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  1. 1501
    “…Belonging to the class of so-called soluble guanylate cyclase (sGC) activators, cinaciguat and BAY 60-2770 are interesting therapeutic tools for the treatment of various cardiovascular pathologies. …”
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    Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat
  2. 1502
    “…BACKGROUND: Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. …”
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    Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury
  3. 1503
    por Fan, Xing, Wang, Fei
    Publicado 2018
    “…The results showed that most of organic compounds in coals were converted into water-soluble species under mild conditions, even the anthracite. …”
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    Molecular Distributions of Soluble Oxidation Products from Coals Characterized by Mass Spectrometers
  4. 1504
    “…If PI resistance can be overcome, these drugs may prove even more useful to a greater range of patients. Both soluble and insoluble (contact mediated) signals drive PI-resistance via activation of various intracellular signaling pathways. …”
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    Soluble and Cell–Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma
  5. 1505
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    Airway Relaxation Effects of Water-Soluble Sclerotial Extract From Lignosus rhinocerotis
  6. 1506
    “…This study indicates that both GDNF and soluble APPα represent possible biomarkers for ALS.…”
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    A Role for GDNF and Soluble APP as Biomarkers of Amyotrophic Lateral Sclerosis Pathophysiology
  7. 1507
    “…In principle, tissue extravasation can be limited through shedding of CD18 integrins from leukocytes, including monocytes. The soluble (s) product sCD18 conceals adhesion receptors on the endothelium, which reduces monocyte extravasation. …”
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    Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis
  8. 1508
    “…Here we describe the construction and characterization of a new soluble TRAIL, sfTRAIL, stabilized with the trimerization Foldon domain from the Fibritin protein of the bacteriophage T4. …”
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    Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations
  9. 1509
    “…[Image: see text] The solubility of CO(2) in hydrophobic deep eutectic solvents (DESs) has been measured for the first time. …”
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    Carbon Dioxide Solubilities in Decanoic Acid-Based Hydrophobic Deep Eutectic Solvents
  10. 1510
    “…In previous studies, Lactobacillus rhamnosus GG (LGG) soluble mediators (LSM) have been demonstrated to exert beneficial effects in preclinical models of allergic sensitization, bacterial infection, and intestinal barrier function. …”
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    Lactobacillus rhamnosus GG-Derived Soluble Mediators Modulate Adaptive Immune Cells
  11. 1511
    “…However, despite its widespread use, the mechanism underlying the decreased solubility of MPC that occurs during storage has not yet been clarified. …”
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    Protein cross‐linking and the Maillard reaction decrease the solubility of milk protein concentrates
  12. 1512
    “…Trichloroethylene showed a highest toxicity to luminescent bacteria, while chlorobenzene had the lowest toxicity. Water-soluble UV photodegradation products for styrene are very toxic to Daphnia magna. …”
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    Biotoxicity of Water-Soluble UV Photodegradation Products for 10 Typical Gaseous VOCs
  13. 1513
    “…The inhibitory effect of the NO donor was eliminated under blockade of soluble guanylate cyclase with a specific inhibitor ODQ. …”
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    Soluble Guanylate Cyclase As the Key Enzyme in the Modulating Effect of NO on Metabotropic Glutamate Receptors
  14. 1514
    “…This study explored the effects of probucol on atherosclerotic plaques and soluble thrombomodulin in patients with coronary heart disease (CHD). …”
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    Effects of probucol on atherosclerotic plaque and soluble thrombomodulin in patients with coronary heart disease
  15. 1515
    “…BACKGROUND: Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. …”
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    Clinical significance of serum soluble B7-H3 in patients with osteosarcoma
  16. 1516
    “…AIM: To investigate how smoking influence the levels of soluble PD-1 ligand (sPD-L1). METHOD: Serum levels of sPD-L1 were measured in 246 RA patients and in 168 healthy subjects. …”
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    Smoking Is Associated With Low Levels of Soluble PD-L1 in Rheumatoid Arthritis
  17. 1517
    “…Circulating levels of all three were associated with gene variants at the soluble epoxide hydrolase enzyme. Lipidomic profiling in SF identified an additional inflammatory pathway associated with knee OA and radiographic progression.…”
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    Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis
  18. 1518
    “…More specifically, we separated entries to compare soluble vs membrane proteins, and further separated the later in subcategories according to their insertion in the membrane, function, or type of crystallization (Type I vs Type II crystal packing). …”
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    Au courant computation of the PDB to audit diffraction anisotropy of soluble and membrane proteins
  19. 1519
    “…Novel dispersion techniques are highly encouraged to develop for formulation of poorly water-soluble drugs.…”
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    Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
  20. 1520
    “…Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous solubility. …”
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    Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
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