Mostrando 561 - 580 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.12s Limitar resultados
  1. 561
    “…This mechanism contributes to the enhanced SOCE observed in triple-negative breast cancer cells. …”
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    The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation
  2. 562
    “…Orai1 is the major player in mediating store-operated calcium entry (SOCE) and regulates calcium homeostasis in non-excitable cells. …”
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    Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth
  3. 563
    “…In addition, these mutations exhibit a novel phenotype manifested as a constitutively open channel, which inappropriately gates SOCE in the absence of stimulation.…”
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    Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca(2+) channels and activation of store-operated Ca(2+) entry
  4. 564
    por Kim, Yoon-Jung
    Publicado 2023
    “…In this review, we seek to elucidate the potential of GPCRs, the inositol 1,4,5-trisphosphate receptor (IP(3)R), store-operated Ca(2+) entry (SOCE), and AQP5, which are essential for salivation, as cellular targets in the etiology of xerostomia.…”
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    Xerostomia and Its Cellular Targets
  5. 565
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    Recommendations for the COVID-19 Response at the National Level Based on Lessons Learned from the Ebola Virus Disease Outbreak in the Democratic Republic of the Congo
  6. 566
    “…Mechanically, PRRSV infection induces endoplasmic reticulum (ER) stress and forms a closed ER–plasma membrane (PM) contacts, resulting the opening of store operated calcium entry (SOCE) channel and causing the ER to take up extracellular Ca(2+), which is then released into the cytoplasm by inositol trisphosphate receptor (IP3R) channel. …”
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    Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication
  7. 567
    “…A number of known molecular components involved in Ca(2+) influx pathways, including stromal interaction molecule (STIM)/Orai-mediated store-operated Ca(2+) entry (SOCE) and the Ca(2+)-permeable transient receptor potential (TRP) channels, have been implicated in cancer cell migration and tumor metastasis. …”
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    Remodeling of calcium signaling in tumor progression
  8. 568
    “…In Drosophila melanogaster, it is known that neuronal IP(3) receptor mediated Ca(2+) signaling and store-operated Ca(2+) entry (SOCE) are required for air-puff stimulated adult flight. …”
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    A Genetic RNAi Screen for IP(3)/Ca(2+) Coupled GPCRs in Drosophila Identifies the PdfR as a Regulator of Insect Flight
  9. 569
    “…Orexin-A-induced ERK1/2 phosphorylation and astrocytes migration are Ca(2+)-dependent, since they could be inhibited by either chelating the extracellular Ca(2+) or blocking the pathway of store-operated calcium entry (SOCE). Furthermore, both non-selective protein kinase C (PKC) inhibitor and PKCα selective inhibitor, but not PKCδ inhibitor, prevented the increase in ERK1/2 phosphorylation and the migration of astrocytes, indicating that the Ca(2+)-dependent PKCα acts as the downstream of the OX1R activation and mediates the orexin-A-induced increase in ERK1/2 phosphorylation and cell migration. …”
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    Orexin-A Promotes Cell Migration in Cultured Rat Astrocytes via Ca(2+)-Dependent PKCα and ERK1/2 Signals
  10. 570
    “…We documented the formation of endocytic vacuoles in response to store-operated Ca(2+) entry (SOCE) induced by thapsigargin [TG; inhibitor of sarcoplasmic/endoplasmic reticulum (ER) Ca(2+) pumps] and observed strong inhibition of TG-induced vacuole formation by GSK-7975A. …”
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    The role of Ca(2+) influx in endocytic vacuole formation in pancreatic acinar cells
  11. 571
    “…Previous studies have revealed the importance of the Ca(2+) sensor STIM1 and store-operated Ca(2+)-entry (SOCE) for Fcγ-receptor activation and IgG-induced inflammation. …”
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    Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation
  12. 572
    “…As a case study, we applied this pipeline to the STIMATE (TMEM110) gene family, which has recently been reported to play an important role in store-operated Ca(2+) entry (SOCE) mediated by ORAI and STIM proteins. We inferred their phylogenetic trees in 69 sequenced chordate genomes. …”
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    Integrated pipeline for inferring the evolutionary history of a gene family embedded in the species tree: a case study on the STIMATE gene family
  13. 573
    “…This review summarizes the current knowledge of the complex role of Store Operated Calcium Entry (SOCE) pathways and related proteins in the function of cardiac, skeletal, and vascular smooth muscle cells.…”
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    The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells
  14. 574
    “…In this study, we show that blocking store-operated calcium entry (SOCE) with 2-aminoethoxydiphenylborane (2APB) reduces cell migration but, paradoxically, increases the level of TGF-β dependent Snai1 gene activation. …”
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    The calcium channel proteins ORAI3 and STIM1 mediate TGF-β induced Snai1 expression
  15. 575
    “…During an immune response, the engagement of T-cell and B-cell antigen receptors induces a decrease in the intracellular Ca(2+) store and then activates store-operated Ca(2+) entry (SOCE) to raise the intracellular Ca(2+) concentration, which is mediated by the Ca(2+) release-activated Ca(2+) (CRAC) channels. …”
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    The Role of Calcium–Calcineurin–NFAT Signaling Pathway in Health and Autoimmune Diseases
  16. 576
    “…This study was undertaken to test two therapies for acute kidney injury (AKI) prevention, IGF-1, which is renal protective, and BTP-2, which is a calcium entry (SOCE) inhibitor. We utilized lipopolysaccharide (LPS) IP, as a systemic model of AKI and studied in five groups of animals. …”
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    IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury
  17. 577
    “…We further show that sCaLTs are primarily generated through a combination of Ca(2+) influx through store-operated Ca(2+) entry (SOCE) and Ca(2+) release from internal Ca(2+) stores. …”
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    Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca(2+) Entry and Release
  18. 578
    “…Here we show that J147 and its molecular target, ATP synthase, regulate the maintenance of store-operated calcium entry (SOCE) and cell death during acute neurotoxicity.…”
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    Targeting of intracellular Ca(2+) stores as a therapeutic strategy against age-related neurotoxicities
  19. 579
    “…Stromal interaction molecule (STIM) proteins play a crucial role in store-operated calcium entry (SOCE) as endoplasmic reticulum Ca(2+) sensors. In neurons, STIM2 was shown to have distinct functions from STIM1. …”
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    Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae
  20. 580
    “…Naltriben and mibefradil both evoked Ca(2+) influx, which was further enhanced by the acidic intracellular conditions. The SOCE inhibitor BTP2 blocked Ca(2+) entry induced by naltriben but not by mibefradil. …”
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    TRPM7-Mediated Calcium Transport in HAT-7 Ameloblasts
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