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  1. 1621
    “…For CD33 (Siglec-3), we demonstrate that it recognizes both α2-3 and α2-6 sialosides in solution and on cells, which has implications for its link to Alzheimer’s disease susceptibility. These soluble Siglecs reveal the abundance of their glycan ligands on host cells as self-associated molecular patterns.…”
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    A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands
  2. 1622
    por Li, Long, Yin, Xian-Hong, Diao, Kai-Sheng
    Publicado 2020
    “…[Image: see text] Pemafibrate is a new generation of anti-hyperlipidemia drugs. However, its poor solubility in water (0.410 mg/mL at 25 °C) has limited its oral bioavailability. …”
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    Improving the Solubility and Bioavailability of Pemafibrate via a New Polymorph Form II
  3. 1623
    “…In the present study, we performed membrane assays to compare the self-inhibitory effects of soluble metabolites produced by several Trichoderma isolates and their antifungal activity against a phytopathogenic strain of Fusarium oxysporum. …”
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    Self-Inhibitory Activity of Trichoderma Soluble Metabolites and Their Antifungal Effects on Fusarium oxysporum
  4. 1624
    “…This survival requires cytosolic abundant heat soluble (CAHS) proteins. CAHS D protects enzymes from desiccation- and lyophilization-induced inactivation in vitro and has the potential to stabilize protein-based therapeutics, including vaccines. …”
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    Toxicity and Immunogenicity of a Tardigrade Cytosolic Abundant Heat Soluble Protein in Mice
  5. 1625
    “…Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mechanically and thermally intensive processes is not straightforward in the cases of ductile and/or low melting point substances that may additionally be susceptible to eutectic formation. …”
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    Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation
  6. 1626
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    In Vitro Prebiotic Effects of Malto-Oligosaccharides Containing Water-Soluble Dietary Fiber
  7. 1627
    “…Previous studies aiming to validate aggregated tau pathology as a pathogenic driver of neurodegeneration in correlation to characteristic behavioral phenotypes have had shortcomings. Although studies on soluble tau pathology have effectively addressed these shortcomings, the role of soluble tau in the molecular pathogenesis of neurodegeneration is not yet unequivocally established. …”
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    Soluble 4R0N Tau Abrogates Endocytic Vesicular Dynamics
  8. 1628
    “…In addition to suggesting an interaction between the metabolism of proline and that of soluble sugars, results broaden our understanding of the predominant role played by the accumulation of soluble sugars in counteracting mild osmotic stress. …”
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    Impact of Drought on Soluble Sugars and Free Proline Content in Selected Arabidopsis Mutants
  9. 1629
    “…The AuNPs synthesized in the presence of water-soluble polymers were stable over a period of 36 days. …”
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    Synthesis and Stabilization of Gold Nanoparticles Using Water-Soluble Synthetic and Natural Polymers
  10. 1630
    “…The equilibrium solubility of amygdalin in [ethanol (1) + water (2)] mixtures at 293.15 K to 328.15 K was reported. …”
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    Solubility, Solution Thermodynamics, and Preferential Solvation of Amygdalin in Ethanol + Water Solvent Mixtures
  11. 1631
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    Expression of soluble, active, fluorescently tagged hephaestin in COS and CHO cell lines
  12. 1632
    “…In this study, we aimed to investigate the clinical significance of plasma soluble PDPN (sPDPN) levels in patients with breast cancer and its significance in the diagnosis and metastasis. …”
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    The Detection of Plasma Soluble Podoplanin of Patients with Breast Cancer and Its Clinical Signification
  13. 1633
    “…However, their molecular mechanisms of action remain largely unknown. Soluble epoxide hydrolase (sEH) rapidly converts EpFAs into less bioactive fatty acid diols in vivo; therefore, inhibition of sEH is an emerging therapeutic target to enhance the beneficial effect of natural EpFAs. …”
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    Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence
  14. 1634
    “…Soluble amyloid-beta oligomers (Aβo) start to accumulate in the human brain one to two decades before any clinical symptoms of Alzheimer's disease (AD) and are implicated in synapse loss, one of the best predictors of memory decline that characterize the illness. …”
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    Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease
  15. 1635
    “…Here, we review the existing literature on soluble CD163 and soluble mannose receptor in liver diseases with a particular focus on their relationship to hepatic fibrosis in metabolic associated fatty liver disease, as well as in chronic hepatitis B and C.…”
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    Macrophage Activation Markers, Soluble CD163 and Mannose Receptor, in Liver Fibrosis
  16. 1636
    “…The synthesis of a highly soluble triptycene end‐capped indigo and its bay annulated derivative is reported. …”
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    Triptycene End‐Capped Indigo Derivatives – Turning Insoluble Pigments to Soluble Dyes
  17. 1637
    “…Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory mediator associated with the presence of single-territorial atherosclerosis. …”
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    The Proinflammatory Soluble CD40 Ligand Is Associated with the Systemic Extent of Stable Atherosclerosis
  18. 1638
    “…In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuvant agents for the treatment of this condition. …”
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    Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer
  19. 1639
    “…BACKGROUND & AIMS: Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly expressed in the liver and is implicated in hepatic function, but its role in ALD is mostly unexplored. …”
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    Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease
  20. 1640
    “…Efavirenz is also used in paediatrics, but due to its very poor aqueous solubility the liquid formulations available resort to oil-based excipients. …”
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    Inclusion Compound of Efavirenz and γ-Cyclodextrin: Solid State Studies and Effect on Solubility
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