Mostrando 641 - 660 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 1.22s Limitar resultados
  1. 641
    “…Calcium ions cannot be produced in the cells and are dynamically fluxed among extracellular calcium pools, intracellular calcium storages and cytosolic calcium signals, namely calcium homeostasis, raising a possibility that calcium ions released from bone during bone metastasis would further enhance bone metastasis and aggravate tumor progression via the vicious cycle due to abnormal calcium homeostasis in breast cancer cells, osteoclasts and osteoblasts. TRPs, VGCCs, SOCE, and P2Xs are four major calcium channels/routes mediating extracellular calcium entry and affect calcium homeostasis. …”
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  2. 642
    “…Blocking either luminal Ca(2+) entry via the voltage-gated calcium channels (VGCC) or endoplasmic reticulum (ER) release via inositol 1,4,5-triphosphate receptor (IP(3)R) and ryanodine receptor (RyR) attenuated the Gln-induced ileal I ( sc ), Likewise, blocking serosal Ca(2+) entry via the store-operated Ca(2+) entry (SOCE), TRPV1/2 channels, and Na(+)/Ca(2+) exchangers (NCX) attenuated the Gln-induced ileal I ( sc ). …”
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  3. 643
    “…The intracellular calcium ion concentration was detected using fluorescence microscopy and a full-wavelength multifunctional microplate reader, and the expression of SOCE-related genes and STIM1/ORAI1 proteins was detected using PCR and WB. …”
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  4. 644
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  6. 646
    “…CONCLUSIONS AND IMPLICATIONS: Ca(2+) signaling plays a critical role in intestinal ion secretion via CRAC/Orai-mediated SOCE mechanism on the serosal side of epithelium. …”
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  7. 647
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  11. 651
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  13. 653
    “…Store-operated calcium entry (SOCE) has been described in adult and neonatal murine cardiomyocytes, and Orai1 proteins act as crucial ion-conducting constituents of this calcium entry pathway that can be engaged not only by passive Ca(2+) store depletion but also by neurohumoral stimuli such as angiotensin-II. …”
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  14. 654
  15. 655
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  18. 658
    “…The overexpression of the Orai1 channel inhibits SOCE when using the Ca(2+) readdition protocol. However, we found that HeLa cells overexpressing the Orai1 channel displayed enhanced Ca(2+) entry and a limited ER depletion in response to the combination of ATP and thapsigargin (TG) in the presence of external Ca(2+). …”
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  19. 659
    “…The store-operated calcium entry (SOCE) blocker, MRS1845, attenuated the WIN55212-2-stimulated increase in [Ca(2+)](i) at both levels of eCa(2+). …”
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  20. 660
    “…Increasing evidence indicates that high expression of stromal interaction molecule 1 (STIM1)-mediated store-operated calcium entry (SOCE) significantly activates the calcium (Ca(2+)) signaling pathway and is involved in multiple steps of bone metastasis in PCa. …”
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