Mostrando 601 - 620 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.34s Limitar resultados
  1. 601
    “…Using mice with T cell-specific deletion of MCU, we here show that genetic inactivation of mitochondrial Ca(2+) uptake increased cytosolic Ca(2+) levels following antigen receptor stimulation and store-operated Ca(2+) entry (SOCE). However, ablation of MCU and the elevation of cytosolic Ca(2+) did not affect mitochondrial respiration, differentiation and effector function of inflammatory and regulatory T cell subsets in vitro and in animal models of T cell-mediated autoimmunity and viral infection. …”
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  2. 602
    “…BACKGROUND/PURPOSE: Return of Ca(2+) to endoplasmic reticulum is mediated by Orai/STIM-mediated store-operated Ca(2+) entry (SOCE) channel. We aimed to investigate Orai1 and STIM1 expressions in human oral carcinogenesis. …”
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  7. 607
    “…HEK293 cells that stably express human STIM1 and Orai1, components of the store-operated calcium entry (SOCE) machinery, gave a much higher RLA by stimulation with thapsigargin, an inhibitor of sarcoplasmic/endoplamic reticulum Ca(2+)-ATPase (SERCA). …”
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  8. 608
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  10. 610
    “…Under conditions of local or global depletion of SR Ca(2+) stores, store-operated Ca(2+) entry (SOCE) provides an additional source of Ca(2+) that originates from the extracellular space. …”
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  11. 611
    “…ROS elicit endothelial Ca(2+) signals by regulating inositol-1,4,5-trisphosphate receptors, sarco-endoplasmic reticulum Ca(2+)-ATPase 2B, two-pore channels, store-operated Ca(2+) entry (SOCE), and multiple isoforms of transient receptor potential (TRP) channels. …”
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  12. 612
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  14. 614
    “…NK cell stimulation by ALG depended on the influx of extracellular Ca(2+) via the SOCE Ca(2+) permeable plasma membrane channels. ALG-CM also activated NK cell cytokine production of IFN-γ and TNF-α through a partly Ca(2+)-independent mechanism. …”
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  15. 615
    “…Stromal interaction molecule 1 (Stim1) functions as a sensor of Ca(2+) within stores and plays an essential role in the activation of store-operated Ca(2+) entry (SOCE). Although lowering Stim1 levels reduces store-operated Ca(2+) entry and inhibits intestinal epithelial repair after wounding, the mechanisms that control Stim1 expression remain unknown. …”
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  16. 616
    “…Thrombin treatment was associated with a rise in intracellular [Ca(2+)] and enhanced store‐operated calcium entry (SOCE). These effects lead to enhanced proliferation, which is more dramatic in both IPAH and CTEPH PASMC. …”
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  17. 617
    “…Store-operated Ca(2+) entry (SOCE) is the predominant Ca(2+) entry mechanism in most cancer cells, and STIM1 is the endoplasmic reticulum (ER) Ca(2+) sensor for store-operated channels (SOC). …”
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  18. 618
    “…METHODS: Two cohorts of children aged four to six weeks were recruited in Banfora, Burkina and Keur Soce, Senegal and followed up for two years. Malaria infections were detected by light microscopic examination of blood smears collected at active and passive case detection visits. …”
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  19. 619
    “…Moreover, we demonstrated that pretreatment with Que, neutralized the up-regulation of STIM1 induced by LPS and declined both LPS and thapsigargin (Tg)-induced store-operated Ca(2+) entry (SOCE). Finally, we found that pretreatment with Que significantly reduced the translocation of nuclear factor kappa B (NF-κB) p65 subunit from cytoplasm to nuclei in LPS-activated primary microglial cells. …”
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  20. 620
    “…Interestingly, platelets from STC2(−/−) mice exhibit attenuated interaction between STIM1 and Orai1 in response to Thr, thus suggesting that STC2 is required for Thr-evoked STIM1-Orai1 interaction and the subsequent store-operated Ca(2+) entry (SOCE). We have further assessed possible changes in the expression of the most relevant channels involved in non-capacitative Ca(2+) entry in platelets. …”
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