Mostrando 281 - 300 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.10s Limitar resultados
  1. 281
    “…Excitingly, DPB162-AE, a SOCE inhibitor, suppressed BIRD-2-induced cell death in DLBCL cells. …”
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    Extracellular and ER-stored Ca(2+) contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells
  2. 282
    “…We found that SOCE components—stromal interacting molecules 1 and 2 (STIM1, STIM2) and ORAI3 (SOCE) channel were upregulated in these crystal-internalized cells, which induced ER stress, ROS production, and cell death. …”
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    Abrogation of store-operated Ca(2+) entry protects against crystal-induced ER stress in human proximal tubular cells
  3. 283
    “…BACKGROUND: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca(2+) entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor of cardiac hypertrophy and heart failure but the relevance of Orai1 is still unclear. …”
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    Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca(2+) Handling After Pressure Overload
  4. 284
    “…Our data shows no evidence of significant insertion of Orai1 or TRPC subunits into the membrane during SOCE. Analysis of transmission electron microscopy data shows that during store-depletion and SOCE, Orai1 and TRPC subunits form separate membrane-localized clusters that migrate towards each other. …”
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    TRPC1 channel clustering during store-operated Ca(2+) entry in keratinocytes
  5. 285
    “…However, the pharmacological inhibition of SOCE prevented BC-ECFC proliferation and in vitro tubulogenesis. …”
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    VEGF-induced intracellular Ca(2+) oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells
  6. 286
    “…BACKGROUND: Store-operated Ca(2+) entry (SOCE) has been implicated in the migration of some cancer cell lines. …”
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    Arachidonic acid-induced Ca(2+) entry and migration in a neuroendocrine cancer cell line
  7. 287
    “…Transient receptor potential canonical-6 (TRPC6) is a Ca(2+)-permeable cation channel that regulates store-operated calcium entry (SOCE) and is a candidate risk gene for ASD. Using human pluripotent stem cell (hPSC)–derived cortical neurons, single-cell calcium imaging, and electrophysiological recording, we show that TRPC6 knockout (KO) reduces SOCE signaling and leads to hyperexcitability of neurons by increasing action potential frequency and network burst frequency. …”
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    Deletion of TRPC6, an Autism Risk Gene, Induces Hyperexcitability in Cortical Neurons Derived from Human Pluripotent Stem Cells
  8. 288
    por Yu, Fang, Sun, Lu, Machaca, Khaled
    Publicado 2010
    “…To endow the egg with this capacity, Ca(2+) signals remodel during oocyte maturation, including inactivation of the primary Ca(2+) influx pathway store-operated Ca(2+) entry (SOCE). SOCE inactivation is coupled to internalization of the SOCE channel, Orai1. …”
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    Constitutive recycling of the store-operated Ca(2+) channel Orai1 and its internalization during meiosis
  9. 289
    “…We determine that NPC1 inhibition or disease mutations potentiate store-operated Ca(2+) entry (SOCE) due to a presenilin 1 (PSEN1)–dependent reduction in ER Ca(2+) levels alongside elevated expression of the molecular SOCE components ORAI1 and STIM1. …”
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    Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity
  10. 290
    “…T cell activation and function depend on Ca(2+) signals mediated by store-operated Ca(2+) entry (SOCE) through Ca(2+) release–activated Ca(2+) (CRAC) channels formed by ORAI1 proteins. …”
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    Distinct roles of ORAI1 in T cell–mediated allergic airway inflammation and immunity to influenza A virus infection
  11. 291
    “…Exploration into the roles of P100 and CTF in SOCE inhibition reveal that P100, when expressed in Xenopus laevis oocytes, directly inhibits the SOCE currents but CTF does not, nor does P100 when containing the disease causing R4227X mutation. …”
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    Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca(2+) Entry through Interactions with STIM1
  12. 292
    “…In addition, ROCE and SOCE were abolished by SKF-96365 (50 μM) and 2-aminoethyl diphenylborinate (100 μM), and were slightly decreased in the presence of diltiazem (10 μM). …”
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    Activity of Ca(2+) -activated Cl(-) channels contributes to regulating receptor- and store-operated Ca(2+) entry in human pulmonary artery smooth muscle cells
  13. 293
    “…OBJECTIVES: The aim of this study is to examine the potential links between SOCE and the circadian clock during amelogenesis. …”
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    Calcium Sets the Clock in Ameloblasts
  14. 294
    “…The likely underlying mechanism is inhibition of SOCE, as shown for its synthetic sulfamate ester analogue 2-ethyl-3-sulfamoyloxy-17β-cyanomethylestra-1,3,5(10)-triene (STX564). …”
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    2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca(2+) entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis
  15. 295
    por Kappel, Sven, Peinelt, Christine
    Publicado 2022
    “…In these cells, pharmacological inhibition of store‐operated calcium entry (SOCE) reduced cytokine production. In addition, in a murine IBD model, systemic SOCE inhibition reduced IBD severity and weight loss.…”
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    Targeting CRAC channels in inflammatory bowel disease
  16. 296
    “…Concomitantly STIM1-TRPC1 complex was also impaired that was essential for SOCE and sustained Ca(2+) entry. Likewise loss of SOCE due to PL further inhibited NFkB activation. …”
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    Helminth Induced Suppression of Macrophage Activation Is Correlated with Inhibition of Calcium Channel Activity
  17. 297
    “…Our study thus shows that FGF4 induces EMT by elevating SOCE in lung ADC.…”
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    FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma
  18. 298
    “…Store-operated Ca(2+) entry (SOCE) encodes a range of cellular responses downstream of Ca(2+) influx through the SOCE channel Orai1. …”
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    The CCT chaperonin is a novel regulator of Ca(2+) signaling through modulation of Orai1 trafficking
  19. 299
    “…Thus, aberrant SOCE could contribute to muscle disorders associated with loss of TRIC-A.…”
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    TRIC-A shapes oscillatory Ca(2+) signals by interaction with STIM1/Orai1 complexes
  20. 300
    “…Mechanistically, we link these roles of EHD2 to store-operated calcium entry (SOCE), with EHD2-dependent stabilization of plasma membrane caveolae ensuring high cell surface expression of the SOCE-linked calcium channel Orai1. …”
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    EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry
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