“…Moreover, resveratrol combined with irradiation treatment lead to alleviated thapsigargin-induced SOCE. In addition, overexpression of STIM1 and Orai1 reversed resveratrol-induced SOCE inhibition and reduced death in A549 cells under irradiation. …”
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“…The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. …”
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“…Store-operated Ca(2+) entry (SOCE) is the stable calcium channel influx in most cells. …”
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“…The mechanism underlying SOCE‐mediated NP remains largely unknown. In this study, we found SOCE‐mediated calcium refilling was significantly higher during neuropathic pain, and the major component Orai1 was specifically co‐localized with neuronal markers. …”
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“…Here we examined the contribution of the store-operated Ca(2+) entry (SOCE) for the pathogenesis of DMD. RT-PCR and Western blot found that the expression level of Orai1, the pore-forming unit of SOCE, was significantly elevated in the dystrophic muscles, while parallel increases in SOCE activity and SR Ca(2+) storage were detected in adult mdx muscles using Fura-2 fluorescence measurements. …”
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“…Store-operated Ca(2+) entry (SOCE) that is elicited by the depletion of the endoplasmic reticulum (ER) Ca(2+) stores constitutes the major Ca(2+) influx pathways in most nonexcitable cells. …”
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“…Degranulation mediated killing mechanism by NK cells is dependent on store-operated Ca(2+) entry (SOCE) and has optimum at moderate intracellular Ca(2+) elevations so that partial block of SOCE optimizes the killing process. …”
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“…In humans, numerous cell stimulation pathways lead to the mobilization of sarco/endoplasmic reticulum (S/ER) stored Ca(2+), resulting in the propagation of Ca(2+) signals through the activation of processes, such as store-operated Ca(2+) entry (SOCE). SOCE provides a sustained Ca(2+) entry into the cytosol; moreover, the uptake of SOCE-mediated Ca(2+) by mitochondria can shape cytosolic Ca(2+) signals, function as a feedback signal for the SOCE molecular machinery, and drive numerous mitochondrial processes, including adenosine triphosphate (ATP) production and distinct cell death pathways. …”
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“…In tumour cells chorein up-regulates ORAI1, a Ca(2+)-channel accomplishing store operated Ca(2+)-entry (SOCE) upon stimulation by STIM1. Furthermore SOCE could be up-regulated by lithium. …”
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“…Recent research has shown that it is also complemented by stromal interaction molecule (STIM) protein-mediated store-operated Ca(2+) entry (SOCE). SOCE is described as Ca(2+) flow into cells in response to the depletion of endoplasmic reticulum Ca(2+) stores. …”
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“…Store-operated Ca(2+) entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels is critical for lymphocyte function and immune responses. …”
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“…Here, we investigate the role of store-operated Ca(2+) entry (SOCE) mediated by the Ca(2+) channel ORAI1 and its activators STIM1 and STIM2 in T-ALL. …”
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“…The Ca(2+) selective channel ORAI1 and endoplasmic reticulum (ER)-resident STIM proteins form the core of the channel complex mediating store operated Ca(2+) entry (SOCE). Using liquid phase electron microscopy (LPEM), the distribution of ORAI1 proteins was examined at rest and after SOCE-activation at nanoscale resolution. …”
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“…The dimeric ER Ca(2+) sensor STIM1 controls store-operated Ca(2+) entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane. …”
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“…Store-operated Ca(2+) entry (SOCE) is a major mechanism controlling Ca(2+) signaling and Ca(2+)-dependent functions and has been implicated in immunity, cancer, and organ development. …”
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“…Recruitment of STIM proteins to cortical endoplasmic reticulum (cER) domains forming membrane contact sites (MCSs) mediate the store-operated Ca(2+) entry (SOCE) pathway essential for human immunity. The cER is dynamically regulated by STIM and tethering proteins during SOCE, but the ultrastructural rearrangement and functional consequences of cER remodeling are unknown. …”
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“…Store-operated calcium entry (SOCE) inhibitors and cells in which a key component of SOCE (STIM1) was knocked out were used as glutamate-induced oxidative stress injury models. …”
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“…NAGly was recently shown to depress store-operated Ca(2+) entry (SOCE) but its mechanism of action remains elusive. …”
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“…Store-operated Ca(2+) entry (SOCE) represents a predominant Ca(2+) influx pathway in non-excitable cells. …”
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“…Verbal learning test index items of the CNT improved markedly in the SOCE group compared to the placebo group (p < 0.05). …”
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