Mostrando 181 - 200 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.19s Limitar resultados
  1. 181
    “…While the two major cannabinoids cannabidiol and trans-Δ(9)-tetrahydrocannabinol were largely ineffective in inhibiting SOCE, we report for the first time that several minor cannabinoids, mainly the carboxylic acid derivatives and particularly cannabigerolic acid, demonstrated high potency against SOCE by blocking calcium release-activated calcium currents. …”
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    Acidic Cannabinoids Suppress Proinflammatory Cytokine Release by Blocking Store-operated Calcium Entry
  2. 182
    “…In any case, the molecular determinants responsible for SOCE in human skeletal muscle and for dysregulated SOCE in patients of muscular dystrophy require further examination.…”
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    STIM1 as a key regulator for Ca(2+ )homeostasis in skeletal-muscle development and function
  3. 183
    “…In addition, several anti-cancer drugs have been reported to induce apoptosis of cancer cells via the SOCE pathway. However, the detailed mechanism underlying the regulation of SOCE by Bcl-2 is not well understood. …”
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    Bcl-2 regulates store-operated Ca(2+) entry to modulate ER stress-induced apoptosis
  4. 184
    “…Store-operated Ca(2+) entry (SOCE) is a ubiquitous type of Ca(2+) influx involved in various cellular functions. …”
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    Enhanced Store-Operated Ca(2+) Signal of Small Intestinal Smooth Muscle Cells Accelerates Small Bowel Transit Speed in Type 1 Diabetic Mouse
  5. 185
    por Hasan, Gaiti, Venkiteswaran, Gayatri
    Publicado 2010
    “…Both intracellular Ca(2+)-release and SOCE appear to function in neuro-modulatory domains of the flight circuit during development and acute flight. …”
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    The Enigma of Store-Operated Ca(2+)-Entry in Neurons: Answers from the Drosophila Flight Circuit
  6. 186
    por Richhariya, Shlesha, Hasan, Gaiti
    Publicado 2017
    “…Interestingly, unlike in the nervous system, Ral expression in the muscle is not regulated by SOCE. Moreover, either knockdown or genetic inhibition of SOCE in muscles does not affect flight. …”
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    Ral function in muscle is required for flight maintenance in Drosophila
  7. 187
    “…These observations demonstrate that ERK1/2 is activated by a selective mechanism of Ca(2+) entry (SOCE) in these cells, and suggest that ERK1/2 may contribute to events downstream of SOCE.…”
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    Activation of ERK1/2 by Store-Operated Calcium Entry in Rat Parotid Acinar Cells
  8. 188
    “…Convergent regulation by IP(3)Rs, may tune neuronal SOCE to respond selectively to receptors that generate IP(3).…”
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    Regulation of store-operated Ca(2+) entry by IP(3) receptors independent of their ability to release Ca(2+)
  9. 189
    “…These findings demonstrate that SOCE is an important mechanism for healthy hepatic Ca(2+) balance and systemic metabolic control.…”
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    Defective STIM-mediated store operated Ca(2+) entry in hepatocytes leads to metabolic dysfunction in obesity
  10. 190
    “…Flight circuit development in Drosophila requires store-operated calcium entry (SOCE) through the STIM/Orai pathway. SOCE-associated flight deficits in adult Drosophila derive extensively from regulation of gene expression in pupal neurons, and one such SOCE-regulated gene encodes the small GTPase Ral. …”
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    dSTIM- and Ral/Exocyst-Mediated Synaptic Release from Pupal Dopaminergic Neurons Sustains Drosophila Flight
  11. 191
    “…In addition, STIM1‐mediated SOCE exerted an antiapoptotic effect via the MEK/ERK pathway. …”
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    Inhibition of stromal‐interacting molecule 1‐mediated store‐operated Ca(2+) entry as a novel strategy for the treatment of acquired imatinib‐resistant gastrointestinal stromal tumors
  12. 192
    “…However, the effects of insulin action on store-operated Ca(2+) entry (SOCE) in podocytes remain unknown. Here, we demonstrated that insulin stimulates SOCE by VAMP2-dependent Orai1 trafficking to the plasma membrane. …”
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    Insulin-activated store-operated Ca(2+) entry via Orai1 induces podocyte actin remodeling and causes proteinuria
  13. 193
    “…ER Ca(2+) depletion initiates the oligomerization of stromal interaction molecules (STIM) that control SOCE activation, but whether ER Ca(2+) refilling controls STIM de-oligomerization and SOCE termination is not known. …”
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    Local Cytosolic Ca(2+) Elevations Are Required for Stromal Interaction Molecule 1 (STIM1) De-oligomerization and Termination of Store-operated Ca(2+) Entry
  14. 194
    “…Since fMLP activates Nox2 by elevation in [Ca(2+)](i) via fluxes such as inositol 1,4,5-trisphosphate-induced Ca(2+) release (IICR) and store-operated Ca(2+) entry (SOCE), we also evaluated the effects of shikonin on IICR and SOCE. …”
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    Inhibition of neutrophil superoxide generation by shikonin is associated with suppression of cellular Ca(2+) fluxes
  15. 195
    “…Store-operated Ca(2+) entry (SOCE) mediates the increase in intracellular calcium (Ca(2+)) in endothelial cells (ECs) that regulates several EC functions including tissue-fluid homeostasis. …”
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    STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca(2+) Entry
  16. 196
    “…Here we derived human neural precursor cells (NPCs) from human embryonic stem cells to understand the functional significance of a less understood arm of calcium signaling, Store-operated Ca(2+) entry or SOCE, in neuronal development. Human NPCs exhibited robust SOCE, which was significantly attenuated by expression of a stable shRNA-miR targeted toward the SOCE molecule, STIM1. …”
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    Stable STIM1 Knockdown in Self-Renewing Human Neural Precursors Promotes Premature Neural Differentiation
  17. 197
    “…Collectively, our data suggests that MRGPRX2/MrgprB2 activation of mast cells is dependent on SOCE via STIM1, and further characterization of the MRGPRX2-SOCE-STIM1 pathway will lead to the identification of novel targets for the treatment of pseudo-allergic reactions in humans.…”
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    Store-Operated Calcium Entry via STIM1 Contributes to MRGPRX2 Induced Mast Cell Functions
  18. 198
    “…Genetic manipulations with TRPP2 siRNA, dominant negative TRPP2 or STIM1 siRNA significantly suppressed ATP and TG-induced intracellular Ca(2+) release and SOCE in HEK293 cells. Inositol triphosphate receptor inhibitor 2-aminoethyl diphenylborinate (2APB) abolished ATP-induced Ca(2+) release and SOCE in HEK293 cells. …”
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    TRPP2 and STIM1 form a microdomain to regulate store-operated Ca(2+) entry and blood vessel tone
  19. 199
    “…RESULTS: High glucose significantly increased Ca(2+) influx by abnormally activating SOCE in EA and MOVAS cells. Notably, this high glucose-induced increase in SOCE was restored to normal levels in EA and MOVAS cells by Rg-1. …”
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    Ginsenoside Rg-1 prevents elevated cytosolic Ca(2+) via store-operated Ca(2+) entry in high-glucose–stimulated vascular endothelial and smooth muscle cells
  20. 200
    “…Our data indicate that SOCE inhibition may be a suitable new approach for the treatment of IBD.…”
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    Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease
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