“…Finally, we blocked SOCE with 2-APB (2-Aminoethyl diphenylborinate), a pharmacological inhibitor. …”
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“…Unravelling the mystery: The mystery was finally solved in 2020, when we discovered that in Casq1-null mice the SR undergoes adaptations that result in constitutively active store-operated Ca(2+) entry (SOCE). SOCE is a mechanism that allows skeletal fibers to use external Ca(2+) when SR stores are depleted. …”
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“…We investigated the effect of SOCE blocker BTP2 on human peripheral blood mononuclear cells (PBMC) stimulated with the mitogen phytohemagglutinin (PHA). …”
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“…Altogether our data provide new insights into the mechanism of SOCE organization in podocytes in the norm and in pathology, which should be taken into account when developing pharmacological treatment of the early stages of diabetic nephropathy.…”
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“…Furthermore, MPO evoked a rise in cytosolic Ca(2+) through enhancement of store-operated Ca(2+) entry (SOCE). Together, these findings indicate that MPO is not a direct agonist but rather a mediator that binds to human platelets, induces actin cytoskeleton reorganization and affects the mechanical stiffness of human platelets, resulting in potentiating SOCE and agonist-induced human platelet aggregation. …”
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“…Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). The cytosolic region of STIM1 contains a long putative coiled-coil (CC)1 segment and shorter CC2 and CC3 domains. …”
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“…While STIM2 appears to play a minor role, STIM1 plays an important role in the regulation of agonist-induced Ca(2+) mobilization in BAECs by a positive effect on both the SOCE and the IP(3)R-dependent Ca(2+) release.…”
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“…Store-operated plasmalemmal Ca(2+) entry (SOCE) was measured with fura-2 based microfluorimetry. …”
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“…Store-operated Ca(2+) entry (SOCE), a Ca(2+) entry pathway modulated by mitochondria, is dramatically enhanced in colon cancer cells. …”
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“…An increase in cytosolic free Ca(2+) concentration promoted by store-operated Ca(2+) entry (SOCE) in pulmonary arterial smooth muscle cells (PASMCs) is a major trigger for pulmonary vasoconstriction and proliferation and migration of PASMCs. …”
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“…Our results demonstrate that the RPGR protein complex is required for regulating proteasomal activity and for modulating SOCE, which may contribute to the ciliopathy phenotype.…”
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“…We show that SOCE in gamma aminobutyric acid-ergic striatal medium spiny neurons (GABA MSNs) was mediated by currents through at least two different channel groups, I(CRAC) and I(SOC). …”
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“…Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca(2+) entry (SOCE) and calcineurin signaling. Upon miR-34a-5p overexpression, we observed both a decreased depletion of ER calcium content and a decreased Ca(2+) influx through Ca(2+) release-activated Ca(2+) channels. …”
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“…We show, using small interfering RNA (siRNA) and vacuolar H(+)-ATPase (V-ATPase) inhibitors, that lysosomes sequester Ca(2+) released by all IP(3)R subtypes, but not Ca(2+) entering cells through store-operated Ca(2+) entry (SOCE). A low-affinity Ca(2+) sensor targeted to lysosomal membranes reports large, local increases in cytosolic [Ca(2+)] during IP(3)-evoked Ca(2+) release, but not during SOCE. …”
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“…Store-operated Ca(2+) entry (SOCE) has been shown to be important for breast cancer metastasis in xenograft mouse models. …”
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“…In neurons, stromal interaction molecule (STIM) proteins regulate store-operated Ca(2+) entry (SOCE) and are involved in calcium signaling pathways. …”
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“…Perhaps the most well-understood mechanism of calcium influx into cells is store-operated calcium entry (SOCE), which occurs via calcium release-activated channels (CRACs). …”
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“…All these events give rise to store-operated calcium entry (SOCE). Besides the main pathway underlying SOCE, which mainly involves Orai1 and TRPC1 activation, STIM1 modulates many other plasma membrane proteins in order to potentiate the influxof Ca(2+). …”
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“…The CEU provides constitutive and store-operated Ca(2+) entry (SOCE) and resistance to force decline resulting from SR Ca(2+) depletion during repetitive muscle activity.…”
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