Mostrando 81 - 100 Resultados de 703 Para Buscar '"Socing"', tiempo de consulta: 0.14s Limitar resultados
  1. 81
    “…Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca(2+)) load. …”
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    Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes
  2. 82
    “…SOCE (Store-Operated Calcium Entry) is the main mechanism by which external Ca(2+) enters into non-excitable cells after endoplasmic reticulum emptying. …”
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    Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase
  3. 83
    “…As a result, it abolished the functional coupling between STIM1 and Orai1, diminishing SOCE signals. Overall, our findings identified a new SOCE inhibitor celastrol that suppresses psoriasis, suggesting that SOCE pathway may serve as a new druggable target for treating psoriasis.…”
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    Celastrol inhibits store operated calcium entry and suppresses psoriasis
  4. 84
    “…Mitochondria contribute to cell signaling by controlling store-operated Ca(2+) entry (SOCE). SOCE is activated by Ca(2+) release from the endoplasmic reticulum (ER), whereupon stromal interacting molecule 1 (STIM1) forms oligomers, redistributes to ER–plasma-membrane junctions and opens plasma membrane Ca(2+) channels. …”
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    IP(3)-mediated STIM1 oligomerization requires intact mitochondrial Ca(2+) uptake
  5. 85
    por Papanikolaou, M., Lewis, A., Butt, A. M.
    Publicado 2017
    “…Replenishment of ER Ca(2+) stores relies on store-operated calcium entry (SOCE). However, despite the importance of calcium signalling in glial cells, little is known about their mechanisms of SOCE. …”
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    Store-operated calcium entry is essential for glial calcium signalling in CNS white matter
  6. 86
    “…Store‐operated Ca(2+) entry (SOCE) is indispensable for intracellular Ca(2+) homeostasis in skeletal muscle, and constitutive activation of SOCE causes tubular aggregate myopathy (TAM). …”
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    Antioxidants restore store‐operated Ca(2+) entry in patient‐iPSC‐derived myotubes with tubular aggregate myopathy‐associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein
  7. 87
    “…SOCE participates in regulating a number of physiological processes including cell proliferation and migration while SOCE dysregulation has been linked with pathophysiological conditions such as inflammation and cancer. …”
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    Blockade of store-operated calcium entry sensitizes breast cancer cells to cisplatin therapy via modulating inflammatory response
  8. 88
    por Czeredys, Magdalena
    Publicado 2020
    “…Recent research has shown that one of the major Ca(2+) signaling pathways, store-operated Ca(2+) entry (SOCE), is significantly elevated in HD. SOCE refers to Ca(2+) flow into cells in response to the depletion of endoplasmic reticulum Ca(2+) stores. …”
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    Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
  9. 89
    “…Stromal interaction molecular 1 (STIM1) is the necessary component of SOCE. In this study, we focus on to examine the regulatory mechanism of SOCE on DIM-induced death in gastric cancer. …”
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    3,3'-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry
  10. 90
    “…Background: Voluntary therapeutic interventions to reduce unwanted same-sex sexuality are collectively known as sexual orientation change efforts (SOCE).  Currently almost all evidence addressing the contested question whether SOCE is effective or safe consists of anecdotes or very small sample qualitative studies of persons who currently identify as sexual minority and thus by definition failed to change.  …”
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    Efficacy and risk of sexual orientation change efforts: a retrospective analysis of 125 exposed men
  11. 91
    “…Store-operated calcium entry (SOCE), a major mode of extracellular calcium entry, plays roles in a variety of cell activities. …”
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    Inhibition of Store-Operated Calcium Entry Protects Endothelial Progenitor Cells from H(2)O(2)-Induced Apoptosis
  12. 92
    por Hammad, Ayat S., Machaca, Khaled
    Publicado 2021
    “…Therefore, much remains to be learned regarding the role and regulation of SOCE in migrating cells.…”
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    Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
  13. 93
    “…Ingenuity Pathway Analysis (IPA) indicated that the SSc pathological pathways were closely associated with store-operated Ca(2+) entry (SOCE)-regulated signals, and SOCE activity was found to be increased in SSc fibroblasts. …”
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    A potential new approach for treating systemic sclerosis: Dedifferentiation of SSc fibroblasts and change in the microenvironment by blocking store-operated Ca(2+) entry
  14. 94
    “…However, few drugs can selectively modulate SOCE. 2-Aminoethoxydiphenyl borate (2APB) and its analogs (DPB162 and DPB163) have been reported to inhibit SOCE. …”
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    The 2-aminoethoxydiphenyl borate analog, DPB161 blocks store-operated Ca(2+) entry in acutely dissociated rat submandibular cells
  15. 95
    “…Store-operated calcium (Ca(2+)) entry (SOCE) in skeletal muscle is rapidly activated across the tubular system during direct activation of Ca(2+) release. …”
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    Store-operated Ca(2+) entry is activated by every action potential in skeletal muscle
  16. 96
    “…Furthermore, 2-APB enhanced thapsigargin-evoked SOCE at low concentrations, whereas higher doses caused SOCE inhibition. …”
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    Store-Operated Ca(2+) Entry Is Remodelled and Controls In Vitro Angiogenesis in Endothelial Progenitor Cells Isolated from Tumoral Patients
  17. 97
    “…SOCE, induced by either pharmacological (i.e. cyclopiazonic acid or CPA) or physiological (i.e. …”
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    Enhanced Expression of Stim, Orai, and TRPC Transcripts and Proteins in Endothelial Progenitor Cells Isolated from Patients with Primary Myelofibrosis
  18. 98
    “…In the present study, we examined the functional expression and pharmacological properties of Ca(2+) release-activated Ca(2+) (CRAC) channels that mediate SOCE and evaluated the alkali sensitivity of SOCE in rat odontoblasts. …”
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    High pH-Sensitive Store-Operated Ca(2+) Entry Mediated by Ca(2+) Release-Activated Ca(2+) Channels in Rat Odontoblasts
  19. 99
    “…In neurons, the presence and functions of SOCE are still in question. Here, we show evidences for the existence of SOCE in primary mouse cortical neurons. …”
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    Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical Neurons
  20. 100
    “…Gβ5 also augmented Stim1- and Orai1-dependent SOCE. An ORAI1 loss-of-function mutant did not show inhibition of Gβ5-induced SOCE, and a STIM1-ERM truncation mutant showed no enhancement of SOCE. …”
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    Increased store-operated Ca(2+) entry mediated by GNB5 and STIM1
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