“…Les cas ont été classés en certains (PCR + ), probables (PCR− ou non faite, TDM pulmonaire évocateur) ou possibles (PCR et TDM négatifs ou non faits mais signes cliniques et/ou cas contacts). L’incidence cumulée des cas de COVID a été calculée à partir des cas certains et hospitalisés de patients MBAI suivis dans chaque service, puis comparée à celle dans la population générale sur la même période (données Santé Publique France) après standardisation indirecte sur l’âge et la région. …”
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“…Inclusion criteria: - Signed informed consent - Age 18-85 years - Evidence of pulmonary involvement on CT scan or X-ray of the chest - Duration of symptoms associated with COVID-19 ≤ 10 days - At least one of the following risk factors for progression to mechanical ventilation on the day of enrolment: 1) Arterial hypertension 2) ≥ 50 years 3) Obesity (BMI ≥ 30 kg/m2) 4) History of cardiovascular disease 5) Chronic pulmonary disease 6) Chronic renal disease 7) C-reactive protein > 35mg/L 8) Oxygen saturation at rest of ≤ 94% when breathing ambient air Exclusion criteria: - Incapacity or inability to provide informed consent - Contraindications to the class of drugs under investigation (C1 esterase inhibitor) - Treatment with tocilizumab or another IL-6R or IL-6 inhibitor before enrolment - History or suspicion of allergy to rabbits - Pregnancy or breast feeding - Active or anticipated treatment with any other complement inhibitor - Liver cirrhosis (any Child-Pugh score) - Admission to an ICU on the day or anticipated within the next 24 hours of enrolment - Invasive or non-invasive ventilation - Participation in another study with any investigational drug within the 30 days prior to enrolment - Enrolment of the study investigators, their family members, employees and other closely related or dependent persons INTERVENTION AND COMPARATOR: Patients randomized to the experimental arm will receive conestat alfa in addition to standard of care (SOC). …”
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“…PARTICIPANTS: Participants of either gender admitted to general adult wards in 21 hospital sites located in four provinces of Argentina are invited to participate in the study if they meet the following inclusion criteria and none of the exclusion criteria: Inclusion criteria: SARS-CoV-2 confirmed infection by RT-PCR; Hospital admission at least 24 hours before; Expected hospitalization in the same site ≥24 hours; Oxygen saturation ≥90% (measured by pulse oximetry) breathing ambient air; ○ Hypertension; ○ Diabetes; ○ At least moderate COPD or asthma; ○ Cardiovascular disease (history of myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting or valve replacement surgery); ○ Body mass index ≥30; Willingness to sign informed consent (online supplementary material 1 and 2). …”
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“…RANDOMISATION: The participants who meet the inclusion criteria and have signed written informed consent will be randomly allocated using a computer-generated random number to either intervention group or control group. …”
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“…The first dose of NCVs injection shall be completed within 24 hours from the time of injection to the time of enrolment; ②No redness, swelling, injury or infection of the skin or soft tissue of both ears, which is not suitable for APA; ③No history of alcohol and adhesive tape contact allergy; ④18-59 years old, regardless of gender; ⑤Those who were able to complete the questionnaire independently at the time of the first and second dose of NCVs and on the 3rd, 7th and 15th day after the first and second dose of NCVs respectively; ⑥Those who agree to participate in the trial and sign the informed consent, and can seriously abide by the precautions after the injection of NCVs and the requirements of traditional Chinese medicine auricular point plasters sticking and acupressure. …”
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“…En comparaison avec la forme classique, les patients atteints de MIS-C semblent plus âgés, avec d’avantage d’atteinte cardiaque, d’insuffisance circulatoire, de signes fonctionnels digestifs, résistent plus aux immunoglobulines et justifient davantage d’une corticothérapie [3]. …”
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“…En comparaison avec la forme classique, les patients atteints de MIS-C semblent plus âgés, avec d’avantage d’atteinte cardiaque, d’insuffisance circulatoire, de signes fonctionnels digestifs, résistent plus aux immunoglobulines et justifient davantage d’une corticothérapie [2]. …”
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“…One limitation of the event noted by attendees was that attendees were not able to sign up for the round table discussions themselves but were placed strategically at them by our Steering Committee. …”
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“…A chaque temps, la participation au GAD-7 était proche de 80 %, et montrait que 11 % des sujets présentaient des signes d'anxiété (modérée ou sévère) à 3 mois et 7 % à l'inclusion et 12 mois. …”
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“…Dans le modèle de régression logistique multivariée, les FDR de CL+ sont à J0 d'avoir un âge < à 65 ans et fait un COVID aigue peu sévère avec prise en charge en ambulatoire avec respectivement OR 2.4 (IC95 : [1.0 ; 5.4]) et OR 2.3 (IC95 : [2.3 ; 4.6]). 2) à S4 post COVID d'avoir des difficultés cognitives OR 6.046 (IC95 : [1.82 ; 20.1]) et les signes fonctionnels psychiatriques OR 5.9 (IC95 : [1.7 ; 20.4]) ainsi qu'une Fatigue sévère OR 5.4 (IC95 : [1.2 ; 24.1]). …”
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“…Inclusion criteria: (1) age ≥ 60; (2) Speak clearly, have normal hearing, and be able to correctly understand and answer the questionnaire in groups; (3) I am willing to participate in this study and sign the informed consent form. Exclusion criteria: (1) local residents < 6 months; (2) There are serious physical group diseases and cannot cooperate with the investigators. …”
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“…Methods This cross sectional, multi-center, observational study included CLL patients, treatment naïve during the watch & wait period (W&W) or already TREATED (around 50% each, controlled at site level), who signed the informed consent for study participation. …”
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“…She also required amlodipine for hypertension. There was no sign of MAS remission (table 1), and the decision was made to commence etoposide (initial 150mg/M2 for 6 doses; current dose 50mg/M2) whilst working our patient up for a HSCT eight months after first presentation. …”
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“…The abdomen was rigid with positive Murphy’s sign. There were no joint or skin anomalies. She was admitted under the surgical team for further investigation. …”
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“…Sensitivity analysis was used to evaluate whether the pooled effect sizes were robust across components of methodological quality, in relation to inclusion of a primary study result with an unclear sign, inclusion of effect sizes from the STAR experiment and to using a one‐student reduction in class size in studies using class size as a continuous variable. …”
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“…These toxic gasses will cause severe tissue hypoxia without significant vital sign changes.5 The respiratory distress and metabolic compromise will be acutely more fatal than the obvious external injuries and burns. …”
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“…Hemispherx and AOP Orphan Pharmaceuticals have signed a marketing agreement for Ampligen® for the treatment of chronic fatigue syndrome for Austria, the Czech Republic, Poland and Hungary. …”
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“…Men or women 18 to 80 years of age inclusive, at the time of signing the informed consent. 2. Willing and able to provide informed consent. 3. …”
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“…Fertile women* must not be pregnant, i.e. negative pregnancy test must be available at inclusion • Informed consent signed by the patient *Defined as after menarche and until postmenopausal (no menstruation for 12 months) Exclusion criteria: • At the time of recruitment, the patient uses >5 LO2/min (equivalent to 40% FiO2 if measured) • Known intolerance/allergy to azithromycin or hydroxychloroquine or hypersensitivity to quinine or 4-aminoquinoline derivatives • Neurogenic hearing loss • Psoriasis • Retinopathy • Maculopathy • Visual field changes • Breastfeeding • Severe liver diseases other than amoebiasis (INR> 1.5 spontaneously) • Severe gastrointestinal, neurological and hematological disorders (investigator-assessed) • eGFR <45 ml/min/1.73 m2 • Clinically significant cardiac conduction disorders/arrhythmias or prolonged QTc interval (QTc (f) of> 480/470 ms). • Myasthenia gravis • Treatment with digoxin* • Glucose-6-phosphate dehydrogenase deficiency • Porphyria • Hypoglycaemia (Blood glucose at any time since hospitalization of <3.0 mmol/L) • Severe mental illness which significantly impedes cooperation • Severe linguistic problems that significantly hinder cooperation • Treatment with ergot alkaloids *The patient must not be treated with digoxin for the duration of the intervention. …”
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“…Participants will only be included after signing the voluntary Informed Consent Form and ensuring they undergo screening evaluation and conform to all the inclusion and exclusion criteria. …”
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