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  1. 56721
    por Badria, Farid, Mazyed, Eman
    Publicado 2020
    “…AKBA is a potent anti-inflammatory drug, but it has poor oral bioavailability due to its poor aqueous solubility. Moreover, the topical delivery of AKBA is difficult due to its high lipophilicity. …”
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    Formulation of Nanospanlastics as a Promising Approach for ‎Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-‎Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, in vitro ‎Characterization, and ex vivo Permeation Study
  2. 56722
    “…Other chemical and pharmacological properties of this RA were also evaluated, including topological polar surface area (TPSA) = 78.13 Å and solubility (Log S) = −4.8. The probability values of the antineoplastic, anti-free radical activities and topoisomerase I (TopoI) inhibitory activity were found to be 0.784, 0.644 and 0.379, respectively. …”
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    Antitumor Activity and Mechanism of Robustic Acid from Dalbergia benthami Prain via Computational Target Fishing
  3. 56723
    “…Limestone particle size (PS) affects its solubility and thus can influence broiler performance by altering the rate of calcium (Ca) release into the gastrointestinal tract. …”
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    Limestone particle size, calcium and phosphorus levels, and phytase effects on live performance and nutrients digestibility of broilers
  4. 56724
    “…ECM proteins were identified using solubility profiling. Putative targets were validated using immunofluorescence, in vitro degradation assays, co-immunoprecipitation, and Förster resonance energy transfer (FRET)-based protein-protein interaction assays. …”
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    ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1
  5. 56725
    “…The NC and PC pigs were fed the same control diet, containing 20% corn distillers dried grains with solubles (DDGS). The RS pigs were fed a diet formulated with 5% sugar beet pulp and 5% resistant potato starch. …”
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    Brachyspira hyodysenteriae Infection Reduces Digestive Function but Not Intestinal Integrity in Growing Pigs While Disease Onset Can Be Mitigated by Reducing Insoluble Fiber
  6. 56726
    “…The second analogue offered advantages as solubility in aqueous solution and potential lower steric hindrance for both intended interactions, with the protein and with avidin. …”
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    Biotin-Labelled Clavulanic Acid to Identify Proteins Target for Haptenation in Serum: Implications in Allergy Studies
  7. 56727
    “…This experiment evaluated the interactive effects among xylanase (XL; 0, 8,000, 16,000, and 32,000 BXU/kg), amino acid density (AA; high and low 10% difference), and additional fat (AF; 0 or +1.17%) applied postpellet in corn-soybean meal diets with dried distillers grains with solubles on performance, energy utilization, digestibility, and carcass traits in Ross 708 male broilers. …”
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    Effects of graded levels of exogenous xylanase in corn-soy diets with two amino acid density and fat levels postpellet in broiler chickens: live performance, energy utilization, digestibility, and carcass characteristics
  8. 56728
    “…Curcumin's (Cur) low water solubility and low bioavailability are the biggest obstacles to effective use of curcumin for anticancer therapy, and these obstacles can be overcome by utilizing an efficient delivery system. …”
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    Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment
  9. 56729
    por Kardani, Kimia, Bolhassani, Azam
    Publicado 2021
    “…Next, the physicochemical properties of the predicted CPPs including net charge, theoretical isoelectric point (pI), amphipathicity, molecular weight, and water solubility were calculated using protparam and pepcalc tools. …”
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    Exploring novel and potent cell penetrating peptides in the proteome of SARS-COV-2 using bioinformatics approaches
  10. 56730
    “…However, its sparingly aqueous solubility and limited gastrointestinal permeability lead to scanty oral bioavailability which hinders its clinical efficacy. …”
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    Precisely Fabricated Sulpiride-Loaded Nanolipospheres with Ameliorated Oral Bioavailability and Antidepressant Activity
  11. 56731
    “…Reactions are more often caused by inert substances, called excipients, which are added to vaccines to improve stability and absorption, increase solubility, influence palatability, or create a distinctive appearance, and not by the active vaccine itself. …”
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    Allergic Reactions to Current Available COVID-19 Vaccinations: Pathophysiology, Causality, and Therapeutic Considerations
  12. 56732
    “…PURPOSE: Eplerenone (EPL) is a selective mineralocorticoid receptor antagonist used for treatment of chronic central serous chorioretinopathy which characterized by accumulation of subretinal fluid causing a localized area of retinal detachment. unfortunately, EPL suffers from poor oral bioavailability due to poor aqueous solubility in addition to high hepatic first pass metabolism. …”
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    Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment
  13. 56733
    “…The increased (p < 0.05) solubility of the protein fraction along with the remarkably higher (p < 0.05) anserine content found in GRW I + II suggests an increased energy requirement in the pectoral muscles belonging to lysine-restricted birds and supports the hypothesis of a reduced protein synthesis taking place within these muscles.…”
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    Lysine Depletion during Different Feeding Phases: Effects on Growth Performances and Meat Quality of Broiler Chickens
  14. 56734
    “…We conducted a hydroponic experiment to examine the impact of pH on cadmium (Cd) solubility and bioavailability in winter wheat (Triticum aestivum L.) under controlled environmental conditions. …”
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    The interactive effect of pH variation and cadmium stress on wheat (Triticum aestivum L.) growth, physiological and biochemical parameters
  15. 56735
    “…ABSTRACT: In the present investigation, N retention, AME, and AMEn data from six energy evaluation assays, involving four protein sources (soybean meal, full-fat soybean, rapeseed meal and maize distiller’s dried grains with solubles [DDGS]), are reported. The correction for zero N retention, reduced the AME value of soybean meal samples from different origins from 9.9 to 17.8% with increasing N retention. …”
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    Application of Apparent Metabolizable Energy versus Nitrogen-Corrected Apparent Metabolizable Energy in Poultry Feed Formulations: A Continuing Conundrum
  16. 56736
    por Oh, Soojin, Cave, Gareth, Lu, Chungui
    Publicado 2021
    “…This is mainly because nanoparticles have better solubility and permeability due to their nano size with high surface exposure. …”
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    Vitamin B(12) (Cobalamin) and Micronutrient Fortification in Food Crops Using Nanoparticle Technology
  17. 56737
    “…Daily supplements [0.45 kg/d of cottonseed meal (Control) enough to avoid a negative ruminal N balance; and 0.50% mean paddock BW animal-daily (approximately 1.65 kg) of sorghum-dried distillers grains plus solubles, (DDGS)] were randomly assigned to two paddocks each. …”
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    Teff grass for continuous stocking in the Southern High Plains by growing beef steers receiving protein supplements()
  18. 56738
    “…Chitosan/tripolyphosphate (TPP) nanoparticles were selected for this study due to their biocompatibility, biodegradability and capacity to overcome the problem of low solubility of GRP in physiological conditions. This study aims to produce and characterise chitosan/TPP nanoparticles as GRP-delivery vehicles and test its anti-inflammatory potential in human macrophages. …”
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    Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)
  19. 56739
    “…When the corn was compared as dry-rolled corn in diets with lower inclusion rates of distiller grains plus solubles (less than 20% of the diet), feeding Enogen(®) corn improved the efficiency of beef production. …”
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    Impact of Feeding Syngenta Enogen(®) Feed Corn Compared to Control Corn in Different Diet Scenarios to Finishing Beef Cattle
  20. 56740
    “…The purpose of this study is to design a flower-shaped lactose loaded curcumin solid lipid nanoparticles dry powder inhaler and characterize it to improve the solubility and dissolution rate of curcumin in lung. …”
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    Preparation of Curcumin Solid Lipid Nanoparticles Loaded with Flower-Shaped Lactose for Lung Inhalation and Preliminary Evaluation of Cytotoxicity In Vitro
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