Mostrando 41 - 60 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.18s Limitar resultados
  1. 41
    “…Instead of its known function as an L-type calcium channel blocker, we found that amlodipine is able to activate Ca(2+) entry by enhancing store-operated Ca(2+) entry (SOCE). Amlodipine as well as approaches that cause store depletion and activate SOCE trigger phosphorylation and activation of Lats1/2, which in turn phosphorylate YAP/TAZ and prevent their accumulation in the cell nucleus. …”
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    Induction of store operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ
  2. 42
    “…Caveolin-1 belongs to one of the key regulators of the intracellular calcium homeostasis in PASMCs, which can regulate the store-operated calcium entry (SOCE). However, the effects of BTZ on Caveolin-1 remain unclear. …”
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    Bortezomib Inhibits Hypoxia-Induced Proliferation by Suppressing Caveolin-1/SOCE/[Ca(2+)](i) Signaling Axis in Human PASMCs
  3. 43
    “…We report the complete genome sequence of Stutzerimonas stutzeri strain SOCE 002, obtained from Illumina and Oxford Nanopore sequencing. …”
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    Complete Genome Sequence of Stutzerimonas stutzeri Strain SOCE 002, a Marine Bacterium Isolated from the Surface Seawater of Dapeng Bay
  4. 44
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    Scintillation properties of Ca co-doped L(Y)SO:Ce between 193 K and 373 K for TOF-PET/MRI
  5. 45
    “…These data reveal that increasing intracellular tau can upregulate C/EBPβ‐TRPC1‐SOCE signaling and thus disrupt phosphorylating system, which together aggravates tau pathologies leading to a chronic neurodegeneration.…”
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    Tau‐induced upregulation of C/EBPβ‐TRPC1‐SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration
  6. 46
    “…Mechanistically, transcriptome and metabolite analyses reveal that treatment with BTP‐2 significantly downregulate SOCE‐calcineurin‐nuclear factor of activated T‐cells (NFAT) and glycolysis pathways. …”
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    Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways
  7. 47
    Publicado 2020
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    Correction: The deregulation of STIM1 and store operative calcium entry (SOCE) impaired aortic smooth muscle cells contractility in aortic medial degeneration
  8. 48
    “…In addition, E. bovis-induced NETosis was found to be Ca(2+)-dependent since the inhibition of store-operated calcium entry (SOCE) significantly diminished NET. Furthermore, NADPH oxidase, neutrophil elastase (NE) and myeloperoxidase (MPO) were confirmed as key molecules in sporozoite-triggered NETosis, as inhibition thereof blocked parasite-triggered NET. …”
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    Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent
  9. 49
    “…Since TNF-α production is known to be associated with intracellular Ca(2+) elevation, we examined the effect of store-operated Ca(2+) entry (SOCE) inhibitors on TNF-α production in O. tsutsugamushi-infected macrophages. …”
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    A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages
  10. 50
    “…Collectively, we conclude that nucleotides activate P2Y6 receptors to suppress GC growth through a novel SOCE/Ca(2+)/β-catenin-mediated anti-proliferation of GC cells, which is different from the canonical SOCE/Ca(2+)-induced apoptosis in other tumors.…”
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    Anti-proliferative Effects of Nucleotides on Gastric Cancer via a Novel P2Y6/SOCE/Ca(2+)/β-catenin Pathway
  11. 51
    “…From a series of (1R, 1S)-1[β-(phenylalkoxy)-(phenetyl)]-1H-pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca(2+) release and store-operated Ca(2+) entry (SOCE) (IC(50) 25 μM) on the PLP-B lymphocyte cell line. …”
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    Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors
  12. 52
    “…Functional studies on patient-derived cells revealed that CRAC channelopathy mutations impair SOCE and extracellular Ca(2+) influx, while TAM/STRMK mutations induce excessive Ca(2+) entry through SOCE over-activation. …”
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    STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases
  13. 53
    “…In this study, we investigated the potential protective effect of SKF-96365, a non-specific inhibitor of SOCE (store-operated calcium entry), on MPP(+) induced cytotoxicity in PC12 cells. …”
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    Protective Effects of SKF-96365, a Non-Specific Inhibitor of SOCE, against MPP(+)-Induced Cytotoxicity in PC12 Cells: Potential Role of Homer1
  14. 54
    “…Here, we show that NO1, but not other σ2R/TMEM97 ligands, reduced SOCE in MDA-MB-231 cells. Similarly, TMEM97 silencing in MDA-MB-231 cells also impaired SOCE. …”
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    NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines
  15. 55
    “…We conclude that M. fortuitum-induced persistent SOCE signaling leads to mtROS production, which in turn activates the TNF-α/caspase-8 axis culminating in HKM apoptosis and bacterial clearance.…”
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    mtROS Induced via TLR-2-SOCE Signaling Plays Proapoptotic and Bactericidal Role in Mycobacterium fortuitum-Infected Head Kidney Macrophages of Clarias gariepinus
  16. 56
    “…We have discovered 2-APB derivatives that block SOCE at low concentrations, at which 2-APB usually enhances SOCE.…”
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    Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells
  17. 57
    “…Our results therefore suggest ORAI1/SOCE as potential markers of AML progression and drug resistance apparition.…”
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    Involvement of ORAI1/SOCE in Human AML Cell Lines and Primary Cells According to ABCB1 Activity, LSC Compartment and Potential Resistance to Ara-C Exposure
  18. 58
    “…Furthermore, Phemindole mediated Store Operated Calcium Entry (SOCE) retardation favored inactivation of STIM1 and henceforth activated ER stress to induce apoptosis in TNBC cells. …”
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    Phemindole, a Synthetic Di-indole Derivative Maneuvers the Store Operated Calcium Entry (SOCE) to Induce Potent Anti-Carcinogenic Activity in Human Triple Negative Breast Cancer Cells
  19. 59
    “…To dissect SOCE from ROCE in BV2 cells, we applied high-resolution multiphoton Ca(2+) imaging. …”
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    Store-Operated Ca(2+) Entry (SOCE) and Purinergic Receptor-Mediated Ca(2+) Homeostasis in Murine bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation
  20. 60
    “…Our data show that, in a positive feedback loop SOCE activates both Akt pathway and SK3 channel activity which lead to SOCE amplification. …”
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    SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline
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