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  1. 56321
    “…CONCLUSION: The present study shows that the type and structure of organic/bioorganic shells of quantum dots determine their biocompatibility and are crucial for their application in imaging in vivo, due to the effects of the shell on the following properties: colloidal stability, solubility in physiological fluids, influence of the basic physiological parameters, and cytotoxicity.…”
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    Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics
  2. 56322
    “…The three conjugates showed ten-fold higher solubility in the liquid oil phase Miglyol 808 than DX. …”
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    Development and optimization of oil-filled lipid nanoparticles containing docetaxel conjugates designed to control the drug release rate in vitro and in vivo
  3. 56323
    “…BACKGROUND: Nowadays, many cytotoxic anticancer drugs exhibit low solubility and poor tumor selectivity, which means that the drug formulation is very important. …”
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    Supramolecular micellar nanoaggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery
  4. 56324
    “…However, the poor water solubility of celastrol restricts its further application. …”
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    Celastrol nanoparticles inhibit corneal neovascularization induced by suturing in rats
  5. 56325
    “…Additionally, the poor water solubility of celastrol restricts further therapeutic applications. …”
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    Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model
  6. 56326
    “…Nevertheless, while TCN 201 is a potent antagonist it must be borne in mind that its ability to block GluN2A-containing NMDARs is dependent on the GluN1-agonist concentration and is limited by its low solubility.…”
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    TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner
  7. 56327
    “…The effectiveness of antibiotic detection is influenced by the solubility of the assayed compounds, indicator strain sensitivity, culture media and assay configuration. …”
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    Prescreening bacterial colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system
  8. 56328
    “…None of the drugs were highly lipophilic, showing high water solubility (> 45 mM) and low distribution into octanol (log D(7.4) < 2). …”
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    Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity
  9. 56329
    “…RESULTS: TAA/DA-Chit nanoparticles were prepared with a TAA-loading capacity in the range of 12%–82%, which increased the water solubility of TAA from 0.3 mg/mL to 2.1 mg/mL. These nanoparticles showed oblate shapes 100–550 nm in size in transmission electron microscopic images and had positive zeta potentials. …”
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    Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells
  10. 56330
    “…However, the delivery of Q10 to deeper layers of skin is challenging due to low aqueous solubility of Q10. Liposomes and solid lipid nanoparticles (SLN) have many advantages to accomplish the requirements in topical drug delivery. …”
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    A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers
  11. 56331
    “…BACKGROUND: Considering the observations that linoleic acid conjugated with paclitaxel (CLA-PTX) possesses antitumor activity against brain tumors, is able to cross the blood–brain barrier, but has poor water solubility, the purpose of this study was to prepare a novel CLA-PTX microemulsion and evaluate its activity against brain tumors in vitro and in vivo. …”
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    Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings
  12. 56332
    “…Furthermore, in order to increase the solubility and efficacy of these heterocycles, the interest is now shifted to the salts of these compounds. …”
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    Design, synthesis and structural studies of meta-xylyl linked bis-benzimidazolium salts: potential anticancer agents against ‘human colon cancer’
  13. 56333
    “…CONCLUSIONS: Aqueous solubility of solvate-VIII was found to be maximum, however, solvate-I and VIII showed better reduction in total cholesterol and triglyceride levels as compared to atorvastatin against triton-induced dyslipidemia.…”
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    Characterisation and evaluation of pharmaceutical solvates of Atorvastatin calcium by thermoanalytical and spectroscopic studies
  14. 56334
    “…However, compounds currently known to specifically inhibit DNA-PK are limited by poor pharmacokinetics: these compounds have poor solubility and have high metabolic lability in vivo leading to short serum half-lives. …”
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    Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond
  15. 56335
    “…HHPY exhibits similar reactivity toward CO(2) to PZ, but with improved aqueous solubility. The α-methyl-substituted MHHPY favours HCO(3)(−) formation, but MHHPY exhibits comparable CO(2) absorption capacity to conventional amines MEA and DEA. …”
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    An ATR-FTIR Study on the Effect of Molecular Structural Variations on the CO(2) Absorption Characteristics of Heterocyclic Amines, Part II
  16. 56336
    “…Incorporating CLC could not affect the film microstructure. The solubility of the gelatin based film incorporated with CLC was not affected, especially at a high level of addition (p>0.05). …”
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    Mechanical, physico-chemical, and antimicrobial properties of gelatin-based film incorporated with catechin-lysozyme
  17. 56337
    “…METHODS: The different families of storage proteins were extracted following differential solubility, and their contents were estimated using the Bradford method. …”
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    Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa
  18. 56338
    “…The consumption of HC by human might prevent cardiovascular disease and some types of cancer. The solubility of HCs is increased through thioester conjugation to various compounds such as quinic acid, shikimic acid, malic acid, anthranilic acid, and glycerol. …”
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    Production of hydroxycinnamoyl-shikimates and chlorogenic acid in Escherichia coli: production of hydroxycinnamic acid conjugates
  19. 56339
    “…The lyophilized hydrolysate presented almost 100% solubility at pH 3-pH 9, and maintained nearly 100% activity at pH 5-pH 8 at 0°C- 4°C and room temperature during the first 6 months of storage. …”
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    Housefly larvae hydrolysate: orthogonal optimization of hydrolysis, antioxidant activity, amino acid composition and functional properties
  20. 56340
    “…Nanobubbles (<200 nm in diameter) have several unique properties such as long lifetime in liquid owing to its negatively charged surface, and its high gas solubility into the liquid owing to its high internal pressure. …”
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    Oxygen and Air Nanobubble Water Solution Promote the Growth of Plants, Fishes, and Mice
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