“…On the contrary, substitution with carboxyl-terminal residues of two or three aromatic residues belonging to extended hydrophobic patches on the protein surface provided soluble but still active forms of the protein. These mutants could be expressed in isotopically enriched forms for NMR studies and the maximal attainable concentration was sufficient for the acquisition of (1)H-(15)N HSQC spectra that represent the starting point for future drug development projects targeting Alzheimer’s disease.…”
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“…When imaged, the detergent-soluble vimentin appears to consist of small fragments the length of one or several unit-length filaments. …”
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“…FZ250 showed greater solubility than FS; the difference was only significant in artificial saliva. …”
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“…These weaknesses could be avoided if a means were found to prepare individual macromolecules with crosslinked binding sites with soluble linear polymeric arms. This process has been made possible by controlled free radical polymerization techniques that can form pseudo-living polymers. …”
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“…Here we determine the reductase binding site on the hydroxylase of a BMM enzyme, soluble methane monooxygenase (sMMO) from Methylococcus capsulatus (Bath). …”
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“…Soluble factors in blood plasma have a substantial impact on both the innate and adaptive immune responses. …”
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“…The level of plasma soluble ICAM-1 (sICAM-1) has been associated with the pathogenesis of several diseases. …”
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“…Several members of the staphylococcal phenol-soluble modulin (PSM) peptide family exhibit pronounced capacities to lyse eukaryotic cells, such as neutrophils, monocytes, and erythrocytes. …”
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“…In cyanobacteria, the photoactive soluble Orange Carotenoid Protein (OCP) is involved in photoprotective mechanisms as a highly active singlet oxygen and excitation energy quencher. …”
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“…We found that the target protein was partially soluble although major portions of the protein remained in the inclusion bodies. …”
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“…This raises the question whether the solubility of natural protein sequences can be improved. …”
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“…We compared plasma soluble Sdc1 concentrations, in relation to placental Sdc1 expression, in uncomplicated (control) and preeclamptic pregnancies. …”
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“…Soluble suppression of tumorigenicity 2 (sST2) has emerged as a biomarker of cardiac stretch or remodeling, and has demonstrated a role in acutely decompensated heart failure. …”
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“…Often solubility of a drug determines its pharmaceutical and therapeutic performance. …”
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“…Recent findings have suggested that phenol-soluble modulins (PSMs), amphipathic peptide toxins with broad cytolytic activity, are widespread in staphylococci, but there has been no systematic assessment of PSM production in CoNS other than S. epidermidis. …”
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“…Solubility and sorption tests were performed according to ISO4049. …”
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“…Instructive snapshots at the interface of homogeneous and heterogeneous iron catalysis were recorded by the isolation of novel Fe nanocluster architectures that act as catalyst reservoirs and soluble seeds of particle growth.…”
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