“…We also compare the gold standard solubilities from the 2019 Solubility Challenge with a set of literature-based solubilities for most of the same compounds.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The analysis of the selected molecular descriptors in these models was also found to be informative and suggested that several charge-based descriptors and isotype may play important roles in mAb solubility. The combination of high throughput relative solubility experimental techniques in concert with efficient machine learning QSAR models offers an opportunity to rapidly screen potential mAb candidates and to design therapeutics with improved solubility characteristics.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this paper, we have synthesized two water-soluble pillar[5]arenes with peripheral rims bearing opposite charges and investigated their influence on Kemp elimination reaction of 1,2-phenylisoxazole derivatives. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We present the synthesis of new chiral water-soluble dimeric capsules by the multicomponent Mannich reaction between charged amino acids (glutamic acid or arginine), resorcinarene, and formaldehyde and by subsequent self-assembly. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Eight fluorine-functionalized ionic liquids were synthesized and the oxygen solubility was compared to commercial ionic liquids without the extra fluorinated chain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] Determining the aqueous solubility of molecules is a vital step in many pharmaceutical, environmental, and energy storage applications. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND & AIMS: Soluble α-Klotho (s-Klotho) is a circulating protein with pleiotropic effects that mainly induce protective effects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso

“…Therefore, in this review, the possible techniques for the dissolution/solubility and permeability improvements have been addressed which could enhance the dissolution and permeability up to several times. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The present study aimed to develop novel suspended self-nanoemulsifying drug delivery system (Su-SNEDDS) to enhance the solubility and dissolution rate. The Su-SNEDDS was prepared by saturation and suspension of ALH in SNEDDS with ultrasonication energy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Then, two successive stages of membrane filtration were carried out: the first one to essentially remove/retain the particles (cellular debris) by microfiltration and the second one to concentrate (ultrafiltration) the soluble compounds of the permeate from the previous step. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] Water solubility and structural stability are key merits for proteins defined by the primary sequence and 3D-conformation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Significantly, control experiments demonstrate that the guest binding performance of CWP[5]L is superior to its counterpart water-soluble macrocyclic receptor in traditional pillararenes.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Despite unambiguous results of in vitro studies and high selectivity index, the poor water solubility of these compounds prevented in vivo evaluation of their antiviral properties. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, the clinical use of NCTD is limited due to its poor solubility, low bioavailability, and toxic effects on normal cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, increasing water solubility is a critical step toward solving this problem. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pyridinium, imidazolium, and phosphonium derivatives also exhibited solubility-switchable properties; acetal-type ionic liquids were soluble in organic solvents, while diol-type ones exhibited a preference for being dissolved in the aqueous phase. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso