“…Interestingly, fluorescence spectroscopy revealed that the pH within the pellet cores substantially differed upon exposure to acetate buffer pH = 3.5 and phosphate buffer pH = 7.4, resulting in significant differences in drug solubility (verapamil being a weak base) and faster drug release at lower pH: from ensembles of pellets and single pellets. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, it has some limitations, including a short half-life and poor solubility in aqueous solutions. This study aimed to enhance the efficacy of near-infrared (NIR) fluorescence imaging by overcoming the shortcomings of ICG using a nano-drug delivery system and improve target specificity in cervical cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND AND PURPOSE: Ursolic acid (UA) exhibits anti-hepatocarcinoma and hepatoprotective activities, thus promising as an effective oral cancer therapy. However, its poor solubility and permeability lead to low oral bioavailability. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The compounds crystallize in a filled version of the orthorhombic Zr(2)Ni(1–x)P-type structure with x = 0.52; their stoichiometry, determined from both single-crystal and powder X-ray diffraction data, is centered on Ho(2)Ni(0.8)T(1.2) with a narrow solid solubility range for the silicide, while the germanide appears to be a line phase. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition to the common features of carbon dots (CDs), such as high light stability, small size, low toxicity, good aqueous solubility, and favorable biocompatibility, these N,Cl-CDs exhibited excellent recognition and selectivity for Gram-positive bacteria by doping with N and Cl elements using DES. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Therefore, we chose CDC20 as the potential therapeutic target. 7,416 natural ligands were conducted to bind firmly with CDC20, and among these ligands, ZINC000004098930 was regarded as the potential ideal ligand, owing to its non-hepatotoxicity, more solubility level and less carcinogenicity than the reference drug, apcin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The paramagnetic lanthanide complexes with polyaminopolycarboxylate (PAPC) ligands attract considerable attention from the standpoint of potential applications thereof as relaxation agents used in medical magnetic resonance imaging (MRI) and in luminescent materials, as well as owing to promising use thereof as paramagnetic labels for studying the properties of biopolymers since they exhibit thermodynamic stability, good solubility in aqueous media and moderate toxicity. For the last decades, the NMR methods have been used to determine the physical and chemical properties of paramagnetic Ln compounds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A good adhesion and homogeneity of the multilayer system was obtained by SEM, and they also demonstrated low oxygen permeability (40.87 ± 5.20 cm(3) mm m(−2) day) and solubility (39.19 ± 0.16%) values, while mechanical properties were comparable with commercial plastic films. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On the basis of the structure–activity relationships that we have explored, this study aims to incorporate carbamoyl groups to the alcoholic hydroxyl groups of silibinin to improve its capability in selectively suppressing AR-positive prostate cancer cell proliferation together with water solubility. To this end, a feasible approach was developed to regioselectively introduce a carbamoyl group to the secondary alcoholic hydroxyl group at C-3 without causing the undesired oxidation at C2–C3, providing an avenue for achieving 3-O-carbamoyl-5,7,20-O-trimethylsilybins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Since nucleic acid and peptide systems vary in structure, connectivity, functional group availability and placement, as well as stability and solubility, tailored synthetic approaches are needed for conjugating to each of these biomacromolecule types. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Foslevodopa/foscarbidopa, formerly known as ABBV-951, is a formulation of levodopa/carbidopa prodrugs with solubility that allows for subcutaneous (SC) infusion and is in development for the treatment of motor complications for patients with advanced Parkinson’s disease (aPD). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, poor water solubility, extensive phase II metabolism and apical efflux have posed limitations to the bioavailability of hesperidin and hesperetin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As a result, enhanced overall protein stability, expression, immunostimulatory capabilities, and solubility of the designed construct were observed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONTEXT: Oridonin (ORI) has obvious anticancer effects, but its solubility is poor. Nanocrystal (NC) is a novel nano-drug delivery system for increasing bioavailability for ORI. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The hardness of PBM-2 implied the potential application in bone regeneration, while it resulted in the reduction of solubility when compared with PBM-1, which made it difficult to be dissolved and hydrogenated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An enhancement of the fluorescence quantum yield (φ(F)) could be observed due to the better water solubility of Cy5. [(68)Ga]Ga-NODAGA-K(Cy5)DKPPR was radiosynthesized efficiently, presented hydrophilic properties (log D = −1.86), and had high in vitro stability (>120 min). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the identified two QSMs were found to be good in solubility, absorption, and permeation and less toxic in nature, as revealed by pharmacokinetics and toxicity analyses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the absence and presence of the SFM, the transformations of the tristimulus color coordinates, size, agglomeration state, surface charge and solubility of the e-TiO(2)-NPs in the salivary, gastric and intestinal digestion fluids were compared with those before digestion. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The prepared co-precipitate complex was used for the development of the sustained-release formulation to overcome the high metabolic and poor solubility problems associated with ABX. Furthermore, the co-precipitate complex was formulated as a suspension in an aqueous floating gel-forming vehicle of sodium alginate with chitosan, which might be beneficial for targeting the stomach as a good absorption site for ABX. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All the microcapsules had high water solubility (86.35% for GA to 98.74% for MD and 90.51% for MDGA). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso