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101“…This paper covers several recent discoveries on small RNA mediated virus–host interactions, and focuses on influenza virus cap-snatching and a few important virus sensors including PIR-1, RIG-I like protein DRH-1 and piRNAs. …”
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102“…By a process known as cap snatching, the virus steals short 5′ capped RNA fragments from host capped RNAs and uses them to prime viral transcription. …”
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103“…The auxiliary PB2 cap-binding and the PA endonuclease domains are both involved in cap snatching, but the role of the auxiliary PB2 627 domain, implicated in host range restriction of influenza A viruses, is still poorly understood. …”
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104mSphere of Influence: Resolution of the Structure of an Influenza Virus Polymerase Is a Game Changerpor Richard, Mathilde“…Cusack (Nature 516:355–360, 2014, https://doi.org/10.1038/nature14008) and “Structural Insight into Cap-Snatching and RNA Synthesis by Influenza Polymerase” by S. …”
Publicado 2019
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105“…The cap is either synthetized by a subset of viral or cellular enzymes, or stolen from capped cellular mRNAs by viral endonucleases (‘cap-snatching’). Reverse genetic studies provide evidence that inhibition of viral enzymes belonging to the capping pathway leads to inhibition of virus replication. …”
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106“…Replication and transcription of the viral genome is performed by ~250–450 kDa viral RNA-dependent RNA polymerases that also contain capping or cap-snatching activity. In this Review, we compare recent high-resolution X-ray and cryoelectron microscopy structures of RNA polymerases of negative-sense RNA viruses with segmented and non-segmented genomes, including orthomyxoviruses, peribunyaviruses, phenuiviruses, arenaviruses, rhabdoviruses, pneumoviruses and paramyxoviruses. …”
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107“…A short, capped primer, ′cap-snatched′ from a nascent host polymerase II transcript, is directed towards the polymerase active site to initiate RNA synthesis. …”
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108por Ntombela, Berrington Xolani Siphosakhe“…While there has been a drive to argue for the relevance and importance of education through local languages, English has snatched the biggest slice of the cake by subtly imposing itself as the sole global language of education. …”
Publicado 2023
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109por Datta, Kausiki, Wolkerstorfer, Andrea, Szolar, Oliver H. J., Cusack, Stephen, Klumpp, Klaus“…Influenza virus uses a unique cap-snatching mechanism characterized by hijacking and cleavage of host capped pre-mRNAs, resulting in short capped RNAs, which are used as primers for viral mRNA synthesis. …”
Publicado 2013
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110por Park, Suk-Youl, Park, Jung-Eun, Kim, Tae-Sung, Kim, Ju Hee, Kwak, Mi-Jeong, Ku, Bonsu, Tian, Lan, Murugan, Ravichandran N., Ahn, Mija, Komiya, Shinobu, Hojo, Hironobu, Kim, Nam-Hyung, Kim, Bo Yeon, Bang, Jeong K., Erikson, Raymond L., Lee, Ki Won, Kim, Seung Jun, Oh, Byung-Ha, Yang, Wei, Lee, Kyung S.“…The Cep152-peptide bound to the CPB markedly better than the Cep192-peptide and effectively snatched the CPB away from a preformed CPB–Cep192-peptide complex. …”
Publicado 2014
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111“…These include: (a) generating cap 1 structures on their RNA through cap-snatching or virally-encoded 2′-O methyltransferases, (b) using cap-independent means of translation, or (c) using RNA secondary structural motifs to antagonize IFIT1 binding. …”
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112por Thierry, Eric, Guilligay, Delphine, Kosinski, Jan, Bock, Thomas, Gaudon, Stephanie, Round, Adam, Pflug, Alexander, Hengrung, Narin, El Omari, Kamel, Baudin, Florence, Hart, Darren J., Beck, Martin, Cusack, Stephen“…In recent structures of promoter-bound polymerase, the cap-binding and endonuclease domains are configured for cap snatching, which generates capped transcription primers. …”
Publicado 2016
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113por Li, Bo, Clohisey, Sara M., Chia, Bing Shao, Wang, Bo, Cui, Ang, Eisenhaure, Thomas, Schweitzer, Lawrence D., Hoover, Paul, Parkinson, Nicholas J., Nachshon, Aharon, Smith, Nikki, Regan, Tim, Farr, David, Gutmann, Michael U., Bukhari, Syed Irfan, Law, Andrew, Sangesland, Maya, Gat-Viks, Irit, Digard, Paul, Vasudevan, Shobha, Lingwood, Daniel, Dockrell, David H., Doench, John G., Baillie, J. Kenneth, Hacohen, Nir“…We also find that CMTR1, a human mRNA cap methyltransferase, is required for efficient viral cap snatching and regulation of a cell autonomous immune response, and provides synergistic protection with the influenza endonuclease inhibitor Xofluza.…”
Publicado 2020
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114“…Outbreak of Coronavirus (SARS-CoV-2) has thrown a big challenge to the globe by snatching millions of human lives from the world. In this study, inhibitory efficiency of ten anti-HIV compounds from different Indian medicinal plant parts have been virtually screened against Mpro, PLpro and RdRp proteins of SARS-CoV-2. …”
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115“…IAV, on the other hand, uses the pause to acquire the capped primers necessary to initiate viral transcription through cap-snatching. Finally, the HDV RNA genome is transcribed directly by RNAP II and requires the small hepatitis delta antigen to displace NELF from the polymerase and overcome the transcriptional block caused by RNAP II promoter-proximal pausing. …”
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116“…Ten healthy volunteers conducted three lifting methods (snatching, pushing, and pulling) for manhole cover using a custom-made tool weighting 20 and 30 kg. …”
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117por Law, Michelle Cheok Yien, Zhang, Kuo, Tan, Yaw Bia, Nguyen, Trinh Mai, Luo, Dahai“…This decapping activity could promote cellular mRNA degradation and facilitate viral gene expression, which is functionally analogous to the cap-snatching mechanism by influenza virus.…”
Publicado 2023
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118“…Although no relevant porcine pathogens have been shown to be causally associated, inoculation of susceptible pigs using tissue homogenates is needed to rule out infectious etiologies. Eight snatched-farrowed porcine-colostrum-deprived (SF-pCD) pigs were inoculated with tissue homogenates made from PFTS-affected pigs orally, or combined orally, intraperitoneally (IP) and intramuscularly (IM) at day (D) 14 of age (INOC). …”
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119“…CASE SUMMARY: Here with we report a rare case of 20 yrs old male who is a daily wage labourer with 600 ml of fevicol inhalant abuse and dependence along with alcohol, cannabis and nitrazepam abuse with ASPD traits,multiple criminal activities like robbery of mobiles, bikes, car,money, chain snatching etc along with friends senior to him from age 8 yrs and punished legally twice at age 12 yrs and 15 yrs. …”
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120por Tsiktsiris, Dimitris, Dimitriou, Nikolaos, Lalas, Antonios, Dasygenis, Minas, Votis, Konstantinos, Tzovaras, Dimitrios“…The proposed system can identify abnormal passenger behavior such as vandalism and accidents but can also enhance passenger security via petty crimes detection such as aggression, bag-snatching, and vandalism. The solution achieves excellent results across different use cases and environmental conditions.…”
Publicado 2020
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