“…Store-operated Ca(2+) entry (SOCE) is a universal Ca(2+) influx pathway that is important for the function of many cell types. …”
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“…These results also suggest a novel function for SOCE, which can operate as a “selection” switch between closely localized channels.…”
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“…Store-operated Ca(2+) entry (SOCE) is a ubiquitous Ca(2+) influx mechanism triggered by depletion of Ca(2+) stores from the endoplasmic/sarcoplasmic reticulum (ER/SR). …”
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“…We used immunoblot experiments to find that parathyroid hormone significantly enhanced the expression of the Orai1 channel, a type of channel mediating SOCE, SOCE activity, and Orai1-mediated proliferation of HUVECs but did not increase Orai2 and Orai3. …”
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“…RESEARCH DESIGN AND METHODS: The activity of store-operated Ca(2+) entry (SOCE) was detected by calcium imaging after 7 days of high-glucose (HG) or normal-glucose (NG) exposure, the expression levels of Orais after HG treatment was detected by western blot analysis. …”
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“…Our study provides evidence that the mineralocorticoid pathway specifically promotes TRPC1/TRPC5-mediated SOCE in adult rat cardiomyocytes.…”
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“…Ca(2+) imaging indicated that NSCs exhibit store-operated Ca(2+) entries (SOCEs). Pharmacological blockade of SOCEs with SKF-96365, YM-58483 (also known as BTP2) or GSK-7975A resulted in decreased NSC proliferation and self-renewal, indicating a major role for SOCs in maintaining NSC activity within the area postrema. …”
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“…Store-operated Ca(2+) entry (SOCE) was blocked by the SOCE inhibitor diethylstilbestrol (DES), STIM1 silencing using RNA interference (RNAi), and expression of dominant/negative Orai1(R91W). …”
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“…Here we present evidence for the dynamic interaction between the SOCE-associated regulatory factor (SARAF), STIM1 and Orai1. …”
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“…Using confocal live cell imaging, Ca(2+) imaging and electrophysiology techniques, we demonstrated that depletion of the endoplasmic reticulum Ca(2+) stores induced STIM1 and STIM2 translocation, and that inhibition of STIM1 or blockage of Orai channels with pharmacological tools attenuated SOCE and SOC currents. Using the small inhibitory RNA knockdown approach, we identified STIM1, STIM2, Orai1, and Orai3 as the key components of SOCs mediating SOCE in DRG neurons. …”
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“…Knock down of SIK3 by specific shRNA inhibited tumorigenicty, expression of SOCE regulators and P-gp activity, suggesting SIK3 is an upstream mediator of SOCE induced calcium influx. …”
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“…Store-operated Ca(2+) entry (SOCE) is the major form of extracellular Ca(2+) influx following depletion of ER Ca(2+) stores and stromal interaction molecule 1 (STIM1) is a key molecule in the regulation of SOCE. …”
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“…RV-induced [Ca(2+)]cyt spikes were primarily from ER calcium release and were attenuated by inhibiting the store-operated calcium entry (SOCE) channel Orai1. RV-infected HIEs also exhibited prominent [Ca(2+)]cyt spikes that were attenuated by inhibiting SOCE, underlining the relevance of these [Ca(2+)]cyt spikes to gastrointestinal physiology and role of SOCE in RV pathophysiology. …”
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“…The primary Ca(2+) influx pathway in oocytes is Store-Operated Ca(2+) Entry (SOCE). SOCE is tightly regulated during meiosis, including internalization of the SOCE channel, Orai1. …”
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“…P38MAPK and NFκB-dependent store-operated Ca(2+) entry (SOCE) are positive regulators of FGF23 production. …”
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“…Deletion of Orai3 did not affect SOCE in B cells and T cells but moderately enhanced SOCE in macrophages. …”
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“…We explore not only STIM1-Orai1 as drivers of SOCE, but also independent actions of STIM, and emerging signal cascades stemming from their activities. …”
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“…Through physiological and biochemical studies, in combination of genetic knockdown, we showed that ERα attenuated female colonic Cl(−) secretion but promoted Ca(2+)-dependent HCO(3)(−) secretion via store-operated calcium entry (SOCE) mechanism in mice. However, ERβ attenuated HCO(3)(−) secretion by inhibiting Ca(2+)via the SOCE and inhibiting cAMP via protein kinases. …”
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“…These results support a critical role for Ca(2+) regulatory proteins and enhanced SOCE to alter airway structure and function in smoking-related airway disease.…”
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“…We showed that K15P induced Ca(2+) influx and enhanced expression of Orail1, which is a vital protein in SOCE, and overexpression of K15P improved cell motility. …”
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