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  1. 121
    “…With the improved assay, quantification of condensed tannins in water-soluble forms was highly replicable. The relative abundance of condensed tannins in soluble and insoluble forms differed substantially between tissue types. …”
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    An improved butanol-HCl assay for quantification of water-soluble, acetone:methanol-soluble, and insoluble proanthocyanidins (condensed tannins)
  2. 122
    “…[Image: see text] Water-soluble pillar[6]arene (WP6) was used to solubilize camptothecin family antitumor drugs. …”
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    Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene
  3. 123
    “…In the present study, the screening of Mirabegron (MBR) co-amorphous was performed to produce water-soluble and thermodynamically stable MBR co-amorphous with the purpose of overcoming the water solubility problem of MBR. …”
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    Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors
  4. 124
    “…However, its poor water solubility and low bioavailability limit its clinical application and development. …”
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    Highly Water-Soluble Solid Dispersions of Honokiol: Preparation, Solubility, and Bioavailability Studies and Anti-Tumor Activity Evaluation
  5. 125
    “…There is growing evidence that in vitro drug solubility may underestimate the true in vivo solubility and lead to drug misclassification. …”
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    Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling
  6. 126
    “…BACKGROUND: Although the soluble form of suppression of tumorigenicity 2 (sST2) and soluble low-density lipoprotein receptor relative with 11 ligand-binding repeats (sLR11) have emerged as novel cardiovascular biomarkers in patients with cardiovascular disease, their prognostic value has not been fully investigated in peritoneal dialysis (PD) patients. …”
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    Prognostic value of soluble ST2 and soluble LR11 on mortality and cardiovascular events in peritoneal dialysis patients
  7. 127
    “…In this study, we identify a short 15-residue enhancing solubility peptide, the PCDS (protocatechuate 3,4-dioxygenase solubility) tag, which enhances heterologous protein expression in E. coli. …”
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    The Protocatechuate 3,4-Dioxygenase Solubility (PCDS) Tag Enhances the Expression and Solubility of Heterogenous Proteins in Escherichia coli
  8. 128
    “…Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. …”
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    Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition
  9. 129
    “…Based on this concept, collagens such as acid-soluble (ASC) and pepsin-soluble (PSC) were extracted from a new type of cartilaginous fish, the blacktip reef shark, for the first time, and were further investigated for physicochemical, protein pattern, microstructural and peptide mapping. …”
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    Comparison of Physicochemical and Structural Properties of Acid-Soluble and Pepsin-Soluble Collagens from Blacktip Reef Shark Skin
  10. 130
    “…A high percentage of marketed drugs suffer from poor water solubility and require an appropriate technique to increase their solubility. …”
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    Solubility enhancement of some poorly soluble drugs by solid dispersion using Ziziphus spina-christi gum polymer
  11. 131
    “…Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. …”
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    The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character
  12. 132
    por Craigie, James, Wishart, F. O.
    Publicado 1936
    “…Thermolabile and thermostable soluble precipitable substances dissociate in vitro from the elementary bodies of vaccinia. 2. …”
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    STUDIES ON THE SOLUBLE PRECIPITABLE SUBSTANCES OF VACCINIA : I. THE DISSOCIATION IN VITRO OF SOLUBLE PRECIPITABLE SUBSTANCES FROM ELEMENTARY BODIES OF VACCINIA
  13. 133
    “…Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. …”
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    THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY
  14. 134
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    Matrix metalloproteinase-1, soluble Fas ligand, and soluble Fas antigen levels in patients with multiple organ dysfunction syndrome
  15. 135
    “…Amorphous solid dispersions (ASDs) are a promising formulation approach for poorly soluble active pharmaceutical ingredients (APIs), because they ideally enhance both dissolution rate and solubility. …”
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    The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility
  16. 136
    “…The objective of this study was to evaluate health outcomes resulting from dietary supplementation of novel, low-digestible carbohydrates in the cecum and colon of Sprague-Dawley rats randomly assigned to one of four treatment groups for 21 days: 5% cellulose (Control), Pectin, soluble fiber dextrin (SFD), or soluble corn fiber (SCF). …”
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    Soluble Fiber Dextrin and Soluble Corn Fiber Supplementation Modify Indices of Health in Cecum and Colon of Sprague-Dawley Rats
  17. 137
    “…This review mainly discusses classification, methods for preparation of solid dispersions, and use of solid dispersion for improving solubility of poorly soluble anticancer drugs.…”
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    Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs
  18. 138
    por Martir, J., Flanagan, T., Mann, J., Fotaki, N.
    Publicado 2020
    “…However, the impact of this practice on drug solubility and on oral drug bioavailability is not usually studied. …”
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    Impact of Food and Drink Administration Vehicles on Paediatric Formulation Performance: Part 1—Effects on Solubility of Poorly Soluble Drugs
  19. 139
    “…Lung burden measurements are particularly relevant when the testing chemical is a solid poorly soluble nanomaterial. Previously, the current authors showed that total retained lung burden of inhaled soluble silver nanoparticles (AgNPs) could be effectively measured using any individual lung lobe. …”
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    Even lobar deposition of poorly soluble gold nanoparticles (AuNPs) is similar to that of soluble silver nanoparticles (AgNPs)
  20. 140
    “…The formations of different polymorphs was observed, showing that their solubility is not a function of their structure. The kinetics of the transformation can give misleading solubility values according to Ostwald’s rule. …”
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    Aqueous Solubility of Organic Compounds for Flow Battery Applications: Symmetry and Counter Ion Design to Avoid Low-Solubility Polymorphs
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