Mostrando 301 - 320 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.16s Limitar resultados
  1. 301
    “…SOCE is triggered by a reduction of Ca(2+) content (i.e. depletion) in intracellular stores, i.e. endoplasmic or sarcoplasmic reticulum (ER and SR). …”
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    Calcium entry units (CEUs): perspectives in skeletal muscle function and disease
  2. 302
    “…Filopodia lack any Ca(2+)-binding structural protein but respond to store-operated Ca(2+) entry (SOCE). METHODS: SOCE was induced by first replacing the medium with Ca(2+)-free salt solution with cyclopiazonic acid (CPA). …”
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    How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP
  3. 303
    “…Both agonists induce calcium release from endoplasmic reticulum (ER) stores and store operated calcium entry (SOCE) likely via STIM/ORAI-based channels. siRNA mediated knockdown (KD) of obligate calcium sensors STIM1 and STIM2 decreased the magnitude of muscarinic agonist induced oscillatory calcium release and attenuated SOCE in hOPCs. …”
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    Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells
  4. 304
    “…Acute inhibition of GSK3 blunted the increase of [Ca(2+)](i) following CRIS and SOCE and stimulated NCKX/NCX activity. However, expression of PKB/SGK-resistant GSK3α, β downregulated the increase of [Ca(2+)](i) following CRIS and SOCE, an effect at least partially due to downregulation of Orai1, STIM1 and STIM2 expression as well as upregulation of Na(+)/Ca(2+)-exchanger activity and calbindin D28k expression.…”
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    Decreased Store Operated Ca(2+) Entry in Dendritic Cells Isolated from Mice Expressing PKB/SGK-Resistant GSK3
  5. 305
    “…The latter involves the activation of Orai and TRPC6 channels, while the increase of SOCE observed in ppFurin-expressing cells is entirely dependent on Orai channels. …”
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    Furin Prodomain ppFurin Enhances Ca(2+) Entry Through Orai and TRPC6 Channels’ Activation in Breast Cancer Cells
  6. 306
    “…Store-operated calcium entry (SOCE), the main pathway allowing Ca(2+) entry in non-excitable cells, is involved in tumorogenesis, cancer progression and chemoresistance. …”
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    Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma
  7. 307
    “…Store-operated calcium entry (SOCE) constitutes a fine-tuning mechanism responsible for the replenishment of intracellular stores. …”
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    Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease
  8. 308
    “…Orai1 and STIM1 are critical components of Ca(2+) release-activated Ca(2+) (CRAC) channels that mediate store-operated Ca(2+) entry (SOCE) in immune cells. While Orai1 and STIM1 co-cluster and physically interact to mediate SOCE, the cytoplasmic machinery modulating these functions remains poorly understood. …”
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    A novel EF-hand protein, CRACR2A, is a cytosolic Ca(2+) sensor that stabilizes CRAC channels in T cells
  9. 309
    “…STIMs (STIM1 and STIM2 in mammals) are transmembrane proteins that reside in the endoplasmic reticulum (ER) and regulate store-operated Ca(2+) entry (SOCE). The function of STIMs in the brain is only beginning to be explored, and the relevance of SOCE in nerve cells is being debated. …”
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    STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs
  10. 310
    “…These results demonstrated that SOCE regulates membrane ruffling at the leading edge of cells. …”
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    Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains
  11. 311
    “…Taken together, our study suggests that FGF2 promotes metastasis of UM via SOCE.…”
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    FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry
  12. 312
    “…It inhibited store-operated calcium entry (SOCE) and Mcl-1 translation through mTORC1 deactivation. …”
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    Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-Bclx(L) strategies through Mcl-1 down-regulation
  13. 313
    “…Furthermore, the SOCE response of I-type cells, a presumed precursor to both N- and S-type cells, varied markedly in different cell environments. …”
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    Differentiation-Induced Remodelling of Store-Operated Calcium Entry Is Independent of Neuronal or Glial Phenotype but Modulated by Cellular Context
  14. 314
    “…Overall, we have demonstrated different roles of STIM1 and E-syt1 in MCS formation regulation, SOCE activation and ER Ca(2+) store replenishment.…”
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    E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca(2+) Store Replenishment
  15. 315
    “…In this respect, it has been recently proposed that altered astrocytic store-operated Ca(2+) entry (SOCE) may underlie aberrant gliotransmitter release and astrocyte-mediated neurotoxicity in ALS. …”
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    ALS-Associated SOD1(G93A) Decreases SERCA Pump Levels and Increases Store-Operated Ca(2+) Entry in Primary Spinal Cord Astrocytes from a Transgenic Mouse Model
  16. 316
    “…In HEK293T cells, enhanced free basal cytosolic Ca(2+) and SOCE mediated by STIM2 overexpression could be attenuated by GSNO or mutation of the modifiable Cys located in the luminal domain. …”
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    Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry
  17. 317
    “…SOCE is triggered by stromal interaction molecule 1 (STIM1), which is located in endoplasmic reticulum (ER) as Ca(2+) sensor. …”
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    Blocking of stromal interaction molecule 1 expression influence cell proliferation and promote cell apoptosis in vitro and inhibit tumor growth in vivo in head and neck squamous cell carcinoma
  18. 318
    “…One of the major Ca(2+) signaling pathways is store-operated Ca(2+) entry (SOCE), which is responsible for Ca(2+) flow into cells in response to the depletion of endoplasmic reticulum Ca(2+) stores. …”
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    Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington’s Disease
  19. 319
    “…Inhibiting the activation of PDE1C reduced the magnitude of both SOCE and subsequent Ca(2+)/calmodulin–mediated activation of ADCY8 in these cells. …”
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    Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes
  20. 320
    “…Store-operated calcium entry (SOCE) is significantly remodeled in breast cancer cells and supports a variety of cancer hallmarks. …”
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    Orai2 Modulates Store-Operated Ca(2+) Entry and Cell Cycle Progression in Breast Cancer Cells
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