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  1. 1021
    “…Objectives: This paper will demonstrate the use of machine learning to explore the relationship between functional limitation and symptom severity to PAD severity. Methods: We performed supervised machine learning and graphical analysis, analyzing 703 patients from an administrative database with data comprising the toe–brachial index (TBI), baseline demographics and symptom score(s) derived from a modified vascular quality-of-life questionnaire, calf circumference in centimeters and a six-minute walk (distance in meters). …”
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    Machine Learning Confirms Nonlinear Relationship between Severity of Peripheral Arterial Disease, Functional Limitation and Symptom Severity
  2. 1022
    por Canonica, Giorgio Walter, Blasi, Francesco, Paggiaro, Pierluigi, Senna, Gianenrico, Passalacqua, Giovanni, Spanevello, Antonio, Aliberti, Stefano, Bagnasco, Diego, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Bucca, Caterina, Caiaffa, Maria F., Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Carpagnano, Giovanna E., Caruso, Cristiano, Centanni, Stefano, Conte, Maria E., Corsico, Angelo G., Cosmi, Lorenzo, Costantino, Maria T., Crimi, Nunzio, D’Alò, Simona, D'Amato, Maria, Del Giacco, Stefano, Farsi, Alessandro, Favero, Elisabetta, Foschino Barbaro, Maria P., Guarnieri, Gabriella, Guida, Giuseppe, Latorre, Manuela, Lo Cicero, Salvatore, Lombardi, Carlo, Macchia, Luigi, Mazza, Francesco, Menzella, Francesco, Milanese, Manlio, Montagni, Marcello, Montuschi, Paolo, Nucera, Eleonora, Parente, Roberta, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ricciardolo, Fabio L.M., Richeldi, Luca, Ridolo, Erminia, Rolla, Giovanni, Santus, Pierachille, Scichilone, Nicola, Spadaro, Giuseppe, Vianello, Andrea, Viviano, Vittorio, Yacoub, Mona R., Zappa, Maria C., Heffler, Enrico
    Publicado 2020
    “…According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. …”
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    Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)
  3. 1023
    “…The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. …”
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    CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients
  4. 1024
    “…OBJECTIVE: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity. …”
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    Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth
  5. 1025
    “…Preliminary studies show that clavicle fractures (CF) are known as an indicator in the severely injured for overall injury severity that are associated with relevant concomitant injuries in the thorax and upper extremity. …”
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    Acromioclavicular and sternoclavicular joint dislocations indicate severe concomitant thoracic and upper extremity injuries in severely injured patients
  6. 1026
    “…The severity of MR is improved in about half of patients undergoing TAVI. …”
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    Predictors of Mitral Regurgitation Severity Improvement in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation
  7. 1027
    “…We present the case of a severely immunocompromised patient with persistent replication of SARS-CoV-2, who required different courses of remdesivir. …”
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    Persistent replication of SARS-CoV-2 in a severely immunocompromised patient treated with several courses of remdesivir
  8. 1028
    “…The main aim of this study was to assess the interobserver variability between the Mayo Endoscopy Score (MES), Ulcerative Colitis Endoscopy Index of Severity (UCEIS) and Ulcerative Colitis Colonoscopy Index of Severity (UCCIS) analyzing the severity of the endoscopic lesions in patients with ulcerative colitis. …”
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    Comparison of the Mayo Endoscopy Score and the Ulcerative Colitis Endoscopy Index of Severity and the Ulcerative Colitis Colonoscopy Index of Severity
  9. 1029
    “…Laboratory data from 90 cases were analyzed, and COVID‐19 patients were classified into two groups (severe and non‐severe) based on the severity. RESULTS: Severe COVID‐19 cases on admission had higher leukocyte and neutrophil counts, neutrophil‐to‐lymphocyte ratio (NLR), D‐dimer, fibrinogen, C‐reactive protein levels, and lower lymphocyte counts compared with those of non‐severe cases (p < 0.05). …”
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    Clinical and laboratory characteristics of severe and non‐severe patients with COVID‐19: A retrospective cohort study in China
  10. 1030
    “…BACKGROUND: Severe sepsis/septic shock with severe neutropenia often leads to poor prognosis. …”
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    The clinical outcomes and biomarker features of severe sepsis/septic shock with severe neutropenia: a retrospective cohort study
  11. 1031
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    Severe hypocalcaemia and hypomagnesemia presenting with severe neurologic and gastro-intestinal symptoms: a case report and review of literature
  12. 1032
    “…BACKGROUND: The medium- and long-term effects of severe acute respiratory syndrome coronavirus 2 infection on survivors are unknown. …”
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    Medium-Term Outcomes in Severely to Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
  13. 1033
    “…Of note, this study suggested that recent history of surgery is a predictor of severity in GBS patients and is associated with the poor short-term prognosis of severe GBS.…”
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    Risk factors for the severity of Guillain-Barré syndrome and predictors of short-term prognosis of severe Guillain-Barré syndrome
  14. 1034
    “…RESEARCH QUESTION: What is the impact of treatment variability on mortality in patients with moderate to severe ARDS in the United States? STUDY DESIGN AND METHODS: We conducted a multicenter, observational cohort study of mechanically ventilated adults with ARDS and Pao(2) to Fio(2) ratio of ≤ 150 with positive end-expiratory pressure of ≥ 5 cm H(2)O, who were admitted to 29 US centers between October 1, 2016, and April 30, 2017. …”
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    Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study
  15. 1035
    “…Subjects with altered CRP, sarcopenia and severe anxiety appear more at risk of severe fatigue.…”
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    Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases
  16. 1036
    “…We report two patients previously treated with etelcalcetide who developed severe (>3.3 mmol/L) hypercalcaemia in the early post-KT course, requiring parathyroidectomy. …”
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    Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide
  17. 1037
    “…BACKGROUND: The severity of COVID-19 associates with the clinical decision making and the prognosis of COVID-19 patients, therefore, early identification of patients who are likely to develop severe or critical COVID-19 is critical in clinical practice. …”
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    Severity-associated markers and assessment model for predicting the severity of COVID-19: a retrospective study in Hangzhou, China
  18. 1038
    “…However, these modalities demand several laboratory investigations and are expensive. …”
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    Comparison of the Accuracy of Modified CT Severity Index Score and Neutrophil-to-Lymphocyte Ratio in Assessing the Severity of Acute Pancreatitis
  19. 1039
    “…BACKGROUND: Dengue fever is a common mosquito borne viral infection. Severe dengue fever associated severe hepatitis carries high mortality. …”
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    Use of intravenous N-acetylcysteine in acute severe hepatitis due to severe dengue infection: a case series
  20. 1040
    “…The mechanisms underlying the immune remodeling and severity response in coronavirus disease 2019 (COVID-19) are yet to be fully elucidated. …”
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    Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape
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