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  1. 56241
    “…The ITPA adhesiveness of the eba was significant and negatively correlated with the solubility index (p < .05, r = −0.89) and the ash content (p < .05, r = −0.87) of the BFG. …”
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    Relationship between quality attributes of backslopped fermented gari and the sensory and instrumental texture profile of the cooked dough (eba)
  2. 56242
    “…Astragaloside (AS) has an anti-osteoporotic effect, but its poor water solubility and low bioavailability limit its application. …”
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    Alendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats
  3. 56243
    “…In 4% of the strains, IAA production exceeded 53 mg L(−1), while a high level of phosphorus solubility was verified in 6% of the strains. No strain was found to have the capability of producing HCN. …”
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    Characterization of plant growth-promoting rhizobacteria (PGPR) in Persian walnut associated with drought stress tolerance
  4. 56244
    “…However, due to its low solubility and poor bioavailability, widespread therapeutic applications of baicalin still remain a challenge. …”
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    Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review
  5. 56245
    “…PURPOSE: We designed a novel isoliquiritigenin (ISL) loaded micelle prepared with DSPE-PEG(2000) as the drug carrier modified with the brain-targeting polypeptide angiopep-2 to improve the poor water solubility and low bioavailability of ISL for the treatment of acute ischemic stroke. …”
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    Long-Circulation and Brain Targeted Isoliquiritigenin Micelle Nanoparticles: Formation, Characterization, Tissue Distribution, Pharmacokinetics and Effects for  Ischemic Stroke
  6. 56246
    “…However, the clinical potential of TP is plagued by its poor aqueous solubility, short half-life, and biotoxicity. Therefore, developing an ideal vehicle to efficiently load TP and achieving targeted delivery to melanoma is a prospective approach for making full use of its antitumor efficacy. …”
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    αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma
  7. 56247
    “…Furthermore, although ascorbic acid is often administered to maximize calcium solubility and to enhance intestinal calcium absorption, it apparently had no effect on calcium transport across the FeCl(3)- and 1,25(OH)(2)D(3)-treated Caco-2 monolayer. …”
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    Fe(3+) opposes the 1,25(OH)(2)D(3)-induced calcium transport across intestinal epithelium-like Caco-2 monolayer in the presence or absence of ascorbic acid
  8. 56248
    “…Besides, all the ligands are non-carcinogenic, excluding L04, and have good water solubility and no AMES toxicity. The discovery of preclinical drug candidate molecules and the structural elucidation of pharmacological therapeutic targets have expedited both structure-based and ligand-based drug design. …”
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    In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective
  9. 56249
    “…Protein-sol and the SOLPro servers showed the solubility of the vaccine. Moreover, the high mobile regions in the vaccine’s structure were reduced and the vaccine’s stability was improved by disulfide engineering. …”
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    A novel strategy for developing vaccine candidate against Jaagsiekte sheep retrovirus from the envelope and gag proteins: an in-silico approach
  10. 56250
    “…Developed models include Multivariate Linear Regression (MLR), Artificial Neural Network (ANN), Adaptive Neuro-Fuzzy Inference System (ANFIS), Group Method of Data Handling (GMDH), and four hybrid forms of GMDH and Support Vector Regression (SVR) in combination with Henry Gas Solubility Optimization (HGSO) and Equilibrium Optimizer (EO) algorithms. …”
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    Application of classical and novel integrated machine learning models to predict sediment discharge during free-flow flushing
  11. 56251
    “…Baicalein (BA) has been confirmed as an inhibitor of bacterial biofilm with less pronounced effects owing to its poor solubility and absorption. Studies have found that β-cyclodextrin-grafted chitosan (CD-CS) can improve drug efficiency as a drug carrier. …”
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    Preparation, Characterization, and Staphylococcus aureus Biofilm Elimination Effect of Baicalein-Loaded β-Cyclodextrin-Grafted Chitosan Nanoparticles
  12. 56252
    “…Succinylation increased the solubility of the excipients, allowing their use at relevant concentrations for protein stabilization. …”
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    Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody
  13. 56253
    “…Effective processes for synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio to achieve sufficient potency while avoiding aggregation or solubility problems, and 3) a homogeneous product to facilitate approval by regulatory agencies. …”
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    A glyco-engineering approach for site-specific conjugation to Fab glycans
  14. 56254
    “…Pneumococcal isolates were identified by optochin sensitivity and bile-solubility tests. Serotyping was done using Quellung Method. …”
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    Nasopharyngeal Carriage of Streptococcus pneumoniae Serotypes Among Healthy Children in Northern India
  15. 56255
    “…Ripretinib and its active metabolite (DP‐5439) are cleared mainly via cytochrome P450 enzyme 3A4/5 (CYP3A4/5), and ripretinib solubility is pH‐dependent, thus the drug–drug interaction potentials of ripretinib with itraconazole (strong CYP3A inhibitor), rifampin (strong CYP3A inducer), and pantoprazole (proton pump inhibitor) were each evaluated in open‐label, fixed‐sequence study designs. …”
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    Effects of CYP3A Inhibition, CYP3A Induction, and Gastric Acid Reduction on the Pharmacokinetics of Ripretinib, a Switch Control KIT Tyrosine Kinase Inhibitor
  16. 56256
    “…Thence, the main objective of this work was to use the chloroform extract (ChlE) of D. simplex to prepare its nanosuspension (ChlE-NS) formulation to increase its aqueous solubility, thereby improving its bioactivity. By using FTIR, GC/MS analysis, and phytochemical screening assays, the chemical profiling of ChlE was assessed. …”
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    Enhancement of cytotoxic and antioxidant activities of Digenea simplex chloroform extract using the nanosuspension technique
  17. 56257
    “…Andrographolide (AG), a major active constituent of Andrographis paniculata, is known to hinder proliferation of several types of cancer cells. However, its poor solubility and cellular permeability restrict its use in clinical applications. …”
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    Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells
  18. 56258
    “…However, the extremely low solubility and poor body absorptive capacity limit its application in clinical medicine. …”
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    Multifunctional Nano-Realgar Hydrogel for Enhanced Glioblastoma Synergistic Chemotherapy and Radiotherapy: A New Paradigm of an Old Drug
  19. 56259
    “…N-(3,4,5-trichlorophenyl)-2 (3-nitrobenzenesulfonamido) benzamide, abbreviated as IMB16-4, which may be effective for the treatment of cholestasis. However, its poor solubility and bioavailability seriously obstruct the research programs. …”
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    New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats
  20. 56260
    “…The much slower brush growth achieved in the latter case is attributed to the relatively low aqueous solubility of the AGEO5MA monomer. X-ray photoelectron spectroscopy (XPS) analysis confirmed that precursor PGEO5MA brushes were essentially fully oxidized to the corresponding PAGEO5MA brushes within 30 min of exposure to a dilute aqueous solution of sodium periodate at 22 °C. …”
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    Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications
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