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  1. 56501
    “…Protein glycosylation can be important for a variety of reasons including protein function, solubility, protease resistance, and thermodynamic stability. …”
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    Characterization of the O-Glycoproteome of Porphyromonas gingivalis
  2. 56502
    “…Furthermore, to improve the aqueous solubility of MBZ, it was formulated in the form of mixed micelles (MMs) which showed an enhanced drug release with better promising cytotoxicity results compared to the crude MBZ. …”
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    In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity
  3. 56503
    “…CPT-loaded polyphosphazenes formed 140–200 nm aggregates in simulated body physiological conditions (PBS, pH 7.4), resulting in an 80–100-fold increase of CPT solubility. EPI-loaded polyphosphazenes formed 250 nm aggregates in an aqueous medium. …”
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    Polyphosphazene-Based Nanocarriers for the Release of Camptothecin and Epirubicin
  4. 56504
    “…The datasets were obtained from 3 trial locations (New Zealand, Australia and United States) and collectively incorporated variations in diet composition (feedstuff composition, phytate-P (PP) level, limestone solubility), feed form (mash or pellet), bird genetics (strain), and age at sampling (11–35 d of age). …”
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    Modeling improvements in ileal digestible amino acids by a novel consensus bacterial 6-phytase variant in broilers
  5. 56505
    “…RESULTS: Polymers help improve drug delivery by increasing solubility, controlling pharmacokinetics, and extending release. …”
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    Considerations for Polymers Used in Ocular Drug Delivery
  6. 56506
    “…The predicted epitopes were assessed for allergenicity, antigenicity, virulence, toxicity, and solubility. Moreover, filtered epitopes were utilized in multi-epitope vaccine construction. …”
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    Designing a Recombinant Vaccine against Providencia rettgeri Using Immunoinformatics Approach
  7. 56507
    “…The expression plasmid pET_RTX_(exo-) was transferred to various E. coli genotypes that either compensated for codon bias (Rosetta-gami 2) or contained additional chaperones to promote solubility (BL21 (DE3) with plasmids pKJE8 or pTf2). …”
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    One-Enzyme RTX-PCR for the Detection of RNA Viruses from Multiple Virus Genera and Crop Plants
  8. 56508
    “…The evaluation of the Hansen solubility parameters of G-OH revealed a substantial increase of δ(P) and δ(H) parameters with respect to HSAG. …”
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    Polyhydroxylated Nanosized Graphite as Multifunctional Building Block for Polyurethanes
  9. 56509
    “…Most of the ZOLE-based BPCCs (60–85%, in 18–24 h) present a lower dissolution and equilibrium solubility than ZOLE (∼100%, 30 min) in phosphate buffered saline (PBS), while a significantly higher dissolution is observed in acidic media (88% in 1 h). …”
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    High affinity zoledronate-based metal complex nanocrystals to potentially treat osteolytic metastases
  10. 56510
    “…In a physical property test, firstly, we tested the permeability, solubility, and storage temperature of nano-TiO(2), so as to provide experimental basis for the synthesis of Nano-TiO(2)-DNA sensor. …”
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    TiO(2)-DNA Nanosensor In Situ for Quick Detection of Nasal Flora in Allergic Rhinitis Patients
  11. 56511
    “…Conclusions: Co-administration therapy of GW5074 and sorafenib demonstrated a favorable safety profile and showed anti-tumor activity in a variety of tumor types. However, the solubility of GW5074 is not satisfactory. A future phase 2a trial will be carried out using the new salted form that has been proven to be more effective.…”
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    Phase I Targeted Combination Trial of Sorafenib and GW5074 in Patients with Advanced Refractory Solid Tumors
  12. 56512
    “…The moderate to high water solubility and environmental persistence of neonicotinoids allows these compounds to readily enter, and be retained in, water resources where they may harm nontarget organisms and impact biological communities and associated trophic structures negatively. …”
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    Regional extent, environmental relevance, and spatiotemporal variability of neonicotinoid insecticides detected in Florida’s ambient flowing waters
  13. 56513
    “…This level of solvation diversity correlates with the solubility of the electrolyte, with Zn(TFSI)(2)/THF exhibiting the lowest degree of each. …”
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    Understanding the Solvation-Dependent Properties of Cyclic Ether Multivalent Electrolytes Using High-Field NMR and Quantum Chemistry
  14. 56514
    “…The obtained polymers were also verified to be amorphous copolymers and had high thermal stability, good solubility and optical transparency.…”
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    Bis-(salicylaldehyde-benzhydrylimino)nickel complexes with different electron groups: crystal structure and their catalytic properties toward (co)polymerization of norbornene and 1-hexene
  15. 56515
    “…In the present study, we examined the efficacy of a host–guest ICG–β-cyclodextrin (CD) complex, which is used in pharmaceutics to improve the water solubility, stability, and bioavailability of hydrophobic molecules, for NIR imaging after hind footpad administration in a rat model. …”
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    Host–guest interactions of indocyanine green with β-cyclodextrin permit real-time characterization of the rat lymphatic system
  16. 56516
    “…Trazpiroben, a dopamine D(2)/D(3) receptor antagonist under development to treat gastroparesis, displays decreasing solubility with increasing pH. This single‐sequence, open‐label, two‐period, crossover study evaluated the effect of esomeprazole, a proton pump inhibitor that raises gastric pH, on the single‐dose pharmacokinetics, safety, and tolerability of trazpiroben in healthy adults (NCT03849690). …”
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    Evaluation of the pharmacokinetics of trazpiroben (TAK‐906) in the presence and absence of the proton pump inhibitor esomeprazole
  17. 56517
    por Wang, Shui-Jiong, Li, Shu-Guang
    Publicado 2022
    “…When the dehydrated fluids dissolve carbonate minerals, they may evolve into lighter Mg isotopic compositions. The solubility of carbonate minerals in fluids decreases in the order of calcite, aragonite, dolomite, magnesite and siderite, leading to selective and partial dissolution of carbonate minerals along the subduction path. …”
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    Magnesium isotope geochemistry of the carbonate-silicate system in subduction zones
  18. 56518
    “…Simvastatin (SIM) and ezetimibe (EZE) are commonly used clinically as cholesterol-lowering drugs; however, their treatment efficacy is severely affected by their poor water solubility and low bioavailability. In this study, SIM and EZE were made into a co-amorphous system to improve their dissolution, oral bioavailability, storage stability, and cholesterol-lowering effects. …”
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    Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice
  19. 56519
    “…To increase phytate-P availability in the rhizosphere, plants and microbes have developed strategies to improve phytate solubility and mineralization by secreting mobilizing agents including organic acids and hydrolyzing enzymes including various phytases. …”
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    Enhancing Phytate Availability in Soils and Phytate-P Acquisition by Plants: A Review
  20. 56520
    “…Physicochemical properties, lipophilicity, water solubility, pharmacokinetics, druglikeness and medicinal chemistry were evaluated for four compounds that were more promising, showed negative indices for the potential penetration of the Blood Brain Barrier and expressed high human intestinal absorption, indicating a low risk of central nervous system depression or drowsiness as the the side effects. …”
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    A Computational Approach Applied to the Study of Potential Allosteric Inhibitors Protease NS2B/NS3 from Dengue Virus
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