Mostrando 261 - 280 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.22s Limitar resultados
  1. 261
    por Berna-Erro, A, Woodard, G E, Rosado, J A
    Publicado 2012
    “…The stromal interaction molecules STIM1 and STIM2 are Ca(2+) sensors, mostly located in the endoplasmic reticulum, that detect changes in the intraluminal Ca(2+) concentration and communicate this information to plasma membrane store-operated channels, including members of the Orai family, thus mediating store-operated Ca(2+) entry (SOCE). Orai and STIM proteins are almost ubiquitously expressed in human cells, where SOCE has been reported to play a relevant functional role. …”
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    Orais and STIMs: physiological mechanisms and disease
  2. 262
    “…The SOCE pathway is activated by the ligand-induced depletion of the ER calcium store. …”
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    STIM Proteins: An Ever-Expanding Family
  3. 263
    por Dagan, Inbal, Palty, Raz
    Publicado 2021
    “…The identification of the SOCE-associated regulatory factor (SARAF) and investigations of its role in SCDI have led to new functional and molecular insights into how SOCE is controlled. …”
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    Regulation of Store-Operated Ca(2+) Entry by SARAF
  4. 264
    “…Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. …”
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    Store-independent modulation of Ca(2+) entry through Orai by Septin 7
  5. 265
    “…These results suggest that SOCE plays an important role in neuronal regeneration, and mutations in ATL1 may cause HSP, partly by undermining SOCE.…”
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    Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth
  6. 266
    “…Store-operated Ca(2+) entry (SOCE), mediated by the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) and the plasma membrane (PM) channel Orai1, is inhibited during mitosis. …”
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    Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis
  7. 267
    “…These include the Orai1 protein, which is known as an important SOCE actor in various cell systems, including human PCa cells. …”
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    Bisphenol A stimulates human prostate cancer cell migration via remodelling of calcium signalling
  8. 268
    “…Putative Akt targets include store-operated Ca(2+)-entry (SOCE) accomplished by pore forming ion channel unit Orai1 and its regulator STIM1. …”
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    Enhanced Orai1 and STIM1 expression as well as store operated Ca(2+) entry in therapy resistant ovary carcinoma cells
  9. 269
    “…In the central nervous system (CNS), they are involved mainly in Orai-mediated store-operated Ca(2+) entry (SOCE). The key molecular components of the SOCE pathway are well-characterized, but the molecular mechanisms that underlie the regulation of this pathway need further investigation. …”
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    Target Molecules of STIM Proteins in the Central Nervous System
  10. 270
    “…We tagged endogenous STIM1 with EGFP using CRISPR/Cas9. SOCE evoked by loss of ER Ca(2+) was unaffected by the tag. …”
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    The store-operated Ca(2+) entry complex comprises a small cluster of STIM1 associated with one Orai1 channel
  11. 271
    “…Particularly, the Yoda1-induced increase in intracellular Ca(2+) ([Ca(2+)](i)) is partially abolished by 2-APB, a well-known inhibitor of SOCE. Flow cytometry analysis and wound healing assay showed that long-term activation of Piezo1 or SOCE does not have a cytotoxic effect on eMSCs but suppresses their migratory capacity and the rate of cell proliferation. …”
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    Store-Operated Ca(2+) Entry Contributes to Piezo1-Induced Ca(2+) Increase in Human Endometrial Stem Cells
  12. 272
    “…A remodeling of calcium homeostasis, including calcium influx via store-operated calcium entry (SOCE), is a feature of breast cancers. SOCE is critical to maintain calcium balance in the endoplasmic reticulum calcium store and is an important mechanism for calcium signaling in a variety of cell types, including breast cancer cells. …”
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    ORAI1-Regulated Gene Expression in Breast Cancer Cells: Roles for STIM1 Binding, Calcium Influx and Transcription Factor Translocation
  13. 273
    “…The IP(3) sponge also restored the elevation of SOCE and increased the release of Ca(2+) from the ER in YAC128 MSN cultures that overexpressed HAP1A. …”
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    Huntingtin-Associated Protein 1A Regulates Store-Operated Calcium Entry in Medium Spiny Neurons From Transgenic YAC128 Mice, a Model of Huntington’s Disease
  14. 274
    “…Increasing evidence supports that activation of store‐operated Ca(2+) entry (SOCE) is implicated in the chemoresistance of cancer cells subjected to chemotherapy. …”
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    Inhibition of Orai1‐mediated Ca(2+) entry enhances chemosensitivity of HepG2 hepatocarcinoma cells to 5‐fluorouracil
  15. 275
    “…Although cytoskeletal remodeling apparently contributes to calcium mobilization via SOCE, and vice versa, the mechanisms by which they regulate each other remain unclear. …”
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    Modulation of store-operated calcium entry and nascent adhesion by p21-activated kinase 1
  16. 276
    “…MiR-26a deficiency increases SOCE channel expression and [Ca(2+)](i) overload, and significantly exacerbates AP. …”
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    A microRNA checkpoint for Ca(2+) signaling and overload in acute pancreatitis
  17. 277
    “…Cytosolic Ca(2+) signals encoded by repetitive Ca(2+) releases rely on two processes to refill Ca(2+) stores: Ca(2+) reuptake from the cytosol and activation of a Ca(2+) influx via store-operated Ca(2+) entry (SOCE). However, SOCE activation is a slow process. …”
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    STIM1L is a new actin-binding splice variant involved in fast repetitive Ca(2+) release
  18. 278
    “…Molecular steps that activate store-operated calcium entry (SOCE) via Orai channel supramolecular complex remain incompletely defined. …”
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    High affinity associations with α-SNAP enable calcium entry via Orai1 channels
  19. 279
    “…Apoptotic cells induced calcium release from the endoplasmic reticulum, which led to the Orai1-STIM1 association and, consequently, SOCE in phagocytes. This association was attenuated by masking phosphatidylserine. …”
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    Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association
  20. 280
    “…Stromal interaction molecule 1 (STIM1), an ER transmembrane protein important for regulating store-operated Ca(2+) entry (SOCE), localizes to the inclusion membrane via an uncharacterized interaction. …”
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    Chlamydia trachomatis suppresses host cell store-operated Ca(2+) entry and inhibits NFAT/calcineurin signaling
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