“…BACKGROUND: The endoplasmic reticulum (ER) Ca(2+) sensor, stromal interaction molecule1 (STIM1) activates the plasma membrane (PM) channel Orai1 in order to mediate store-operated Ca(2+) entry (SOCE) in response to ER store depletion. Enhanced expression of STIM1 in cancer tissue has been associated with poor patient prognosis. …”
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“…SLC10A7 protein expression was negatively correlated with store-operated calcium entry (SOCE) via the plasma membrane. Whereas SLC10A7 knockout HAP1 cells showed significantly increased calcium influx after thapsigargin, ionomycin and ATP/carbachol treatment, SLC10A7 overexpression reduced this calcium influx. …”
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“…Of note, OR2W3-evoked [Ca(2+)](i) mobilization and ASM relaxation required Ca(2+) flux through the store-operated calcium entry (SOCE) pathway and accompanied plasma membrane depolarization. …”
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“…Microdomains formed by proteins of endoplasmic reticulum and plasma membrane play a key role in store-operated Ca(2+) entry (SOCE). Ca(2+) release through inositol 1,4,5-trisphosphate receptor (IP(3)R) and subsequent Ca(2+) store depletion activate STIM (stromal interaction molecules) proteins, sensors of intraluminal Ca(2+), which, in turn, open the Orai channels in plasma membrane. …”
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“…Store-operated Ca(2+) entry (SOCE) is a ubiquitous Ca2+ signaling modality mediated by Orai Ca(2+) channels at the plasma membrane (PM) and the endoplasmic reticulum (ER) Ca(2+) sensors STIM1/2. …”
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“…We have used optical imaging and whole-cell voltage clamp to measure the contribution of store-operated Ca(2+) entry (SOCE) to Ca(2+) homeostasis and its role in regulation of neurotransmission at cone synapses. …”
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“…CSQ knock-out mice muscles still preserve a near-normal contractile behavior, but it is unclear whether this is caused by additional SR calcium buffering or a significant contribution of calcium entry from extracellular space, via stored-operated calcium entry (SOCE). The model enabled quantitative assessment of these two scenarios by comparison to measurements of local calcium in the cytosol, the SR and the mitochondria. …”
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“…The expression specificity as well as the functional operation of the ER/SR-targeted ChRGR (ChRGR(ER)) was evaluated using mouse skeletal myoblasts (C2C12): (1) the ChRGR(ER) co-localized with the ER-marker KDEL; (2) no membrane current was generated by light under whole-cell clamp of cells expressing ChRGR(ER); (3) an increase of fluorometric Ca(2+) was evoked by the optical stimulation (OS) in the cells expressing ChRGR(ER) in a manner independent on the extracellular Ca(2+) concentration ([Ca(2+)](o)); (4) the ΔF/F(0) was sensitive to the inhibitor of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) and (5) the store-operated Ca(2+) entry (SOCE) was induced by the OS in the ChRGR(ER)-expressing cells. …”
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“…The release of endoplasmic reticulum (ER) Ca(2+) stores by toxins (such as bile acids or fatty acid ethyl esters (FAEEs)) or increased intrapancreatic pressure activates the influx of extracellular Ca(2+) via the Orai1 Ca(2+) channel, a process known as store-operated Ca(2+) entry (SOCE). Intracellular Ca(2+) overload can lead to premature activation of trypsinogen in pancreatic acinar cells and impaired fluid and HCO(3)(-) secretion in ductal cells. …”
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“…However, NOX2 absence does not counteract the cytokine effects in ER Ca(2+) depletion, Store-Operated Calcium Entry (SOCE) increase and ER stress. Instead, the activation of ER stress precedes H(2)O(2) production. …”
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“…Powerful functional compensations ensue: activation of SOCE that increases [Ca(2+)](cyto); increased SERCA1 activity, which limits the decrease in [Ca(2+)](SR) and a restoration of SR calcium storage of unknown substrate. …”
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“…Store-operated calcium (Ca(2+)) entry (SOCE) can be mediated by two novel proteins, STIM/Orai. …”
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“…To test whether overexpression of the plasma membrane Ca(2+) channel is sufficient to explain the kinetic information, we adapted a previously published computational model by Maurya and Subramaniam to include additional details on the store-operated calcium entry (SOCE) process to recapitulate Ca(2+) dynamics after T cell receptor stimulation. …”
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“…Moreover, the amplitude of the store-operated Ca(2+) entry (SOCE), induced by store depletion using a SERCA inhibitor, was significantly greater in PASMC from hyperoxic pups. …”
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“…Using Neonatal Rat Ventricular Myocytes (NRVM) we demonstrated that Ucn-2 blunted I/R-induced Store Operated Ca(2+) Entry (SOCE), decreased the expression of TRPC5 and Orai1 as well as their interaction in reperfusion. …”
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“…Children and adult patients attending Keur Socé health post for signs suggestive of acute respiratory infection were enrolled after providing inform consent. …”
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