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“…Ca(2+) entry into many cell types including immune cells is triggered by depleting endoplasmic reticulum (ER) Ca(2+), a process termed store-operated Ca(2+) entry (SOCE). STIM1 is an ER Ca(2+) sensor. Upon Ca(2+) store depletion, STIM1 clusters at ER-plasma membrane junctions where it interacts with and gates Ca(2+)-permeable Orai1 ion channels. …”
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“…Store-operated Ca(2+) entry (SOCE) is an ubiquitous mechanism for Ca(2+) entry in eukaryotic cells. …”
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“…In this review, we are focusing on TRPC1, a member of the TRP protein superfamily and a potential modulator of store-operated Ca(2+) entry (SOCE) pathways. While TRPC1 is ubiquitously expressed in most tissues, its dysregulated activity may contribute to the hallmarks of various types of cancers, including breast cancer, pancreatic cancer, glioblastoma multiforme, lung cancer, hepatic cancer, multiple myeloma, and thyroid cancer. …”
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“…The common currency of epithelial differentiation and homeostasis is calcium, stored primarily in the endoplasmic reticulum, rationed according to need, and replenished from the extracellular milieu via store-operated calcium entry (SOCE). This currency is disbursed by the IP3 receptor in response to diverse extracellular signals. …”
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“…Orai1-mediated store-operated Ca(2+) entry (SOCE) is the primary mechanism underlying most of the non-excitable calcium influx into cells. …”
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“…Using total internal reflection fluorescence microscopy we found that cold causes STIM1 to aggregate with and activate ORAI1 ion channels, in a mechanism similar to that underlying store‐operated calcium entry (SOCE), but directly activated by cold and not by emptying of calcium stores. …”
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“…This MIP Timing Detector (MTD) will consist of a central barrel timing layer (BTL) based on L(Y)SO:Ce crystals read out with silicon photomultipliers (SiPMs) and two end-caps instrumented with radiation-tolerant low-gain avalanche detectors (LGADs). …”
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“…SAR appears to be important in a wide range of other physiological functions, such as Sarco-Endoplasmic Reticulum Calcium ATPase (SERCA) stabilization, Store-Operated-Calcium-Entry (SOCE) mechanisms, muscle fatigue resistance and muscle development. …”
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“…The STIM family of proteins plays a crucial role in a plethora of cellular functions through the regulation of store-operated Ca(2+) entry (SOCE) and, thus, intracellular calcium homeostasis. …”
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“…Tumors from patients with ESCC were found to display elevated expression of Orai1, a store-operated Ca(2+) entry (SOCE) channel, and the high expression of Orai1 was associated with poor overall and recurrence-free survival. …”
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“…This process termed store-operated Ca(2+) entry (SOCE) involves the ER Ca(2+) sensing molecule, STIM1, and a pore-forming plasma membrane protein, ORAI1. …”
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“…Here, studies on the roles of channel proteins that mediate extracellular Ca(2+) entry into skeletal muscle cells using skeletal myoblasts, myotubes, fibers, tissue, or skeletal muscle-originated cell lines are reviewed with special attention to the proposed functions of transient receptor potential canonical proteins (TRPCs) as store-operated Ca(2+) entry (SOCE) channels under normal conditions and the potential abnormal properties of TRPCs in muscle diseases such as Duchenne muscular dystrophy (DMD).…”
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“…Stromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca(2+) entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca(2+)), which is closely associated with tumor cell proliferation, metastasis, apoptosis, autophagy, metabolism and immune processes. …”
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“…To investigate the potential of inhibiting ion channel function with an antibody, we focused on Orai1, the pore subunit of the calcium channel responsible for store-operated calcium entry (SOCE) in T cells. Effector T cells are key drivers of autoimmune disease pathogenesis and calcium signaling is essential for T cell activation, proliferation, and cytokine production. …”
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“…Importantly, migration of PDAC cells was strongly suppressed by selective inhibition of IP(3)Rs and store-operated Ca(2+) entry (SOCE), indicating that these mechanisms are functionally required for migration.…”
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“…Using CHO K1 cell lines stably expressing a wild type human AAT (MAAT) and a disease-causing polymer-forming variant (ZAAT) and the truncated variant (NHK AAT), we measured basal intracellular free Ca(2+), its responses to thapsigargin (TG), an ER Ca(2+)-ATPase blocker, and store-operated Ca(2+)-entry (SOCE). Our fura2 based Ca(2+) measurements detected no differences between these 3 parameters in cell lines expressing MAAT and cell lines expressing ZAAT and NHK AAT mutants. …”
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“…Some of these channels have been reported to mediate background depolarizing currents, store-operated Ca(2+) entry (SOCE), electrical activity, Ca(2+) oscillations, gene transcription, cell-death, and insulin secretion in response to stimulation by glucose and GLP1. …”
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