Mostrando 321 - 340 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.15s Limitar resultados
  1. 321
    “…The PLC inhibitor, U73122 (1 μM, 48 h), reduced the migration, decreased SOCE and TRP currents, and lowered p-PLCβ3 in atrial fibroblasts, similar to Klotho. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry
  2. 322
    “…STIM1, a recognized CaMBP, plays a key role in store-operated calcium entry (SOCE), and it has been shown that the SOCE function is diminished in AD, resulting in the instability of dendric spines and enhanced amyloidogenesis. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Internalized Amyloid-β (1-42) Peptide Inhibits the Store-Operated Calcium Entry in HT-22 Cells
  3. 323
    por Demaurex, Nicolas, Saul, Stephanie
    Publicado 2018
    “…Stromal interaction molecule (STIM) proteins regulate store‐operated Ca(2+) entry (SOCE) in innate and adaptive immune cells and participate in the Ca(2+) signals that control the functions of neutrophils, the first line of host defence against bacterial and fungal infections. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The role of STIM proteins in neutrophil functions
  4. 324
    “…Unlike wild-type STIM1, there was no further increase of SOCE by R429C. R429C bound to endogenous STIM1 and slowed down the initial rate of SOCE that were mediated by endogenous STIM1. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    A muscular hypotonia-associated STIM1 mutant at R429 induces abnormalities in intracellular Ca(2+) movement and extracellular Ca(2+) entry in skeletal muscle
  5. 325
    “…Store-operated calcium entry (SOCE), whereby the depletion of intracellular stores induces extracellular calcium influx, is known to be a crucial element of NADPH oxidase regulation. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Regulation of superoxide production in neutrophils: role of calcium influx
  6. 326
    “…The process of store-operated Ca(2+) entry (SOCE), whereby Ca(2+) influx across the plasma membrane is activated in response to depletion of intracellular Ca(2+) stores in the endoplasmic reticulum (ER), has been under investigation for greater than 25 years; however, only in the past 5 years have we come to understand this mechanism at the molecular level. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Activation and regulation of store-operated calcium entry
  7. 327
    “…One of the most crucial actors regulating Ca(2+) homeostasis is store-operated Ca(2+) channels, which mediate store-operated Ca(2+) entry (SOCE). This review focuses on the main actors of SOCE in human and experimental PASMC, their contribution to PAH pathogenesis, and their therapeutic potential in PAH.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Role of Store-Operated Ca(2+) Entry in the Pulmonary Vascular Remodeling Occurring in Pulmonary Arterial Hypertension
  8. 328
    “…Human CLCA2 regulates store-operated calcium entry (SOCE) by interacting with Orai1 and STIM1. It is expressed as a 943aa type I transmembrane protein that is cleaved at amino acid 708 to produce a diffusible 100 kDa product. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Self-Cleavage of Human Chloride Channel Accessory 2 Causes a Conformational Shift That Depends on Membrane Anchorage and Is Required for Its Regulation of Store-Operated Calcium Entry
  9. 329
    “…Importantly, perturbations in SOCE have been implicated in a spectrum of pathological neurodegenerative conditions. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Calcium Signaling Regulates Autophagy and Apoptosis
  10. 330
    “…The mechanisms underlying SOCE that were PSG9 enhanced in HUVECs appear to involve the Ca(2+)/eNOS/NO signaling pathway. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Pregnancy-Specific Glycoprotein 9 Enhances Store-Operated Calcium Entry and Nitric Oxide Release in Human Umbilical Vein Endothelial Cells
  11. 331
    “…Recently, AKAP79 has been reported to directly bind to adenylyl cyclase type 8 (AC8) and to regulate its responsiveness to store-operated Ca(2+) entry (SOCE). Although AKAP79 is well targeted to the plasma membrane via phospholipid associations with three N-terminal polybasic regions, recent studies suggest that AKAP79 also has the potential to be palmitoylated, which may specifically allow it to target the lipid rafts where AC8 resides and is regulated by SOCE. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8
  12. 332
    “…Orai1 proteins have been recently identified as subunits of SOCE (store-operated Ca(2+) entry) channels. In primary isolated PACs (pancreatic acinar cells), Orai1 showed remarkable co-localization and co-immunoprecipitation with all three subtypes of IP(3)Rs (InsP(3) receptors). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    InsP(3) receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences
  13. 333
    “…RESULTS: Hypoxia increased the basal [Ca(2+)](i) and SOCE in both freshly dissociated and serum cultured distal PVSMCs. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Chronic Hypoxia Increases TRPC6 Expression and Basal Intracellular Ca(2+) Concentration in Rat Distal Pulmonary Venous Smooth Muscle
  14. 334
    “…We demonstrated significantly increased SOCE after siRNA targeting of TRPM4 in hPEC and DU145 cells. …”
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells
  15. 335
    “…STIM1 and Orai1 knockdown significantly impaired SOCE and the increase of intracellular Ca(2+) by the GPR40 agonist, fasiglifam. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    GPR40 activation initiates store-operated Ca(2+) entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells
  16. 336
    “…Further, results showed that the diminished SOCE was caused by NEDD4L-mediated ubiquitination of Orai1 protein. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells
  17. 337
    “…While the ER-PM junctions were reduced in both HeLa and Jurkat T cells deleted for ESYT1 and ESYT2, SOCE was impaired only in Jurkat T cells, suggesting that the membrane-tethering function of E-Syts is distinct from their role in SOCE. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The short isoform of extended synaptotagmin-2 controls Ca(2+) dynamics in T cells via interaction with STIM1
  18. 338
    “…Recent evidence suggests that store-operated calcium entry (SOCE) might play a role in angiogenesis. However, little is known regarding the role of SARAF, SOCE-associated regulatory factor, and Orai1, the pore-forming subunit of the store-operated calcium channel (SOCC), in angiogenesis. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis
  19. 339
    “…These results suggest that chronic cholinergic augmentation alleviates HF via normalization of both canonical RyR2‐mediated SR Ca release and non‐canonical hypertrophic Ca signaling via STIM1‐dependent SOCE.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Pyridostigmine improves cardiac function and rhythmicity through RyR2 stabilization and inhibition of STIM1‐mediated calcium entry in heart failure
  20. 340
    “…In estrogen receptor-positive breast cancer cells and non-small cell lung cancer (NSCLC) cells store-operated Ca(2+) entry (SOCE) is strongly dependent on Orai3 expression while in colorectal cancer and pancreatic adenocarcinoma cells Orai3 predominantly modulates SOCE. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Role of Orai3 in the Pathophysiology of Cancer
Herramientas de búsqueda: RSS