“…However, MBZ exhibits low solubility, limited absorption efficacy, extensive first-pass effect, and low bioavailability. …”
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“…Iron is an essential micronutrient for living organisms, but its solubility is extremely low under alkaline conditions. …”
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“…Being the member of BCS class II drugs, ALP has solubility problem, which affects its bioavailability. …”
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“…We rationally evaluate approaches to increase both the kinetic corrosion rate and the thermodynamic solubility of Al(0) and Cu(0), and evaluate the impact of these treatment conditions on the structure, chemistry, and electrochemical performance of NMC. …”
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“…Important information is the lattice location of these atoms, how many of them can be introduced to the lattice (solubility). Thus it can be determined if these elements are suited as dopants. …”
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“…Four formulation strategies were tested including (1) a pellet containing feeds commonly included in the concentrate mixture of a total mixed ration, including 43.1% corn grain, 26.3% dried distillers grains, 3.18% soybean meal, and 5.6% vitamin and mineral premix (CMIX), (2) a pellet of dry corn gluten feed (CGF), (3) a pellet including feedstuffs that are considered to be highly palatable (53.2% wheat middling, 15.7% dried corn distillers grains and solubles, 15.2% cane molasses, and 1.81% oregano (FLVR), and (4) a high-energy pellet (ENG) consisting of 61% corn grain and 26.2% wheat middlings. …”
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“…In experiment 1, four 4-phase growing-finishing feeding programs consisting of diets containing corn and soybean meal (CSBM), low protein CSBM supplemented with crystalline amino acids (LP), CSBM with 30% distillers dried grains with solubles (DDGS), and DDGS supplemented with crystalline Ile, Val, and Trp (DDGS + IVT) were fed to 288 mixed sex pigs (initial body weight [BW] = 36.9 ± 4.2 kg) for 12 wk to determine effects on growth performance and carcass characteristics. …”
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“…RESULTS: Based on the initial screening results, the omp25 protein was identified for immunogenicity because it had the maximum solubility and flexibility and antigenic values of 0.75. …”
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“…Anthocyanin O-methyltransferases (AOMTs) are an important group of enzymes that have the ability to catalyze anthocyanins methylation to promote the solubility, stability, and bioactivity of anthocyanins. …”
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“…In in silico ADME prediction, ALC was shown to have poor water solubility and high gastrointestinal absorption along with inhibition of some cytochrome P450s (CYP2C19 and CYP2C9) without inhibition of others (CYP1A2, CYP3A4, and CYP2D6) and P-glycoprotein substrate. …”
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“…The S:F ratio of the diet was manipulated by replacing the corn grain by dried distillers grain with solubles and roughage. Urea combination did not affect ruminal pH. …”
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“…Furthermore, it has been evaluated that the 12 ginger components possessed a favorable ADMET profiles with regard to the solubility, absorption, permeability across the blood–brain barrier, interactions with CYP2D6, hepatotoxicity, and plasma protein binding. …”
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“…Similarly, free radicals are implicated in the progression of various diseases like neurodegenerative disorders. Due to lipid solubility and potential to easily cross blood brain barrier, this study was designed to investigate the anticholinesterase and antioxidant potentials of the standardized essential oils from the leaves and flowers of Polygonum hydropiper. …”
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“…While several studies identified specific particle characteristics driving respiratory toxicity of low-solubility and low-toxicity particles such as CNP, the major lung cell type, which initiates and drives that response, remains still uncertain. …”
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“…Attachment of PEG to the SMR peptide, termed PEGylation, offers improved water solubility and stability as well as reduced clearance through the kidneys, leading to a longer circulation time. …”
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“…The peptide sequence can be designed to form β-sheets among the amino acids near the alkyl tail, while the residues farthest from the tail are charged to promote solubility and in some cases contain a bioactive sequence. …”
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“…Scale-up of this technology for fuels applications has resulted in a massive supply of distillers’ grains with solubles (DGS) coproduct, which is rich in cellulosic polysaccharides and protein. …”
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“…In silico and PK studies suggested that the absorption of these alkaloids, except QPAs, mainly depended on their solubility rather than permeability; Thirdly, EF could promote the absorption and accelerate the elimination of QPAs, and had a greater influence on the former than the latter. …”
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“…METHODS: 2-Phenoxyethanol (2-POE) was selected as a surrogate based on its water solubility, Henry’s volatility constant, detectability by mass spectrometry, and non-toxicity. …”
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“…The diets were based on corn, soybean meal, corn distillers dried grains with solubles (DDGS), and wheat middlings. Pigs had 7 d to adapt to the environment and consumed the same commercial diet. …”
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