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  1. 1701
    por Ye, Zhuyifan, Ouyang, Defang
    Publicado 2021
    “…Rapid solvent selection is of great significance in chemistry. However, solubility prediction remains a crucial challenge. This study aimed to develop machine learning models that can accurately predict compound solubility in organic solvents. …”
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    Prediction of small-molecule compound solubility in organic solvents by machine learning algorithms
  2. 1702
    “…The solubilities of clemastine fumarate in supercritical carbon dioxide (ScCO(2)) were measured for the first time at temperature (308 to 338 K) and pressure (12 to 27 MPa). …”
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    Measurement and modeling of clemastine fumarate (antihistamine drug) solubility in supercritical carbon dioxide
  3. 1703
    por Nasri, Loubna
    Publicado 2021
    “…The unavailability of experimental values of solute’s sublimation pressure presents one of the major obstacles to the solubility modeling with this type of models, and thus, its estimation is essential and inevitable. …”
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    Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited
  4. 1704
    “…In this study we analyzed the functionality of soluble epoxide hydrolases (sEHs) tunnel network, by comparing the overall enzyme structure with the tunnel’s shape and size. sEHs were divided into three groups based on their structure and the tunnel usage. …”
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    Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network
  5. 1705
    “…The soluble epoxide hydrolase (sEH) enzyme is a major regulator of bioactive lipids. …”
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    Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation
  6. 1706
    “…Water-solubility helps drugs to dissolve in body fluids and be transported to the target location. …”
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    Amikacin potentiator activity of zinc complexed to a pyrithione derivative with enhanced solubility
  7. 1707
    “…Anti-viral and anti-inflammatory agents have shown limited therapeutic efficacy. Soluble CD24 (CD24Fc) blunts the broad inflammatory response induced by damage-associated molecular patterns via binding to extracellular high mobility group box 1 and heat shock proteins, as well as regulating the downstream Siglec10-Src homology 2 domain–containing phosphatase 1 pathway. …”
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    Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology
  8. 1708
    “…While none of the materials was soluble at neutral pH in artificial alveolar fluid (AAF), Cu, CuO, and Ni-based materials displayed distinct dissolution under the acidic conditions found in artificial lysosomal fluids (ALF and PSF). …”
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    Comparison of Metal-Based Nanoparticles and Nanowires: Solubility, Reactivity, Bioavailability and Cellular Toxicity
  9. 1709
    “…Descriptors derived from atomic structure and quantum chemical calculations for small molecules representing polymer repeat elements were evaluated for machine learning models to predict the Hildebrand solubility parameters of the corresponding polymers. …”
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    Atomistic Descriptors for Machine Learning Models of Solubility Parameters for Small Molecules and Polymers
  10. 1710
    “…However, their expression and purification pose difficulties because of their poor water solubilities, which impedes progress in this field. The QTY method, a code-based protein-engineering approach, was recently developed to produce soluble transmembrane proteins. …”
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    Enabling QTY Server for Designing Water-Soluble α-Helical Transmembrane Proteins
  11. 1711
    “…After oral administration, a drug’s solubility in intestinal fluid is an important parameter influencing bioavailability and if the value is known it can be applied to estimate multiple biopharmaceutical parameters including the solubility limited absorbable dose. …”
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    Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems
  12. 1712
    “…A cross-sectional study of 9976 respondents ≥ 18 years old from the US National Health and Nutrition Examination Survey (2007–2012) by utilizing their soluble Klotho protein concentrations. Multivariate linear regression models were used to analyze the effect of soluble Klotho protein on the prevalence of metabolic syndrome. …”
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    Association between Soluble α-Klotho Protein and Metabolic Syndrome in the Adult Population
  13. 1713
    “…Due to an efficient preparation technique, as well as its enhanced solubility, excellent physicochemical properties, improved dissolution and non-toxic nature, nanosponges could be an efficient and a promising approach for the oral delivery of poorly soluble drugs.…”
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    Synthesis and Characterization of Carboxymethyl Chitosan Nanosponges with Cyclodextrin Blends for Drug Solubility Improvement
  14. 1714
    “…The cocrystal was formed by two drug molecules at a molar ratio of 1:1, which contained O–H–O hydrogen bonds between the carbonyl and ether oxygen of PIP and the phenolic hydroxyl group of HES. In addition, a solubility experiment was performed on powder cocrystal in simulated gastrointestinal fluid, and the result revealed that the cocrystal improves the dissolution behavior of HES compared with that of the pure substance. …”
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    Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer
  15. 1715
    “…The HLA-G gene encodes either membrane-bound or/and soluble proteins. The aim of this study was the evaluation of HLA-G polymorphisms and their impact on soluble HLA-G (sHLA-G) production. …”
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    The Association of HLA-G Gene Polymorphism and Its Soluble Form With Male Infertility
  16. 1716
    “…Increased soluble endoglin (sENG) has been observed in human brain arteriovenous malformations (bAVMs). …”
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    Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction
  17. 1717
    “…A series of soluble aromatic poly(amide-imide)s (PAIs) was prepared from a new diamide–diamine monomer having biphenyl units with two CF(3) groups. …”
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    Soluble Poly(amide-imide)s from Diamide–Diamine Monomer with Trifluoromethyl Groups
  18. 1718
    “…Kinetic studies, using absorption spectroscopy, have established that PDI formation proceeds via fast amic acid formation, followed by a slow conversion to imides. Solubility of the intermediate PAA salts is found to be low and rate-limiting. …”
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    Room temperature synthesis of perylene diimides facilitated by high amic acid solubility
  19. 1719
    “…Treatment of CF cells with l-phenylalanine (L-Phe), an activator of CA activity, restores endosomal transport through an effect on microtubule regulation in a manner dependent on soluble adenylate cyclase (sAC). This effect can be blocked with the CA2-selective inhibitor dorzolamide. …”
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    Carbonic anhydrase and soluble adenylate cyclase regulation of cystic fibrosis cellular phenotypes
  20. 1720
    “…The mean particle size in the redispersions of the IRB-NP tablet was approximately 118 nm. The solubility and intestinal absorption of IRB in the IRB-NP tablet were significantly enhanced in comparison with the microcrystalline IRB tablet (IRB-MP tablet), and both solubility and clathrin-dependent endocytosis helped improve the low BA of the IRB. …”
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    Oral Formulation Based on Irbesartan Nanocrystals Improve Drug Solubility, Absorbability, and Efficacy
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