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  1. 56381
    “…The effect of the number of HEE groups of the HEE-PRXs, which was modified to impart water solubility to the PRXs, on cellular internalization efficiency, lysosomal localization efficiency, and cholesterol reduction ability in NPC disease-derived fibroblasts (NPC1 fibroblasts) was also investigated. …”
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    Lysosomal pH-inducible supramolecular dissociation of polyrotaxanes possessing acid-labile N-triphenylmethyl end groups and their therapeutic potential for Niemann-Pick type C disease
  2. 56382
    “…Small interfering RNA (siRNA) delivery is a prospective method in gene therapy, but it has application limitations such as negative charge, water solubility and high molecular weight. In this study, a safe and efficient nano-vector, CRS, was designed and synthesized to facilitate siRNA delivery. …”
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    Design, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery
  3. 56383
    “…While research has largely focused on terrestrial systems, the low soil binding and high water solubility of neonicotinoids, paired with their extensive use on the landscape, puts aquatic environments at high risk for contamination via runoff events. …”
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    Effects of clothianidin on aquatic communities: Evaluating the impacts of lethal and sublethal exposure to neonicotinoids
  4. 56384
    “…In vitro disposition studies to assess solubility, intestinal permeability, and metabolic stability were predictive of good oral bioavailability. …”
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    Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis
  5. 56385
    “…The conjugate was confirmed by matrix-assisted laser desorption time of flight mass spectrometry, (1)H NMR, and (13)C NMR. The water solubility of the prodrug was increased by over 3,000 times; much longer body circulation time, higher tumor-targeting ability, and reduced toxicity were observed, compared with commercial 10-HCPT injection. …”
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    A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting
  6. 56386
    por Stulz, Eugen
    Publicado 2017
    “…This includes particularly problems regarding synthesis of the building blocks, DNA synthesis, yields, solubility, and intermolecular interactions.…”
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    Nanoarchitectonics with Porphyrin Functionalized DNA
  7. 56387
    “…BACKGROUND AND AIMS: Desflurane and sevoflurane have low blood gas solubility co-efficients, allowing a rapid awakening from anaesthesia. …”
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    Desflurane for ambulatory anaesthesia: A comparison with sevoflurane for recovery profile and airway responses
  8. 56388
    “…Within the series, the oxazole derivative KuWei173 showed high potency (IC(50) = 75 nM; 3D7 strain), good solubility in aqueous solvents (1.33 mM), and >100-fold selectivity toward human cell lines. …”
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    Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages
  9. 56389
    “…CONCLUSION: In regard to all advantages of nanobodies; stability, solubility, production affordability in Escherichia coli, and gene tailoring, nanobody-based phage sandwich ELISA developed here would provide a valuable method for hGH detection and quantification.…”
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    Exploiting Nanobodies in the Detection and Quantification of Human Growth Hormone via Phage-Sandwich Enzyme-Linked Immunosorbent Assay
  10. 56390
    por Tao, Huang, Dongwei, Li
    Publicado 2014
    “…The different mineralogy characteristics and the acid solubility of the metal sulfides (e.g., chalcopyrite and pyrite) cause two different dissolution pathways, the thiosulfate and the polysulfide pathways. …”
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    Presentation on mechanisms and applications of chalcopyrite and pyrite bioleaching in biohydrometallurgy – a presentation
  11. 56391
    “…The fermenting microbiome (mainly consisting of Clostridium IV and Lactobacillus) was capable of producing a maximum caproic acid concentration of 10.92 ± 0.62 g L(−1) at pH 5.5, at the border of maximum solubility of protonated caproic acid. CONCLUSIONS: Grass can be utilized as a substrate to produce caproic acid. …”
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    Electricity-assisted production of caproic acid from grass
  12. 56392
    “…Despite its important beneficial properties, it has a low water solubility, which limits its therapeutic applications in humans. …”
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    Biological effects of combined resveratrol and vitamin D3 on ovarian tissue
  13. 56393
    “…CONCLUSION: The properties of the NO-releasing chitosan, including water solubility, make it an excellent drug candidate for treating respiratory infections. …”
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    Nitric Oxide-Releasing Chitosan for the Treatment of Multi-Drug Resistant Superbugs
  14. 56394
    “…The goal of the current study was to explore the potential benefits of Acitretin (Act) nanovesicular gel as a prospective antipsoriatic topical delivery system counteracting the drug challenges in terms of its extremely low aqueous solubility, instability, skin irritation, and serious systemic adverse effects. …”
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    Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo–in vivo evaluation study
  15. 56395
    “…However, betulin’s in vivo biological effectiveness is limited by its poor solubility. As such, we synthesized polar glycosylated derivatives to increase its hydrosolubility and enhance its pharmacological properties. …”
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    Bidesmosidic betulin saponin bearing L-rhamnopyranoside moieties induces apoptosis and inhibition of lung cancer cells growth in vitro and in vivo
  16. 56396
    “…Non-structural carbohydrates concentrations were manipulated substituting dried distiller grain with solubles and alfalfa hay for flaked corn. Cattle were weighed every 112 days and at the end of the experiment (day 308) when the cattle were harvested and carcass characteristics were evaluated. …”
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    Influence of dietary nonstructural carbohydrate concentration on growth performance and carcass characteristics of Holstein steers
  17. 56397
    “…The results showed as follows: 1) ADF was significantly affected by barrel temperature (P < 0.05); the optimum extrusion parameters were barrel temperature 125 °C, moisture content 16% and feed rate 9 Hz. 2) Raw material extrusion and steam conditioning both significantly decreased powder percentage, pulverization ratio and protein solubility (P < 0.05), significantly improved hardness and starch gelatinization degree of rabbit feed (P < 0.05). …”
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    Effects of raw material extrusion and steam conditioning on feed pellet quality and nutrient digestibility of growing meat rabbits
  18. 56398
    por Cohrs, Imke, Grünberg, Walter
    Publicado 2018
    “…Despite important differences in solubility of NaH(2)PO(4) and Na(2)HPO(4) only small plasma [Pi] differences were observed after treatment.…”
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    Suitability of oral administration of monosodium phosphate, disodium phosphate, and magnesium phosphate for the rapid correction of hypophosphatemia in cattle
  19. 56399
    “…RESULTS: At pH 1.2, LDH was dissolved and intercalated antibiotic released from ZnAl-CD in a molecular form, which led to a significant increase in the antibiotic’s solubility. Results showed that the release of drug from nanohybrid at pH 4.0, 6.8 and 7.4 was a sustained process. …”
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    Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide
  20. 56400
    “…Methods: Six polyphenolic fractions were derived from the total polyphenolic extract of dried plum based on solubility. Initial screening, with the use of the Raw 264.7 monocyte and macrophage cell line, showed that 3 fractions had the most marked capacity to downregulate osteoclast differentiation. …”
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    Osteoclast Differentiation is Downregulated by Select Polyphenolic Fractions from Dried Plum via Suppression of MAPKs and Nfatc1 in Mouse C57BL/6 Primary Bone Marrow Cells
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