“…We performed simulation studies to compare the power of several methods such as KM-UMMDR, Cox-UMMDR, Cox2-UMMDR, Cox-MDR, and KM-MDR by considering the effect of covariates and the marginal effect of SNPs. …”
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“…INTRODUCTION: Coronavirus disease 2019 (COVID-19) is due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significant morbidity and mortality that is well documented. …”
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“…Future research could also examine experiences of MD-PhD students from groups underrepresented in medicine and the biomedical-research workforce (e.g., first-generation college graduates, women, and racial/ethnic minorities), which might serve to inform interventions to increase the numbers of applicants to MD-PhD programs and help reverse the steady decline in the physician-scientist workforce over the past several decades.…”
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“…Overall, patients with migraine also cared for in neurology practices used more of all health care resource types under consideration and had more medical issues, which may be due in some part to a more severe, frequent and disabling disease state compared to those who sought care exclusively from PC practices.…”
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“…Les patients atteints d’un cancer actif présentent un risque accru de forme sévère de COVID-19 et devraient être par conséquence une population cible pour la vaccination. …”
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“…Les patients traités pour un cancer apparaissent d’autant plus à risque de SSPT qu’ils doivent faire face à la fois à leur pathologie grave et à la peur de développer une forme sévère de COVID-19 dans un contexte social peu favorable pour les soutenir. …”
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“…Most adverse reactions were mild and moderate in severity. Injection site pain was the most frequently reported event (73 [13%] of 550 participants), occurring in 36 (16%) of 219 participants in the 1·5 μg group, 35 (16%) of 217 in the 3·0 μg group, and two (2%) in the alum-only group. …”
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“…All positive (PCR confirmed) COVID-19 patients ≤65 years old who have Hb≤9 and at least one of the severe COVID-19 symptoms (tachypnea (breathing rate> 30 beats per minute), hypoxemia (O2 ≤93 saturation, the partial pressure ratio of arterial oxygen <300), Lung infiltration (> 50% of lung field within 24 to 48 hours), progressive lymphopenia, LDH>245 U/I, CRP>100) and are willing to cooperate in this project will be included in the study. …”
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“…In addition, the incidence of obesity in offspring was lower than that reported in studies based on measured or self-reported weight and height and may include mainly moderate and severe obesity cases who needed and/or actively sought medical care. …”
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“…Accrual of multimorbidity was also more strongly associated with risk of infection death (five or more comorbidities vs none: 9·53, 6·97–13·03) than of non-infection death (5·26, 4·84–5·72). INTERPRETATION: Several NCDs are associated with an increased risk of infection death, suggesting that some of the reported associations with COVID-19 mortality might be non-specific. …”
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“…One patient had facial and neck swelling 2 days after administration of SC daratumumab (with no other symptoms) but resolved within 24 hours of an additional dose of dexamethasone and did not recur upon re-challenge of SC daratumumab. Severe neutropenia (ANC less than 500) was reported in 9% of patients (2/22), both patients in the group naïve to daratumumab. …”
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“…Surface testing for viral RNA in the outpatient infusions suites included spaces where several patients with recent SARS-CoV-2 infection were receiving cancer treatment in the outpatient setting. …”
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“…Thus, myelo- and lympho-suppression caused by cancer itself as well as cytotoxic treatment may pose a challenge to COVID-19 patients with solid and hematological tumors, but severe events from initial onset of COVID-19 appear to be more frequent in blood malignancies vs other cancer types. …”
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“…It has been proposed that patients with hematologic malignancy and autoimmune diseases receiving anti-CD20 monoclonal antibody (mAb) therapy are particularly at risk of severe Coronavirus disease (COVID-19) because the profound and long-lasting B-cell depletion induced by anti-CD20 mAb may impair virus clearance and may also contribute to reactivation of latent viruses, especially hepatitis B and JC viruses. …”
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“…We used univariate logistic regression models (adjusted for age, BMI, and sex) to analyse the associations between risk factors and post-vaccination infection, and the associations of individual symptoms, overall disease duration, and disease severity with vaccination status. FINDINGS: Between Dec 8, 2020, and July 4, 2021, 1 240 009 COVID Symptom Study app users reported a first vaccine dose, of whom 6030 (0·5%) subsequently tested positive for SARS-CoV-2 (cases 1), and 971 504 reported a second dose, of whom 2370 (0·2%) subsequently tested positive for SARS-CoV-2 (cases 2). …”
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“…In both groups, factors associated with the greatest hyperglycemic crisis risk were low income (≥$200 000 vs <$40 000: type 1 diabetes incidence risk ratio [IRR], 0.61 [95% CI, 0.46-0.81]; type 2 diabetes IRR, 0.69 [95% CI, 0.56-0.86]), Black race/ethnicity (vs White race/ethnicity: type 1 diabetes IRR, 1.33 [95% CI, 1.01-1.74]; type 2 diabetes IRR, 1.18 [95% CI, 1.09-1.27]), high hemoglobin A(1c) level (≥10% vs 6.5%-6.9%: type 1 diabetes IRR, 7.81 [95% CI, 5.78-10.54]; type 2 diabetes IRR, 7.06 [95% CI, 6.26-7.96]), history of hyperglycemic crises (type 1 diabetes IRR, 7.88 [95% CI, 6.06-9.99]; type 2 diabetes IRR, 17.51 [95% CI, 15.07-20.34]), severe hypoglycemia (type 1 diabetes IRR, 2.77 [95% CI, 2.15-3.56]; type 2 diabetes IRR, 4.18 [95% CI, 3.58-4.87]), depression (type 1 diabetes IRR, 1.62 [95% CI, 1.37-1.92]; type 2 diabetes IRR, 1.46 [95% CI, 1.34-1.59]), neuropathy (type 1 diabetes IRR, 1.64 [95% CI, 1.39-1.93]; type 2 diabetes IRR, 1.25 [95% CI, 1.17-1.34]), and nephropathy (type 1 diabetes IRR, 1.22 [95% CI, 1.01-1.48]; type 2 diabetes IRR, 1.23 [95% CI, 1.14-1.33]). …”
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“…The primary outcome was depression severity (measured using the Patient Health Questionnaire 9 (PHQ-9)). …”
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“…Les séquelles respiratoires et post-traumatiques pourraient être plus sévères chez les patients ayant nécessité respectivement une oxygénothérapie et de la réanimation. …”
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“…RÉSULTATS: Les répondants étaient âgés de 62 ans en moyenne, majoritairement des femmes (86 %). 947 patients ont répondu aux questions portant sur leurs craintes au cours du 1(er) confinement : 61,4 % (n = 681) se sont sentis plus inquiets que d’habitude, 50,1 % (n = 474) plus stressés, 47,1 % (n = 446) plus tristes et 39,5 % (n = 374) plus seuls. 80,3 % (n = 760) ont eu peur d’être contaminés par la Covid-19, de faire une forme sévère ou de mourir et 40,1 % (n = 380) ont eu peur de ne plus pouvoir se soigner pour leur maladie. 60,6 % des répondants (n = 620/1024) ont eu des craintes liées à leur traitement en lien avec la Covid-19 et, parmi eux, 8,4 % (n = 52/620) ont décidé de le stopper temporairement. 929 patients ont répondu aux questions portant sur les conséquences liées à la pandémie : 41,9 % (n = 389) des malades avaient pris du poids, 39,1 % (n = 365) avaient constaté une augmentation de la fréquence et/ou de l’intensité de leurs poussées, 24,4 % (n = 227) avaient augmenté leur consommation d’antidouleurs ou d’anti-inflammatoires et 17,9 % (n = 166) leur consommation de thé ou café. 911 patients ont répondu aux questions portant sur la recherche d’information sur la Covid-19 en lien avec leur PR : 60,9 % (n = 555) s’étaient tournés vers leur rhumatologue, 52,1 % (n = 475) leur médecin généraliste, 48 % (n = 438) les associations de malades, 40,3 % (n = 367) les sites des organismes officiels, 22,6 % (n = 205) les médias et 3,5 % (n = 32) les réseaux sociaux. …”
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“…INTRODUCTION: Près de 10 % des patients ayant présenté une COVID-19 rapportent des symptômes persistants plus de 12 semaines après l’infection initiale, y compris lorsque celle-ci était non sévère. Même si l’origine et le traitement du COVID-long restent inconnus, des données préliminaires non publiées suggèrent un effet positif de la vaccination [1]. …”
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