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  1. 55901
    “…Partition coefficient and water solubility determination showed that both lipophilicity and hydrophilicity of the compound are more than cisplatin. …”
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    Probing the biomolecular (DNA/BSA) interaction by new Pd(II) complex via in-depth experimental and computational perspectives: synthesis, characterization, cytotoxicity, and DFT approach
  2. 55902
    “…[Image: see text] Exploration of alternate solid forms for dasatinib, a potent oncogene tyrosine kinase inhibitor classified under Biopharmaceutics Classification System (BCS) class II drugs with low water solubility and high permeability, has been performed using COSMO-RS excess enthalpy (Hex) to increase dissolution. …”
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    Stable Fatty Acid Solvates of Dasatinib, a Tyrosine Kinase Inhibitor: Prediction, Process, and Physicochemical Properties
  3. 55903
    “…OBJECTIVE: To evaluate the physicochemical (sorption (SOR), solubility (SOL), and degree of conversion (DC)) and mechanical (flexural strength (FS), modulus of elasticity (ME), and compressive strength (CS)) properties of adhesives with different water contents (D(2)O). …”
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    How Water Content Can Influence the Chemomechanical Properties and Physical Degradation under Aging of Experimental Adhesives
  4. 55904
    “…Furosemide is a diuretic drug widely used in chronic renal failure. The drug has low solubility and permeability, which cause clinical problems. …”
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    In vitro release studies of furosemide reference tablets: influence of agitation rate, USP apparatus, and dissolution media
  5. 55905
    “…(MITC) exhibit excellent effects against skin photoaging, its application is restricted because of its characteristics, such as extremely low water solubility, bioavailability, and easy degradation. Currently, flexible nanoliposomes have gained increasing interest as a biocompatible polymer for applications such as transdermal drug delivery. …”
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    Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
  6. 55906
    “…However, its poor aqueous solubility and low systemic bioavailability have been the challenges in improving the therapeutic efficacy of curcumin. …”
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    Formulation Design and Cell Cytotoxicity of Curcumin-Loaded Liposomal Solid Gels for Anti-Hepatitis C Virus
  7. 55907
    “…The experimental results suggested that high solubility was the premise condition for the fly ashes exhibiting an inhibitory effect on NO removal. …”
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    Reaction Behavior and Influencing Mechanisms of Different Fly Ashes on the NO Removal by Using the Ultraviolet Irradiating Chlorite Method
  8. 55908
    “…Nevertheless, Si306 antitumor activity is associated with sub-optimal aqueous solubility, which might hinder its further development. …”
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    The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma
  9. 55909
    “…Block copolymers (BCPs), specifically, [NBM-mIM][Tf(2)N] and [NBM-ImC(n)mIm] [Tf(2)N](2) (n = 4 and 6) were synthesized at two different compositions, which generated high molecular weight polymers with decent solubility relative to homo- and random (co)polymers of [NBM-DILs] [Tf(2)N](2). …”
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    Poly(ionic liquid)s with Dicationic Pendants as Gas Separation Membranes
  10. 55910
    “…An increase in water solubility and the resultant hydrodynamic size of VTX via PEGylation improved the pharmacokinetics of VTX by avoiding protein interactions and lessening the extravasation from blood. …”
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    A novel polyethylene glycol (PEG)‐drug conjugate of Venetoclax, a Bcl‐2 inhibitor, for treatment of acute myeloid leukemia (AML)
  11. 55911
    “…The pharmaceutical uses of quercetin are limited due to many problems associated with low solubility, bioavailability, permeability, and instability. …”
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    Synergistic Effect of Quercetin Magnetite Nanoparticles and Targeted Radiotherapy in Treatment of Breast Cancer
  12. 55912
    “…However, poor water solubility, low bioavailability, short half-life, and weak tumor accumulation hinder in vivo applications and antitumor effects of Que. …”
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    Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment
  13. 55913
    “…However, its anti-cancer efficiency is largely impaired by some of its concomitant negative properties, including its poor solubility, low cellular uptake, and severe reported side effects. …”
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    Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity
  14. 55914
    “…The stabilization of supramolecular architectures in crystals for compounds 1–5 occurs due to π–π-bonding between heterocycles and hydrogen interactions that provide good solubility in aqueous solutions. The stability of the complexes upon dissolution in 5% dextrose and 0.9% NaCl was confirmed by UV-vis spectroscopic and NMR ((1)H) data. …”
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    What are the prospects for using complexes of copper(ii) and zinc(ii) to suppress the vital activity of Mycolicibacterium smegmatis?
  15. 55915
    “…The IC(50) values for free Cinn and CB[7]–Cinn inclusion complexes were 240.17 ± 32.46 μM and 260.47 ± 20.83 μM against U-87 cells and 85.93 ± 3.35 μM and 176.3 ± 7.79 μM against MDA-MB-231 cells, respectively, despite the enhanced aqueous solubility. No significant cytotoxicity was noticed for the free CB[7].…”
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    Cinnamaldehyde–cucurbituril complex: investigation of loading efficiency and its role in enhancing cinnamaldehyde in vitro anti-tumor activity
  16. 55916
    por Asen, Nancy D., Aluko, Rotimi E.
    Publicado 2022
    “…In comparison to PPC, the >50 kDa fractions showed improved solubility (>60%), oil holding capacity (~100%), protein content (~7%), foam capacity (>10%), foam stability (>7%), water holding capacity (>16%) and surface hydrophobicity (~50%). …”
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    Physicochemical and Functional Properties of Membrane-Fractionated Heat-Induced Pea Protein Aggregates
  17. 55917
    “…When the concentration of ceftriaxone in the gallbladder exceeds the solubility of its calcium salt, precipitation occurs, forming a biliary sludge. …”
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    Rapid Onset of Ceftriaxone-Induced Cholelithiasis in an Adult Patient
  18. 55918
    “…However, DATS is not suitable for clinical use due to its low solubility. The current study seeks to improve DATS bioavailability and assess its chemopreventive and chemosensitizing properties in an AOM-induced colorectal cancer model. …”
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    Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis
  19. 55919
    “…This strategy overcomes propolis processing problems due to limitations to its solubility. The integration of different combinations of extracts allows more than 73 wt% of propolis to be incorporated into the fibers. …”
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    Propolis Integration Methods into Solutions for Highly Loaded Propolis Fibers by Needleless Electrospinning
  20. 55920
    “…The water barrier properties of the films improved significantly as the hydrophobicity of the PSG–CuZn film increased by 32.9% while the water absorptivity and solubility decreased by 51.49% and 60% compared to the PSG film. …”
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    Metallic Nanoparticle Integrated Ternary Polymer Blend of PVA/Starch/Glycerol: A Promising Antimicrobial Food Packaging Material
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