“…The attraction of CSEs to neutrophils was mediated by the SOCE/Akt/Src pathway.…”
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“…CEUs contain STIM1 and Orai1 proteins, the molecular machinery of store-operated Ca(2+) entry (SOCE). In extensor digitorum longus (EDL) fibers of wild-type (WT) mice, CEUs transiently assemble during acute exercise and disassemble several hours thereafter. …”
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“…This is manly linked to a constitutive activation of Store-Operated Ca(2+) Entry (SOCE), which leads to enhanced Ca(2+) release from the endoplasmic reticulum through inositol-1,4,5-trisphosphate receptors. …”
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“…BACKGROUND: Depletion of calcium (Ca(2+)) from the endoplasmic reticulum (ER) activates the ubiquitous store-operated Ca(2+) entry (SOCE) pathway which sustains long-term Ca(2+) signals and is critical for cellular functions. …”
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“…Moreover, siNOX4 transfection markedly reduced rhBMP4-induced elevation of TRPC1 and 6 proteins, basal [Ca(2+)](i) and SOCE. Furthermore, compared with control group (0.21±0.001), the proliferation of rhBMP4 treated cells was significantly enhanced (0.41±0.001) (P<0.01). …”
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“…CONCLUSION: Although secreted platelet 5-HT does not appear to play a crucial role in the development of reperfusion injury after stroke, it is essential to amplify the second phase of platelet activation through SOCE and plays an important role in thrombus stabilization.…”
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“…Furthermore, N. caninum-triggered NETosis depends on Ca(++) influx as well as neutrophil metabolism since both the inhibition of SOCE and of P2Y2-mediated ATP uptake diminished NET formation. …”
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“…In conclusion, lipophilic constituents of DEPs extracted by n-hexane and DCM seem to induce rapid AhR-dependent [Ca(2+)](i) increase in HMEC-1 endothelial cells, possibly involving both ROCE and SOCE-mediated mechanisms. The semi-lipophilic fraction extracted by DCM also caused an AhR-dependent reduction in global membrane order, which appeared to be connected to the [Ca(2+)](i) increase.…”
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“…In conclusion, exercise prevented improper accumulation of STIM1 and ORAI1 in TAs during aging, maintaining the capability of aged muscle to refill intracellular Ca(2+) stores via SOCE.…”
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“…In cell culture, SLC10A7 expression is negatively correlated with store-operated calcium entry (SOCE) via the plasma membrane. SLC10A7-deficient cells have significantly increased calcium influx after treatment with thapsigargin for depletion of ER calcium stores, whereas SLC10A7/RCAS overexpression limits calcium influx. …”
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“…ABSTRACT: Store operated Ca(2+) entry (SOCE) mediated by Orai1/2/3 channels is a highly regulated and ubiquitous Ca(2+) influx pathway. …”
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“…In both the presence and absence of androgen deprivation, nifedipine was found to have no impact on store release induced by thapsigargin (Tg) in 0mM Ca(2+) nor store operated calcium entry (SOCE) following the addition of 2mM Ca(2+). However, CACNA1D siRNA knockdown was able to reduce SOCE in PC3 cells. …”
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“…Upon release, the diffusing Ca(2+) has multiple fates: binds to troponin C thus activating the contractile machinery, binds to classical sarcoplasmic Ca(2+) buffers such as parvalbumin, adenosine triphosphate and, experimentally, fluorescent dyes, enters the mitochondria and the SR, or is recycled through the Na(+)/Ca(2+) exchanger and store-operated Ca(2+) entry (SOCE) mechanisms. To commemorate the 7(th) decade after being coined, we comprehensively and critically reviewed “old”, historical landmarks and well-established concepts, and blended them with recent advances to have a complete, quantitative-focused landscape of the ECC. …”
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“…METHODS: Cross-sectional surveys were carried out in Velingara (south Senegal) and Keur Soce (central Senegal) between September and October 2010. …”
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“…Since their discovery two decades ago, functional studies using junctophilin-deficient animals have provided a deep understanding of their roles in muscles and neurons, including excitation-contraction coupling, store-operated calcium entry (SOCE), and afterhyperpolarization (AHP). In this review, we highlight key findings from mouse, fly, and worm that support evolutionary conservation of junctophilins.…”
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“…Moreover, the change in SOCE was suppressed by btp-2, which is a non-selective inhibitor of Orai. …”
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“…These results suggest that H295R expresses a functional P2Y(1) purinergic receptor for intracellular Ca(2+)-mobilization, and that P2Y(1) is linked to SOCE-activation, leading to Ca(2+)-influx which might be necessary for glucocorticoid secretion.…”
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“…Aging also promotes the partial loss of store-operated Ca(2+) entry (SOCE), a Ca(2+) entry pathway involved in memory storage. …”
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“…These non-TCR/CD3-dependent Ca(2+) microdomains rely on d-myo-inositol 1,4,5-trisphosphate (IP(3)) signaling and subsequent store operated Ca(2+) entry (SOCE) via the ORAI/STIM system. The detailed molecular mechanism of adhesion-dependent Ca(2+) microdomain formation remains to be fully elucidated. …”
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