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  1. 56121
    “…RESULTS: Results displayed that fluorescence (Quantum yield = 5.63%) and nontoxic PCC-based CDs (PCC-CDs) with abundant chemical groups exhibited solubility and tiny sizes at average of (1.93 ± 0.53) nm, which may be beneficial for its inherent biological activity. …”
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    Green Phellodendri Chinensis Cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice
  2. 56122
    “…But once extravasated into acidic tumor interstices, the increased solubility of PEG led to breakage of the supramolecular nanostructure and dissolution of MPNs to small-sized (< 20 nm) nanoparticles, promoting deep penetration and distribution in tumor tissues. …”
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    Facile fabrication of multi-pocket nanoparticles with stepwise size transition for promoting deep penetration and tumor targeting
  3. 56123
    “…The simulation results show that, when the values of K(+), Na(+), Mg(2+), Ca(2+), Cl(−) and SO(4)(2−) in the solvent are 0.1%, 2.9%, 3.77%, 0.05%, 15.72% and 0.13% respectively, the solubility of low-grade solid potash ores is stronger, which is more conducive to selective ore dissolution. …”
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    Simulation study on the mining conditions of dissolution of low grade solid potash ore in Qarhan Salt Lake
  4. 56124
    “…BACKGROUND: BF211, a derivative of bufalin (BF), shows significantly improved solubility and potent antitumor efficiency compared to BF. …”
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    Surfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity
  5. 56125
    “…The higher deformation, lattice and surface energies of form II are consistent with its lower solubility and hence bioavailability. CONCLUSION: Inter-relationship between molecular, solid-state and surface structures of the polymorphic forms of ritonavir are quantified in relation to their physical-chemical properties. …”
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    Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties
  6. 56126
    “…Unfortunately, the underlying optimization problem is under-determined, and so mutations introduced to improve the specified property may come at the expense of unmeasured, but nevertheless important properties (ex. solubility, thermostability, etc). We address this issue by formulating DE as a regularized Bayesian optimization problem where the regularization term reflects evolutionary or structure-based constraints. …”
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    Bayesian optimization with evolutionary and structure-based regularization for directed protein evolution
  7. 56127
    “…Because of its wide application in agricultural production and high solubility in water, it poses potential risks to aquatic environments and food chain. …”
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    Biodegradation of flonicamid by Ensifer adhaerens CGMCC 6315 and enzymatic characterization of the nitrile hydratases involved
  8. 56128
    “…The compound has good solubility (128 μg/ml) and permeability (86 nM/s). GSK137 caused little change in cell viability or proliferation in four BCL6-expressing B-cell lymphoma lines, although there was modest dose-dependent accumulation of G1 phase cells. …”
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    GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice
  9. 56129
    “…The developed program calculated the total charging amount C(0) and diffusivity D, which were then used to calculate the H(2) solubility S and permeability P for variation of pressure. …”
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    Determination of permeation properties of hydrogen gas in sealing rubbers using thermal desorption analysis gas chromatography
  10. 56130
    “…Nanobodies have some outstanding features, such as high stability, solubility and affinity for diagnostic and therapeutic applications. …”
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    Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1
  11. 56131
    “…Four different constructs were tested for the level of expression and solubility, and the construct with a linker, 6xHisSUMO3xGly-cecropin B, showed the highest expression. …”
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    Expression of Antimicrobial Peptide (AMP), Cecropin B, in a Fused Form to SUMO Tag With or Without Three-Glycine Linker in Escherichia coli and Evaluation of Bacteriolytic Activity of the Purified AMP
  12. 56132
    “…Parameters (Vickers microhardness, compressive strength, elastic modulus, water sorption and solubility) were determined in their initial state (control group, n = 3 for microhardness, n = 5 for the other parameters) and after 14, 30, 90 and 180 days (n = 3 for microhardness, n = 5 for the other parameters for each composite group, time point and media). …”
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    Influence of artificial aging: mechanical and physicochemical properties of dental composites under static and dynamic compression
  13. 56133
    “…This can be considered one of the main reasons for increasing solubility and absorption of DESs. Most active pharmaceutical ingredients (APIs) have polar functional groups containing amide, carboxylic acid, alcohol or quaternary ammonium groups. …”
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    Controlled release of pharmaceutical agents using eutectic modified gelatin
  14. 56134
    “…Spray freeze drying (SFD) and spray drying (SD) techniques were employed to prepare tamibarotene powder formulations, and cyclodextrin was used as the sole excipient to enhance drug solubility. With the employment of appropriate atomizing nozzles, particles of size above 10 μm and below 5 μm could be produced for nasal and lung deposition, respectively. …”
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    Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration
  15. 56135
    “…We arrive at compounds with improved and favorable solubility and stability characteristics that are tested for inhibiting viral replication. …”
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    Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
  16. 56136
    “…RESULTS: The self-assembly nanocomplex (CAT-Ce6) generated sufficient O(2) and promoted the solubility of Ce6 simultaneously, which enhanced PDT significantly. …”
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    Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy
  17. 56137
    “…For this probe, we introduced biotin on the naphthalimide fluorophore, which increased the water solubility and enabled the probe to aggregate in cancer cells by targeting specific receptor overexpressed on the surface of cancer cell membrane. …”
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    A new-type HOCl-activatable fluorescent probe and its applications in water environment and biosystems
  18. 56138
    “…This study established that NifH from Dehalococcoides ethenogenes did not require NifM for solubility, [Fe-S] cluster occupancy or functionality, and that NifH from Geobacter sulfurreducens was more resistant to O(2) exposure than the other NifH proteins tested. …”
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    A colorimetric method to measure in vitro nitrogenase functionality for engineering nitrogen fixation
  19. 56139
    “…The new materials were fully characterized from the physicochemical point of view (solubility, 1D and 2D NMR, FT-IR, UV–Vis, GPC, DSC) and showed interesting hybrid properties compared to precursors. …”
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    Inulin-g-poly-D,L-lactide, a sustainable amphiphilic copolymer for nano-therapeutics
  20. 56140
    “…Despite its potential, NCS is a Biopharmaceutical Classification System (BCS) Class II drug and is consequently characterized by low aqueous solubility, poor dissolution rate and reduced bioavailability, which limits its applicability. …”
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    Direct cyclodextrin-based powder extrusion 3D printing for one-step production of the BCS class II model drug niclosamide
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