“…However, the heterogeneity of SOCE characteristics in different cell types and the physiological function are still not clear(5-7). …”
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“…However, if and how STIM1 and SOCE function in nerve growth cones during axon guidance remains to be elucidated. …”
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“…SOCE-associated regulatory factor (SARAF) acts as an inhibitor of the SOCE response and, therefore, can be a potential antitumor factor. …”
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“…Finally, the effects of GPN on SOCE and Stim1 was reversed by a dynamin inhibitor, dynasore. …”
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“…The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca(2+)) after their release into the cytoplasm. …”
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“…This work demonstrated the involvement of SOCE in neuropathic pain, implying that SOCE might be a potential target for pain management.…”
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“…The association between dysregulated store-operated calcium entry (SOCE), a key intracellular Ca(2+) signaling pathway and gastroesophageal cancers are emerging. …”
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“…This study shows that SOCE inhibition using BTP2 suppressed the LPS-induced migration and proliferation of breast cancer cells. …”
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“…Store-operated calcium entry (SOCE), a major mechanism that allows calcium entry from the extracellular region through the plasma membrane, is required for several physiological processes. …”
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“…At these junctions, the STIM cytosolic coiled-coil (CC) domains couple to PM Orai1 proteins and gate these Ca(2+) release-activated Ca(2+) (CRAC) channels, which facilitate store-operated Ca(2+) entry (SOCE). Unlike STIM1 and STIM2, which are SOCE activators, the STIM2β splice variant contains an 8-residue insert located within the conserved CCs which inhibits SOCE. …”
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“…Astrocytes may protect microglia by reducing increased SOCE under the conditions of inflammation and a muscarinic receptor blockade.…”
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“…Inositol 1,4,5-trisphosphate receptors (IP(3)Rs, which are encoded by a single gene in flies) are assumed to regulate SOCE solely by mediating ER Ca(2+) release. We show that in Drosophila neurons, mutant IP(3)R attenuates SOCE evoked by depleting Ca(2+) stores with thapsigargin. …”
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“…Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that increase co-localization of proteins required for store-operated Ca(2+) entry (SOCE). Here, we report that SOCE, peak Ca(2+) transient amplitude and muscle force production during repetitive stimulation are increased after exercise in parallel with the time course of TT association with SR-stacks. …”
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“…Store-operated calcium entry (SOCE) by calcium release activated calcium (CRAC) channels constitutes a primary route of calcium entry in most cells. …”
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“…Breast cancer cells remodel the expression and functional role of the molecular components of SOCE. This review focuses on the functional role and remodeling of SOCE in breast cancer cells. …”
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“…Here we show that the invasive fronts of cancer tissues overexpress STIM1, accompanied by active store-operated Ca(2+) entry (SOCE). Interfering SOCE activity by SOCE inhibitors and STIM1 or Orai1 knockdown remarkably affects podosome rosettes formation. …”
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“…PURPOSE OF REVIEW: Store-operated calcium entry (SOCE) is dysregulated in prostate cancer, contributing to increased cellular migration and proliferation and preventing cancer cell apoptosis. …”
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“…The interaction between Ca(2+) sensors STIM1 and STIM2 and Ca(2+) channel-forming protein ORAI1 is a crucial element of store-operated calcium entry (SOCE) in non-excitable cells. However, the molecular mechanism of SOCE in neurons remains unclear. …”
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“…PCB19 also showed a manner equivalent to that of known SOCE inhibitors. PCB19-mediated SOCE inhibition was confirmed by demonstrating the ability of PCB19 to inhibit the SOCE current and thapsigargin-induced Mn(2+) influx. …”
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“…Store-operated calcium entry (SOCE) signaling is involved in cancer progression. …”
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