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601por Wu, Hao, Brand, Benjamin, Eckstein, Miriam, Hochrein, Sophia M., Shumanska, Magdalena, Dudek, Jan, Nickel, Alexander, Maack, Christoph, Bogeski, Ivan, Vaeth, Martin“…Using mice with T cell-specific deletion of MCU, we here show that genetic inactivation of mitochondrial Ca(2+) uptake increased cytosolic Ca(2+) levels following antigen receptor stimulation and store-operated Ca(2+) entry (SOCE). However, ablation of MCU and the elevation of cytosolic Ca(2+) did not affect mitochondrial respiration, differentiation and effector function of inflammatory and regulatory T cell subsets in vitro and in animal models of T cell-mediated autoimmunity and viral infection. …”
Publicado 2021
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602por Wang, Yen-Yun, Wang, Wen-Chen, Su, Chiang-Wei, Hsu, Ching-Wei, Yuan, Shyng-Shiou, Chen, Yuk-Kwan“…BACKGROUND/PURPOSE: Return of Ca(2+) to endoplasmic reticulum is mediated by Orai/STIM-mediated store-operated Ca(2+) entry (SOCE) channel. We aimed to investigate Orai1 and STIM1 expressions in human oral carcinogenesis. …”
Publicado 2022
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603por Chang, Yan, Funk, Marah, Roy, Souvik, Stephenson, Elizabeth, Choi, Sangyong, Kojouharov, Hristo V., Chen, Benito, Pan, Zui“…We previously reported that store-operated Ca(2+) entry (SOCE) blockers, such as RP4010, are promising antitumor drugs for esophageal cancer. …”
Publicado 2022
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604por Schnipper, Julie, Kouba, Sana, Hague, Frédéric, Girault, Alban, Rybarczyk, Pierre, Telliez, Marie-Sophie, Guénin, Stéphanie, Tebbakha, Riad, Sevestre, Henri, Ahidouch, Ahmed, Pedersen, Stine Falsig, Ouadid-Ahidouch, Halima“…In addition, the KD of TRPC1 neither affected Ca(2+) influx nor store-operated Ca(2+) entry (SOCE) and reduced cell proliferation independently of extracellular calcium. …”
Publicado 2022
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605por Hamblion, Esther, Saad, Neil J., Greene-Cramer, Blanche, Awofisayo-Okuyelu, Adedoyin, Selenic Minet, Dubravka, Smirnova, Anastasia, Engedashet Tahelew, Etsub, Kaasik-Aaslav, Kaja, Alexandrova Ezerska, Lidia, Lata, Harsh, Allain Ioos, Sophie, Peron, Emilie, Abdelmalik, Philip, Perez-Gutierrez, Enrique, Almiron, Maria, Kato, Masaya, Babu, Amarnath, Matsui, Tamano, Biaukula, Viema, Nabeth, Pierre, Corpuz, Aura, Pukkila, Jukka, Cheng, Ka-Yeung, Impouma, Benido, Koua, Etien, Mahamud, Abdi, Barboza, Phillipe, Socé Fall, Ibrahima, Morgan, OliverEnlace del recurso
Publicado 2023
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607“…HEK293 cells that stably express human STIM1 and Orai1, components of the store-operated calcium entry (SOCE) machinery, gave a much higher RLA by stimulation with thapsigargin, an inhibitor of sarcoplasmic/endoplamic reticulum Ca(2+)-ATPase (SERCA). …”
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609por Mbala-Kingebeni, Placide, Pratt, Catherine, Ruffin, Mbusa Mutafali, Pauthner, Matthias G., Bile, Faustin, Nkuba Ndaye, Antoine, Black, Allison, Kinganda Lusamaki, Eddy, Faye, Martin, Aziza, Amuri, Diagne, Moussa M, Mukadi, Daniel, White, Bailey, Hadfield, James, Gangavarapu, Karthik, Bisento, Nella, Kazadi, Donatien, Nsunda, Bibiche, Akonga, Marceline, Tshiani, Olivier, Misasi, John, Ploquin, Aurelie, Epaso, Victor, Sana Paka, Emilia, N’kasar, Yannick Tutu Tshia, Mambu, Fabrice, Edidi, Francois, Matondo, Meris, Bula Bula, Junior, Diallo, Boubacar, Keita, Mory, Belizaire, Marie Roseline Darnycka, Fall, Ibrahima Soce, Yam, Abdoulaye, Sabue, Mulangu, Rimion, Anne W., Salfati, Elias, Torkamani, Ali, Suchard, Marc A., Crozier, Ian, Hensley, Lisa, Rambaut, Andrew, Faye, Ousmane, Sall, Amadou, Sullivan, Nancy J., Bedford, Trevor, Andersen, Kristian G., Wiley, Michael R., Ahuka-Mundeke, Steve, Muyembe Tamfum, Jean-JacquesEnlace del recurso
Publicado 2021
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610“…Under conditions of local or global depletion of SR Ca(2+) stores, store-operated Ca(2+) entry (SOCE) provides an additional source of Ca(2+) that originates from the extracellular space. …”
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611“…ROS elicit endothelial Ca(2+) signals by regulating inositol-1,4,5-trisphosphate receptors, sarco-endoplasmic reticulum Ca(2+)-ATPase 2B, two-pore channels, store-operated Ca(2+) entry (SOCE), and multiple isoforms of transient receptor potential (TRP) channels. …”
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614por Adib, Yara, Boy, Maxime, Serror, Kevin, Dulphy, Nicolas, des Courtils, Céline, Duciel, Laura, Boccara, David, Mimoun, Maurice, Samardzic, Marina, Bagot, Martine, Bensussan, Armand, Michel, Laurence“…NK cell stimulation by ALG depended on the influx of extracellular Ca(2+) via the SOCE Ca(2+) permeable plasma membrane channels. ALG-CM also activated NK cell cytokine production of IFN-γ and TNF-α through a partly Ca(2+)-independent mechanism. …”
Publicado 2023
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615por Zhuang, Ran, Rao, Jaladanki N., Zou, Tongtong, Liu, Lan, Xiao, Lan, Cao, Shan, Hansraj, Natasha Z., Gorospe, Myriam, Wang, Jian-Ying“…Stromal interaction molecule 1 (Stim1) functions as a sensor of Ca(2+) within stores and plays an essential role in the activation of store-operated Ca(2+) entry (SOCE). Although lowering Stim1 levels reduces store-operated Ca(2+) entry and inhibits intestinal epithelial repair after wounding, the mechanisms that control Stim1 expression remain unknown. …”
Publicado 2013
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616por Ogawa, Aiko, Firth, Amy L., Ariyasu, Sanae, Yamadori, Ichiro, Matsubara, Hiromi, Song, Shanshan, Fraidenburg, Dustin R., Yuan, Jason X.‐J.“…Thrombin treatment was associated with a rise in intracellular [Ca(2+)] and enhanced store‐operated calcium entry (SOCE). These effects lead to enhanced proliferation, which is more dramatic in both IPAH and CTEPH PASMC. …”
Publicado 2013
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617por Wang, Jaw-Yuan, Sun, Jianwei, Huang, Ming-Yii, Wang, Yu-Shiuan, Hou, Ming-Feng, Sun, Yan, He, Huifang, Krishna, Niveditha, Chiu, Siou-Jin, Lin, Shengchen, Yang, Shengyu, Chang, Wei-Chiao“…Store-operated Ca(2+) entry (SOCE) is the predominant Ca(2+) entry mechanism in most cancer cells, and STIM1 is the endoplasmic reticulum (ER) Ca(2+) sensor for store-operated channels (SOC). …”
Publicado 2014
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618por Kangoye, David Tiga, Mensah, Victorine Atanase, Murungi, Linda Muthoni, Nkumama, Irene, Nebie, Issa, Marsh, Kevin, Cisse, Badara, Bejon, Philip, Osier, Faith Hope Among’in, Sirima, Sodiomon Bienvenu“…METHODS: Two cohorts of children aged four to six weeks were recruited in Banfora, Burkina and Keur Soce, Senegal and followed up for two years. Malaria infections were detected by light microscopic examination of blood smears collected at active and passive case detection visits. …”
Publicado 2016
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619por Wang, Hanzhi, Liu, Shubao, Tian, Yanping, Wu, Xiyan, He, Yangtao, Li, Chengren, Namaka, Michael, Kong, Jiming, Li, Hongli, Xiao, Lan“…Moreover, we demonstrated that pretreatment with Que, neutralized the up-regulation of STIM1 induced by LPS and declined both LPS and thapsigargin (Tg)-induced store-operated Ca(2+) entry (SOCE). Finally, we found that pretreatment with Que significantly reduced the translocation of nuclear factor kappa B (NF-κB) p65 subunit from cytoplasm to nuclei in LPS-activated primary microglial cells. …”
Publicado 2015
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620por López, Esther, Gómez-Gordo, L., Cantonero, Carlos, Bermejo, Nuria, Pérez-Gómez, Jorge, Granados, María P., Salido, Gines M., Rosado Dionisio, Juan A., Redondo Liberal, Pedro C.“…Interestingly, platelets from STC2(−/−) mice exhibit attenuated interaction between STIM1 and Orai1 in response to Thr, thus suggesting that STC2 is required for Thr-evoked STIM1-Orai1 interaction and the subsequent store-operated Ca(2+) entry (SOCE). We have further assessed possible changes in the expression of the most relevant channels involved in non-capacitative Ca(2+) entry in platelets. …”
Publicado 2018
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