Mostrando 441 - 460 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.13s Limitar resultados
  1. 441
    “…NFAT nuclear translocation was significantly enhanced by hypoxia, which was dependent on SOCE and sensitive to SOC inhibitor SKF96365 (SKF), as well as cGMP analogue, 8-brom-cGMP. …”
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    Inhibition of SOC/Ca(2+)/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
  2. 442
    “…Therapeutic inhibition of SOCE may reduce the progression of cardiac fibrosis/HF.…”
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    Enhanced store-operated Ca(2+) influx and ORAI1 expression in ventricular fibroblasts from human failing heart
  3. 443
    “…In cells dying through non-apoptotic death, TQ increases endoplasmic reticulum (ER) stress markers and substantially increases cytosolic calcium ([Ca(2+)](c)) through ER calcium depletion and activation of store-operated calcium entry (SOCE). Chelation of [Ca(2+)](c), but not SOCE inhibitors, reduces TQ-induced non-apoptotic cell death, highlighting the critical role of calcium in a non-apoptotic effect of TQ. …”
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    Apoptotic and Non-Apoptotic Modalities of Thymoquinone-Induced Lymphoma Cell Death: Highlight of the Role of Cytosolic Calcium and Necroptosis
  4. 444
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    World Health Organization Regional Office for Africa Weekly Bulletin on Outbreaks and Other Emergencies
  5. 445
    “…An investigation into store release pathways indicated that Ca(2+) transients in mid-capillary pericytes occur through a combination of IP(3)R and RyR activation, and that Orai store-operated calcium entry (SOCE) is required to sustain and amplify intracellular Ca(2+) increases evoked by the GqGPCR agonist endothelin-1. …”
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    Orai, RyR, and IP(3)R channels cooperatively regulate calcium signaling in brain mid-capillary pericytes
  6. 446
    “…Pharmacological inhibition of SOCE mimicked this protection similarly to knockdown of ORAI1 by small interfering RNAs. …”
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    The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress
  7. 447
    “…We have examined the effects of the antibody GOK/STIM1, which recognises the N-terminal region of STIM1, on SOCE, agonist-stimulated Ca(2 +) entry, surface exposure, in vitro thrombus formation and aggregation in human platelets. …”
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    The role of plasma membrane STIM1 and Ca(2 +)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets
  8. 448
    “…Store-operated calcium (Ca(2+)) entry (SOCE) is the principal Ca(2+) entry route in non-excitable cells, including cancer cells. …”
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    Orai1 Expression Is Closely Related with Favorable Prognostic Factors in Clear Cell Renal Cell Carcinoma
  9. 449
    Publicado 2010
    “…This study could provide a basis for future exploration of the individual role of these TRPC proteins in mediating SOCE and in the progression of lung cancer.…”
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    经典瞬时受体电位通道蛋白在人非小细胞肺癌组织中的表达
  10. 450
    “…This SOCE was shown to play fundamental roles in the pathological remodelling of VSMC. …”
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    ORAI1 Ca(2+) Channel as a Therapeutic Target in Pathological Vascular Remodelling
  11. 451
    “…However, MβCD did not inhibit a Ca(2+) increase induced by thapsigargin, which activates store-operated Ca(2+) entry (SOCE). Interestingly, MβCD increased the activity of the large-conductance Ca(2+)-activated K(+) channel (BK channel). …”
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    Muscarinic Receptors and BK Channels Are Affected by Lipid Raft Disruption of Salivary Gland Cells
  12. 452
    “…Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. …”
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    Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells
  13. 453
    “…OBJECTIVE: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca(2+) entry (SOCE), an ancient and ubiquitous signaling pathway. …”
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    Disruption of STIM1-mediated Ca(2+) sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass
  14. 454
    “…In many cells, STIM1 (stromal interaction molecule 1), a single-transmembrane-domain protein that resides in the endoplasmic reticulum (ER), transiently moves to ER-PM junctions in response to depletion of ER Ca(2+) stores and initiates store-operated Ca(2+) entry (SOCE). Fully differentiated VSMCs express STIM1 but exhibit only marginal SOCE activity. …”
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    STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
  15. 455
    “…Orai1 is, together with STIM1, the key element of SOCE, conducting the Ca(2+) release-activated Ca(2+) (CRAC) current and, in association with TRPC1, the store-operated Ca(2+) (SOC) current. …”
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    Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
  16. 456
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    NTD programmes hold the key to universal health coverage and better climate and emergency responses
  17. 457
    “…Store-operated Ca(2+) entry (SOCE) is a mechanism that allows muscle fibers to recover external Ca(2+), which first enters the cytoplasm and then, via SERCA pump, also refills the depleted intracellular stores (i.e., the sarcoplasmic reticulum, SR). …”
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    Searching for Mechanisms Underlying the Assembly of Calcium Entry Units: The Role of Temperature and pH
  18. 458
    “…Finally, we describe the evidence that flecainide suppresses spontaneous Ca(2+) oscillations and fibro-adipogenic differentiation in ACM C-hMSCs by inhibiting constitutive SOCE.…”
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    Store-Operated Ca(2+) Entry as a Putative Target of Flecainide for the Treatment of Arrhythmogenic Cardiomyopathy
  19. 459
    “…In this review, we will outline the history of SOCE, the molecular players involved in this process, as well as the models that have been proposed to explain this critical mechanism in cellular physiology.…”
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    Regulation of store-operated calcium entry
  20. 460
    “…A decline in expression or activity of SERCA results in persistent store-operated calcium entry (SOCE). In cardiomyocytes as well as vascular smooth muscle cells (SMCs), SERCA2 acts as an important regulator of calcium cycling. …”
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    Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling
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