas: femur neck left T-Score of -3.1. …”
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833154por Cara, Jose, Carlsson, Martin, Rosenfeld, Ron G, Wajnrajch, Michael P, Wang, Ronnie, Zadik, Zvi“…The Year 1 mean HV reported by Ranke and Lindberg for children with a chronological average-centered age of 7.5 years was 9.4 cm/year and 8.3 cm/year for children with severe and moderate GHD, respectively. The Year 1 mean HV reported by Bakker et al for children with idiopathic GHD aged 7.5 years at the beginning of hGH therapy was ∼10 cm/year (for males and females). …”
Publicado 2022
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833155por Biller, Beverly M K, Fleseriu, Maria, Pivonello, Rosario, Feelders, Richard A, Lacroix, Andre, Auchus, Richard J, Piacentini, Andrea, Pedroncelli, Alberto M, Newell-Price, John“…Cardiovascular/metabolic-related parameters, physical features (rating: 0=absent;1=mild;2=moderate;3=severe), CushingQoL and Beck Depression Inventory-II (BDI-II) scores were also evaluated. …”
Publicado 2022
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833156por Trukhina, Diana, Mamedova, Elizaveta, Nikitin, Alexey, Koshkin, Philipp, Belaya, Zhanna, Melnichenko, Galina“…In addition, we found decreased microRNAs with oncogene potential: miR-3182 (padj=0.007), hsa-miR-875-5p (padj<0.001), hsa-miR-6749-5p (padj<0.001). 173 microRNA differed in phMEN1 and control groups (11 microRNAs upregulated, 162 — downregulated). We detected several decreased microRNAs in phMEN1 that participate in tumor genesis: hsa-miR-625-3p (padj<0.005), hsa-miR-3168 (padj=0,028), hsa-miR-302b-3p (padj<0.001). …”
Publicado 2022
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833157por Assié, Guillaume, Bertherat, Jérôme, Bonnet-Serrano, Fidéline, Borson-Chazot, Françoise, Bricaire, Léopoldine, Cavalcante, Isadora P, Chevalier, Nicolas, Christin-Maitre, Sophie, Espiard, Stéphanie, Fassnacht, Martin, Groussin, Lionel, Guignat, Laurence, Haissaguerre, Magalie, Jouinot, Anne, Jublanc, Christel, Kamenicky, Peter, Kroiss, Matthias, Lefebvre, Hervé, Libé, Rossella, Maione, Luigi, North, Marie-Odile, Pasmant, Eric, Perlemoine, Karine, Raffin-Sanson, Marie-Laure, Ragazzon, Bruno, Raverot, Gérald, Reincke, Martin, Tabarin, Antoine, Touraine, Philippe, Vaczlavik, Anna, Vaduva, Patricia, Vantyghem, Marie-Christine, Vatier, Camille, Bouys, Lucas“…CONCLUSION: We report the largest series of index case patients investigated for ARMC5 with clinical characterization and confirm that ARMC5 pathogenic variants are associated with a more severe phenotype. In order to minimize negative ARMC5 screening, genotyping could be limited to clear bilateral adrenal involvement on imaging and autonomous cortisol secretion, with an optimum yield for routine clinical practice. …”
Publicado 2022
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833158por Welch, Lurah, Malpani, Ashish, Plummer, Daniel, Churilla, James, Benson, Matthew, Carakushansky, Mauri, Hossain, Jobayer, Mauras, Nelly“…CONCLUSION: There are significant differences in FFM and skeletal muscle strength and endurance in prepubertal boys with severe short stature compared to healthy age-matched controls. …”
Publicado 2022
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833159por Auchus, Richard J, Bay, Camden P, Honzel, Brooke, Luther, James M, Peng, Dungeng, Vaidya, Anand, Yozamp, Nicholas, Brown, Jenifer M“…In order to characterize parameters across the severity spectrum of non-suppressible and renin-independent aldosterone production, participants with suppressed renin activity were categorized by tertile of 24h urinary aldosterone production following oral sodium suppression testing. …”
Publicado 2022
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833160por Hui, Lisa, Marzan, Melvin B., Rolnik, Daniel L., Potenza, Stephanie, Pritchard, Natasha, Said, Joanne M., Palmer, Kirsten R., Whitehead, Clare L., Sheehan, Penelope M., Ford, Jolyon, Mol, Ben W., Walker, Susan P.“…BACKGROUND: COVID-19 infection in pregnancy is associated with a higher risk of progression to severe disease, but vaccine uptake by pregnant women is hindered by persistent safety concerns. …”
Publicado 2023
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