“…During this process, CBL10 interacts with the CBL-interacting protein kinase 24 (CIPK24, SOS2), this interaction being localized at both the plasma and vacuolar (tonoplast) membranes. …”
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“…As a real-world case study, we used OIPCQ to reconstruct SOS DNA network obtained from Escherichia coli and GRN for acute myeloid leukemia based on the RNA sequencing data from The Cancer Genome Atlas. …”
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“…While these features were originally developed for the purposes of a public health and science literacy project, they are now available to all project leaders setting up projects on Anecdata.org and have been adopted by a number of projects, including Mass Audubon’s Eastern Meadowlark Survey, South Carolina Aquarium’s SeaRise, and Coastal Signs of the Seasons (SOS) Monitoring projects.…”
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“…Somatic variants in candidate driver genes (ECD, NUP98, LRP1B, NCOR1, ATM, SOS1, and SPOP) and fusions were described. NCOR1 and SPOP variants underwent validation. …”
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“…Initially, we boosted the expression of 17 candidate trimers by truncating gp41 and introducing a gp120-gp41 SOS disulfide to prevent gp120 shedding. "Repairs" were made to fill glycan holes and eliminate other strain-specific aberrations. …”
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“…Based on the results, GRNN had better performance than MLP or ANFIS and was consequently selected to link different optimization algorithms [genetic algorithm (GA), biogeography-based optimization (BBO), interior search algorithm (ISA), and symbiotic organisms search (SOS)] for prediction of optimal light levels (quality/intensity) and sucrose concentration for various applications. …”
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“…In S. salsa community, transportation of K to aboveground parts of plants helps to maintain high K(+) and low Na(+) concentrations whereas the accumulation of Ca triggers the salt overly sensitive (SOS)-Na(+) system to efflux Na(+). In P. tenuiflora community, enrichment of Mn in roots elevates the level of Mn-superoxide dismutase (SOD) and increases the resistance to saline–alkali stress. …”
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“…And, thymol improved Na(+) efflux and the expression of SOS1, HKT1, and NHX1, thus protecting the stability of Na(+) and K(+). …”
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“…The risk factors were AC084117.1, SOS1-IT1, AC019080.5, FIRRE and MCCC1-AS, and the protective factors were AC034236.2, POC1B-AS1, AC137630.1, AC083799.1 and AL133243.2. …”
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“…In addition, Put significantly up-regulated the AsSOS1, NHX6, SKOR, HKT1, and HKT8 expression levels which played critical roles in Na(+) rejection and K(+) retention resulting in higher K(+)/Na(+) ratio during seed germination under salt stress. …”
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“…In addition, PePLDδ-overexpressed plants increased the transcription of genes encoding the plasma membrane Na(+)/H(+) antiporter (AtSOS1) and H(+)-ATPase (AtAHA2), which enabled transgenic plants to proceed with Na(+) extrusion and reduce K(+) loss under salinity. …”
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“…PEs have been reported to enhance salt tolerance in plants primarily through modulation of signaling signatures and pathways (e.g., Na(+), ANNA4, GIPC, SOS3, and SCaBP8 Ca(2+) sensors, etc.), and regulation of redox machinery [e.g., superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), non-specific peroxidase (POX), glutathione peroxidase (GPX), peroxiredoxin (Prx), ascorbic acid (AsA), glutathione (GSH), α-tocopherol, etc.]. …”
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“…This cohort study included 2106 adult (≥18 years) surgical patients who consented to participate in the SATISFY-SOS registry (February 1, 2015 to September 30, 2017). …”
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“…Results: Through the LASSO regression analysis, we constructed a novel KIRC prognosis–related risk model using 12 genes: SHC1, GAB1, SOS2, SRC, AKT3, EREG, EIF4EBP1, ERBB3, MAPK3, transforming growth factor-alpha, CDKN1A, and PIK3CD. …”
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“…However, from kinase prediction, kinase-substrate interaction analysis, and KEGG functional enrichment analysis done with phosphoproteome data, we observed high phosphorylation of fatty acid biosynthesis, β-oxidation, and potential secretory processes, together with low phosphorylation of the Egfr-Sos1-Araf/Braf-Map2k1-Mapk1 pathway and Ctnnb1 during aging. …”
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“…Principal component analysis (PCA) analysis showed that exogenous Tre could change the distribution of elements in different organs and affect the expressions of SlSOS1, SlNHX, SlHKT1.1, SlVHA, and SlHA-A at the transcriptional level under salt stress, thereby maintaining ion homeostasis. …”
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“…We investigated the anti-tumor efficacy of two KRAS inhibitors BI-3406 (KRAS::SOS1 inhibitor) and sotorasib (KRAS G12C inhibitor) alone or in combination with MEK1/2 inhibitor trametinib and/or PI3K inhibitor buparlisib in seven PDAC cell lines. …”
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“…Conversely, there was a significant down-regulation in the expression ZmSOS1 and ZmNHX1 by 48.2 and 27.8%, respectively, compared to the untreated plants.…”
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“…During the DEG analysis, we identified eight up-regulated genes (LOC695323, TMEM107, LOC695427, HIST1H2AD, LOC705469, PMAIP1, HIST1H2BJ, and HIST1H3D) and 16 down-regulated genes (HOXA9, BAMBI, LMO4, PAX6, AJUBA, CREBRF, CD24, JADE1, SLC7A11, EID2, SOX4, B4GALT5, PPARGC1A, BUB3, SOS2, and CDK19). We also developed PPI networks and performed co-expression analyses using the top-ranked genes. …”
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“…The results of the experiments in a comparative study under the same conditions show that the CMOA is superior to the newly-developed metaheuristic algorithms including AIDO, ITGO, RFOA, SCA, CSA, CS, SOS, GWO, WOA, MFO, PSO, Jaya, CMA-ES, GSA, RW-GWO, mTLBO, MG-SCA, TOGPEAe, m-SCA, EEO and OB-L-EO, indicating the effectiveness and robustness of the CMOA algorithm as a powerful algorithm. …”
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